Patents Assigned to Clinical Micro Sensors, Inc.
  • Publication number: 20080248592
    Abstract: The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte to be determined.
    Type: Application
    Filed: October 31, 2007
    Publication date: October 9, 2008
    Applicant: Clinical Micro Sensors, Inc.
    Inventors: Cynthia C. Bamdad, Robert C. Mucic
  • Publication number: 20080237061
    Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
    Type: Application
    Filed: October 30, 2007
    Publication date: October 2, 2008
    Applicant: Clinical Micro Sensors, Inc.
    Inventors: Stephen D. O'Connor, Jon Faiz Kayyem, Thomas J. Meade
  • Publication number: 20080242553
    Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.
    Type: Application
    Filed: October 31, 2007
    Publication date: October 2, 2008
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Jon Faiz Kayyem
  • Publication number: 20080202927
    Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.
    Type: Application
    Filed: January 25, 2007
    Publication date: August 28, 2008
    Applicant: Clinical Micro Sensors, Inc.
    Inventors: Jon F. Kayyem, Stephen D. O'Connor
  • Publication number: 20080179196
    Abstract: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 31, 2008
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Thomas J. Meade
  • Publication number: 20080173553
    Abstract: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 24, 2008
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Thomas J. Meade
  • Publication number: 20080173554
    Abstract: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 24, 2008
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Thomas J. Meade
  • Publication number: 20080171340
    Abstract: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 17, 2008
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Thomas J. Meade
  • Patent number: 7393645
    Abstract: The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes.
    Type: Grant
    Filed: August 19, 2005
    Date of Patent: July 1, 2008
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor
  • Publication number: 20080135420
    Abstract: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Application
    Filed: August 2, 2007
    Publication date: June 12, 2008
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Thomas J. MEADE
  • Patent number: 7384749
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: June 10, 2008
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon F. Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
  • Patent number: 7381525
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: June 3, 2008
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor
  • Patent number: 7381533
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: June 3, 2008
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon F. Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
  • Patent number: 7312087
    Abstract: The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips include a substrate, the substrates including an array of detection electrodes, each electrode including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contracts, detecting current as an indication of the presence of the labels on the first biochip, and detecting current as an indication of the presence of the labels on the first second biochip. The devices and method may be used with multiple cartridges comprising biochips comprising arrays, such as nucleic acid arrays, and allow for high throughput analysis of samples.
    Type: Grant
    Filed: January 11, 2001
    Date of Patent: December 25, 2007
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Hau H. Duong, Gary Blackburn, Jon F. Kayyem, Stephen D. O'Connor, Gary T. Olsen, Robert Pietri, Robert H. Terbrueggen
  • Patent number: 7267939
    Abstract: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: September 11, 2007
    Assignee: Clinical Micro Sensors, Inc.
    Inventor: Thomas J. Meade
  • Publication number: 20070098600
    Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.
    Type: Application
    Filed: September 18, 2006
    Publication date: May 3, 2007
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Jon Kayyem
  • Patent number: 7172897
    Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: February 6, 2007
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Gary Blackburn, Hau H. Duong, Piotr Grodzinski, Jon Faiz Kayyem, Stephen D. O'Connor, Robert Pietri, Robert Henry Terbrueggen, Frederic Zenhausern, Gary T. Olsen
  • Patent number: 7160678
    Abstract: The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: January 9, 2007
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor
  • Patent number: 7125668
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: October 24, 2006
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu
  • Patent number: 7087148
    Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: August 8, 2006
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Gary Blackburn, Jost G. Vielmetter, Jon Faiz Kayyem