Abstract: During the process of coagulation, prothrombin is activated to ?-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for modulation of the activation of prothrombin. In certain embodiments, a recombinant prothrombin with at least one point mutation or deletion is provided.

Abstract: A tumor resection process includes the administration of an iridium-containing nucleoside, medical imaging, and tumor and tumor margin removal.

Abstract: A method of inducing HEXIM1 expression in cells of a subject includes administering to the cells a compound having the formula, and pharmaceutically acceptable salts thereof.

Abstract: An antiviral composition contains a sialidase inhibitor. Methods for treating a viral infection include administering the composition to a patient. The sialidase inhibitor may be of general formula (l) wherein R1 is selected from the group consisting of OH, O-acetyl, N3, OCOCH2X1 and NHCOCHX1; X1 is selected from the group consisting of H, a C1-C5 alkyl group, acetyl, propionyl, butyryl, valoryl, hexanoyl, pentanoyl, and 2-methylpropanyl; R2 is H or COCH2X2; X2 is selected from the group consisting of H, a C1-C5 alkyl group, acetyl, propionyl, butyryl, valoryl, hexanoyl, pentanoyl, and 2-methylpropanyl; R3 is selected from the group consisting of H, OH, COCH2X3 and OCOCH2X3; X3 is selected from the group consisting of H, a C1-C5 alkyl group, acetyl, propionyl, butyryl, valoryl, hexanoyl, pentanoyl, and 2-methylpropanoal; R4 is selected from the group consisting of H, OH, a C1-C6 alkyl group, and CH2X4; and X4 is H or a C1-C6 alkyl group.

Abstract: A perfusion plate that can be combined with pillar plates containing cell layers is disclosed. The perfusion plate can have an inflow reservoir and an outflow reservoir connected by at least one channel, which fluidly connects the perfusion wells to the reservoirs for the flow of a fluid such as growth media. A perfusion plate can be part of an assembly containing a pillar plate, a lid, and a transparent bottom for visualizing cell growth in the perfusion wells. The perfusion-pillar plate assembly can facilitate perfusion-based tissue culture and tissue communication for high throughput, high-content, drug screening.

Abstract: Systems and methods to perform privacy-aware computer-vision-based human activity monitoring with real-time haptic feedback. The system and method described in this disclosure employing a registration process for consenting human subjects before their activities are monitored. The registration process involves the corroboration of human motion captured in different modalities, i.e., computer-vision-based via the programmable computer-vision-based motion sensor and accelerometer-based via the wearable device. The tracked human activities are assessed in real-time and upon detection of activities that violated predefined rules, haptic feedback is delivered in real-time to the tracked human subject via the wearable device worn by the caregiver.

Abstract: Therapeutic compositions and methods for treating a patient having sickle cell anemia or beta-thalassmia by administering, in therapeutically effective amounts, a composition of an effective amount of an inhibitor of Pumilio-1.

Abstract: A rotation monitoring system may be attached to a limb and can identify ranges of motion that are associated with injuries or poor performance. In some embodiments, the device is designed to monitor flexion and orientation of joints and limbs, developed specifically around identifying stress concentrating behavior on the ACL. Tests performed show that the designed device can read flexion and orientation of the knee, is durable enough to be used in real-world conditions, and does not impede on the subject's movements.

Abstract: A method for producing an aligned boron nitride nanotube film includes drying a dispersion containing boron nitride nanotubes, a biopolymer, and a solvent.

Abstract: Compositions contain boron nitride nanomaterials at least partially coated with biomolecules.

Abstract: The present disclosure pertains to a system that may be configured to operate a power grid, including generation participants, consumers, and a controller that administers a market for the power generation participants and the consumers on the power grid. The operation of the power grid may include: performing power grid coordination calculations based upon, at least in part, constraints that pertain to the flow and/or congestion of power on the grid; and managing the coordination calculations by reducing a number of constraints used in the coordination calculations, the managing including a first step of coarse screening of the constraints, a second step of deterministic fine screening of the constraints, and a third step of statistical fine screening of the constraints. This second step may cause identification of constraints that are redundant and/or dominated by other constraints.

Abstract: An article (e.g., an interbody device) contains a polymer (e.g., polyetheretherketone (PEEK)) and transition metal-doped amorphous magnesium phosphate.

Abstract: A micropillar and microwell chip and methods of studying cellular environments using micropillar and microwell chips is disclosed. The micropillar chip may include at least one micropillar with a pillar-microwell. The microwell chip may include at least one microwell with an upper and a lower microwell. A perfusion channel chip that may be integrated with a micropillar chip is also disclosed. The perfusion channel chip may include a channel, a pillar-insertion hole, a membrane cassette, and a reservoir well.

Abstract: Systems and methods to perform privacy-aware computer-vision-based human activity monitoring with automatic registration are disclosed. To register for tracking, consenting human subjects wear beacons that emit a beacon signal. During a predefined timing window, beacon signals are detected and compared to a predefined signal-strength threshold and compared to the signal strength of other different beacon signals detected during the same timing window. At the end of the timing window, the strongest beacon signal above the threshold is selected for registration. The tracked human activities are assessed in real-time and upon detection of activities that violated predefined rules, feedback is delivered in real-time to the tracked human subject.

Abstract: Disclosed are methods and compositions for identifying and treating certain conditions and diseases. In certain instances, the general inventive concepts provide methods for determining rhTRAIL sensitivity of a sample and/or methods and compositions for inducing apoptosis to treat conditions and diseases with rhTRAIL.

Abstract: An authentication method and system includes a computing device, such as a smart phone, which includes a display for presenting a graphical and interactive game board that is used for entering a user's passcode. During the authentication process, the user selects a game board (e.g. chess, checkers, poker, backgammon, etc.) and associated game pieces for presentation on the display. The user then moves one or more game pieces to locations on the game board. Together, the selected game board, selected game pieces, and the movements and/or locations which the game pieces are moved on the game board form an entered passcode. This generated passcode is then compared with a stored passcode to authenticate the user before granting access to the computing device.

Abstract: A multiplexed method of monitoring immune-cell responses to different ligands using a micropillar/microwell plate platform is disclosed. The method may include dispensing immune cells onto at least one micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains at least one test compound. The method may also include immobilizing antibodies onto at least one micropillar on a micropillar chip and inserting the at least one micropillar into at least one microwell on a microwell chip, in which the at least one microwell contains a test compound. The method may also include treating the micropillar chip with at least one reactive polymer.

Abstract: An exoskeleton system is passively powered and pneumatically operated. The system may be a lower-limb system for walking gait restoration. The system may include a first linear actuator located in front of an upper leg section and a second linear actuator located behind a lower leg section.

Abstract: The present exemplary embodiments relate to a privacy preserving approach to peak load management. It finds example application in conjunction with, for example, power systems, such as smart homes, smart buildings, microgrids, distribution systems and bulk systems, and energy management systems.

Abstract: Compositions contain boron nitride nanomaterials at least partially coated with biomolecules.