Patents Assigned to Ciphergen Biosystems, Inc.
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Patent number: 8198019Abstract: The present invention is a method for early detection of cancer including the steps of identifying tissue from asymptomatic individuals, gathering a substantially homogenous cell population from the tissue by laser capture microdissection (LCM), analyzing the cell population with mass spectrometry and identifying predetermined peaks in the mass spectrometry associated with an overexpression of proteins in premalignant and malignant cells.Type: GrantFiled: April 3, 2003Date of Patent: June 12, 2012Assignees: University of South Florida, Ciphergen Biosystems, Inc.Inventors: Tatyana A. Zhukov, Melvyn S. Tockman, Roy A. Johanson
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Publication number: 20100197561Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.Type: ApplicationFiled: June 23, 2006Publication date: August 5, 2010Applicant: Ciphergen Biosystems, Inc.Inventors: Eric Thomas Fung, Enrique Dalmasso, Valdimir Podust, Zheng Wang
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Publication number: 20090181414Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.Type: ApplicationFiled: September 25, 2006Publication date: July 16, 2009Applicant: Ciphergen Biosystems, Inc.Inventors: T. William Hutchens, Tai-Tung Yip
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Publication number: 20090042229Abstract: The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.Type: ApplicationFiled: April 22, 2005Publication date: February 12, 2009Applicants: CIPHERGEN BIOSYSTEMS, INC., CHILDRENS MEDICAL CENTER CORPORATIONInventors: Judah M. Folkman, Giannoula Klement, Tai-Tung Yip, William E. Rich, Vladimir N. Podust
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Publication number: 20080311673Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying breast cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as breast cancer or non-breast cancer. The biomarkers can be detected by SELDI mass spectrometry.Type: ApplicationFiled: September 16, 2005Publication date: December 18, 2008Applicants: The Johns Hopkins University, Ciphergen Biosystems, Inc.Inventors: Jinong Li, Carolyn N. White, Zhen Zhang, Daniel W. Chan, Eric T. Fung, Xiao-Ying Meng
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Publication number: 20080298740Abstract: The invention provides an integrated optical waveguide sensor module (200) with reduced signal modulation and increased sensitivity. An optical waveguide sensor module (200) comprises an optically transparent substrate (210) having a first and a second interface and an optical waveguide film (220) disposed on the substrate (210) with the first interface (225) therebetween, wherein the film (220) comprises at least one grating pad (235) that is optically coupled therewith. The substrate (210) and the optical waveguide film (220) are configured to reduce parasitic interference within the substrate.Type: ApplicationFiled: May 18, 2005Publication date: December 4, 2008Applicant: Ciphergen Biosystems, Inc.Inventors: Louis Hlousek, Rino E. Kunz, Guy Voirin, Kaspar Cottier
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Publication number: 20080128613Abstract: The invention provides apparatus and methods for performing time-of-flight (TOF) mass spectrometry. A TOF mass spectrometer of the present invention comprises one or more ion focusing electric sectors. At least one of the electric sectors is associated with an ion optical element. The ion optical elements comprise at least one adjustable electrode, such that the adjustable electrode is able to modify the potential experienced by an ion entering or exiting the electric sector with which it is associated.Type: ApplicationFiled: June 15, 2007Publication date: June 5, 2008Applicants: Bio-Rad Laboratories, Inc., Ciphergen Biosystems, Inc.Inventor: Sidney E. Buttrill
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Publication number: 20080081342Abstract: This invention provides biomarkers whose concentrations in blood plasma are associated with the presence or absence of PAD in the patient from whom the plasma sample is taken. The invention also provides biomarkers for distinguishing between PAD patients who are long claudicators and PAD patients who are not. In addition, the invention provides methods for identifying additional biomarkers, methods for detecting the biomarkers in patients, and methods for identifying agents, including pharmaceutical agents, which interact with the biomarkers and are useful for preventing or treating PAD in patients.Type: ApplicationFiled: May 26, 2005Publication date: April 3, 2008Applicant: Ciphergen Biosystems, IncInventor: Eric T Fung
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Patent number: 7247846Abstract: The invention provides apparatus and methods for performing time-of-flight (TOF) mass spectrometry. A TOF mass spectrometer of the present invention comprises one or more ion focusing electric sectors. At least one of the electric sectors is associated with an ion optical element. The ion optical elements comprise at least one adjustable electrode, such that the adjustable electrode is able to modify the potential experienced by an ion entering or exiting the electric sector with which it is associated.Type: GrantFiled: June 8, 2005Date of Patent: July 24, 2007Assignee: Ciphergen Biosystems, Inc.Inventor: Sidney E Buttrill, Jr.
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Publication number: 20070065953Abstract: The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes methods and kits for dynamically reducing the variance between analyte taken from complex mixtures.Type: ApplicationFiled: July 28, 2006Publication date: March 22, 2007Applicant: Ciphergen Biosystems, Inc.Inventors: Egisto Boschetti, David Hammond
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Publication number: 20070054329Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status as well as endometrical cancer status in a patient. In particular, it has been found that hepcidin is a biomarker for both ovarian cancer and endometrial cancer and that a panel of biomarkers, including hepcidin, transthyretin and optionally other markers are useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.Type: ApplicationFiled: March 10, 2006Publication date: March 8, 2007Applicants: Ciphergen Biosystems, Inc., The Johns Hopkins University, Board of Regents, The University of Texas SystemInventors: Eric Fung, Robert Bast, Daniel Chan, Jin Song, Valdimir Podust, Zhen Zhang
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Patent number: 7183544Abstract: In relation to a chromatographic chip, for protein separation, a polymer surface is provided that has a first polymer layer, attached to a support surface, which can be anionic or cationic. To the first layer is attached a second polymer layer, characterized by an opposite charge.Type: GrantFiled: December 17, 2004Date of Patent: February 27, 2007Assignee: Ciphergen Biosystems Inc.Inventors: Egisto Boschetti, Luc Bourgeois
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Publication number: 20070042414Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.Type: ApplicationFiled: August 23, 2006Publication date: February 22, 2007Applicant: Ciphergen Biosystems, Inc.Inventors: T. Hutchens, Tai-Tung Yip
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Publication number: 20070015221Abstract: The present invention provides a neurosecretory protein VGF peptide useful in qualifying Alzheimer's disease status in a patient. In particular, this peptide and modified forms thereof may be used to classify a subject sample as Alzheimer's disease or non-Alzheimer's disease. The peptide biomarker can be detected by SELDI mass spectrometry.Type: ApplicationFiled: June 13, 2006Publication date: January 18, 2007Applicant: Ciphergen Biosystems, Inc.Inventors: Huw Davies, Kaj Blennow, James McGuire, Vladimir Podust, Anja Simonsen
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Patent number: 7160734Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.Type: GrantFiled: May 17, 2002Date of Patent: January 9, 2007Assignee: Ciphergen Biosystems, Inc.Inventors: T. William Hutchens, Tai-Tung Yip
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Patent number: 7129483Abstract: Laser desorption/ionization time-of-flight mass spectrometer (“LDI-TOF-MS”) devices, and methods, that accurately measure the mass of analytes contained in a sample and which also measure the quantities of analytes present in a sample in a consistent manner from instrument-to-instrument and over time on a single instrument. In particular, the invention provides LDI-TOF-MS devices and methods in which: 1) the energy of the laser pulse and the area of the sample illuminated (fluence) is consistent and controlled so as to produce consistent conditions for analyte desorption and ionization; 2) the mass analyzer behaves in a reproducible manner; and 3) the detection system produces a signal that consistently represents the arrival of ions of different masses.Type: GrantFiled: June 17, 2005Date of Patent: October 31, 2006Assignee: Ciphergen Biosystems, Inc.Inventors: Michael G. Youngquist, Craig A. Keller
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Publication number: 20060240495Abstract: Assessing fetal health and maturity, and the integrity and health of the amnion, is effected via protein profiling of vaginal fluid, thereby to identify various abnormal conditions during pregnancy. This approach also provides a means for gauging the duration and/or magnitude of intraamniotic/fetal inflammation that occurs during pregnancy.Type: ApplicationFiled: November 13, 2003Publication date: October 26, 2006Applicant: Ciphergen Biosystems, Inc.Inventors: Irina Buhimschi, Robert Christner, Catalin Buhimschi, Carl Weiner
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Publication number: 20060216751Abstract: The present invention provides methods and kits for purifying a target protein group. The method comprises the steps of contacting a sample comprising at least 95% of the target protein group and at most 5% of contaminating proteins with a library of binding moieties having different binding moieties, binding the contaminating proteins and a minority of the target protein group to the library of binding moieties, separating the unbound target protein group from the proteins bound to the library of binding moieties and collecting the unbound target protein. The collected target protein is more pure than the target protein group in the sample.Type: ApplicationFiled: March 22, 2006Publication date: September 28, 2006Applicant: Ciphergen Biosystems, Inc.Inventors: Egisto Boschetti, Lee Lomas
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Patent number: 7112453Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.Type: GrantFiled: August 5, 2002Date of Patent: September 26, 2006Assignee: Ciphergen Biosystems, Inc.Inventors: T. William Hutchens, Tai-Tung Yip
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Patent number: 7105339Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.Type: GrantFiled: July 23, 2003Date of Patent: September 12, 2006Assignee: Ciphergen Biosystems, Inc.Inventors: T. William Hutchens, Tai-Tung Yip