Patents Assigned to Clue
  • Publication number: 20220135560
    Abstract: A pyrazolo[1,5-a]pyridine derivative, and a preparation method and medical use thereof are provided. The pyrazolo[1,5-a]pyridine derivative shown in general formula (I), a preparation method of the derivative, a pharmaceutically acceptable salt of the derivative, and use of the derivative or salt as a therapeutic agent, especially as a rearranged during transfection (RET) inhibitor, are provided.
    Type: Application
    Filed: March 2, 2020
    Publication date: May 5, 2022
    Applicant: CLUES THERAPEUTICS (SHANGHAI) LTD
    Inventors: Suxin ZHENG, Zhongli WANG, Jianping ZHANG, Jun LIU, Quanlin AN, Wenwen ZHAO
  • Patent number: 8608821
    Abstract: The invention provides a method for the combined production of (i) a fertilizer selected from the group consisting of ammonium nitrate, ammonium phosphates or a combination thereof, (ii) a concentrated stream of CO2 through an indirect neutralization of ammonia with an acid selected from the group consisting of nitric acid, phosphoric acid, a salt thereof and a combination thereof; said method comprising: (I) reacting a carbonate product with a reagent selected from the group consisting of nitric acid, phosphoric acid, a salt thereof, and a mixture thereof to form CO2, and a fertilizer containing an ammonia component; and (II) separating at least a portion of said carbon dioxide from said fertilizer in a condensed and relatively concentrated stream.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: December 17, 2013
    Assignee: Clue AS
    Inventor: Riki Canari
  • Patent number: 8524180
    Abstract: The invention provides a process for minimizing the emission of particulate matter and precursors thereof from a flue gas stream of an engine comprising particulate matter and precursors thereof and at least one gaseous component. The process includes the steps of obtaining a flue gas stream of an engine comprising particulate matter and precursors thereof; increasing the moisture content of the stream by contacting it with a first aqueous medium in an amount and at a temperature at which at least 50% of the water content of the first aqueous medium is evaporated; whereby a moisture laden gas stream, optionally containing suspension droplets, is formed; cooling the moisture laden gas stream whereby suspension droplets are formed; and applying a centrifugal force to the moisture laden gas stream and to the suspension droplets to effect the swirling thereof, whereby a treated gaseous stream and an aqueous stream are formed.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: September 3, 2013
    Assignees: Vortex Ecological Technologies Ltd., Clue AS, Clean Marine AS
    Inventors: Riki Canari, Aharon Eyal, Nils Christian Hoy-Petersen, Matitiahu Fichman, Carl Christian Hauge, Carmi Raz
  • Patent number: 8345048
    Abstract: A displaying chart image in a bitmap format is generated from ledger sheet data, while identifying layout information capable of identifying a plurality of line drawings on the chart image respectively is generated for a mouse decision. Then, identifying information corresponding to a dot designated through a mouse cursor over the displaying chart image is acquired from the identifying layout information and a dot string indicated by the identifying information is specified as the line drawing. Consequently, it is possible to increase a display speed more greatly as compared with the case in which the line drawings are subjected to vector rendering and are thus displayed respectively, and to identify the line drawings in the chart image formed into a bitmap based on the identifying layout information, respectively.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: January 1, 2013
    Assignees: 1st Holdings, Inc., Four-Clue Inc.
    Inventors: Ko Shimazawa, Jun Tanaka
  • Patent number: 8318803
    Abstract: The present invention relates to an EC SOD and the use thereof. More particularly, the present invention relates to an EC SOD and the use thereof for preventing or treating skin diseases, particularly dermatitis or psoriasis.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: November 27, 2012
    Assignees: Bio Clue & Solution Co., Ltd.
    Inventors: Tae-Yoon Kim, Bo-Yeun Choung
  • Publication number: 20120213433
    Abstract: A portion within an image in which a plurality of objects (21 and 22) overlap is partitioned into a plurality of small regions (31a and 32a), each of the units of identification information for the plurality of objects (21 and 22) is assigned to a dot corresponding to the plurality of small regions (31a and 32a), and thereby, identification-use layout information is generated, whereby even if a plurality of objects overlap upon a layout of a display image, upon the layout of the identification-use layout information that has been generated for identifying the plurality of objects, the identification information corresponding to each object does not overlap. As a result, it is possible to identify each object by the identification information acquired from the position of the cursor.
    Type: Application
    Filed: December 20, 2010
    Publication date: August 23, 2012
    Applicants: Four-Clue Inc., 1st Holdings, Inc.
    Inventors: Ko Shimazawa, Jun Tanaka
  • Patent number: 8152891
    Abstract: The invention provides a method for the combined production of (I) a sulfur oxide containing product and (II) a fertilizer selected from a group consisting of ammonium nitrate, ammonium phosphates and a combination thereof, through an indirect neutralization of ammonia with an acid selected from the group consisting of nitric acid, phosphoric acid and a combination thereof, the method comprising: a. contacting a precipitate containing calcium sulfite with a solution of nitric acid and a solution of ammonia in two separate steps, to form the fertilizer, the sulfur oxide containing product and a precipitate containing calcium hydroxide; and b. separating at least portion of the fertilizer, the sulfur oxide and the calcium hydroxide into three separated streams.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: April 10, 2012
    Assignee: Clue AS
    Inventor: Riki Canari
  • Publication number: 20110289448
    Abstract: When an icon associated with a folder one level lower is displayed within a window, files and folders included in the folder one level lower can be shown to a user in an easy-to-understand manner at a glance by previewing icons displayed in relation to files and folders two levels lower on the icon associated with the folder one level lower according to layout information belonging to the folder one level lower, and the files and folders two levels lower included in the folder one level lower can be previously confirmed by the preview even if the user actually performs no operation for specifying the folder one level lower.
    Type: Application
    Filed: February 4, 2010
    Publication date: November 24, 2011
    Applicants: Four-Clue Inc., 1st Holdings, Inc.
    Inventor: Jun Tanaka
  • Publication number: 20110273453
    Abstract: A displaying chart image in a bitmap format is generated from ledger sheet data, while identifying layout information capable of identifying a plurality of line drawings on the chart image respectively is generated for a mouse decision. Then, identifying information corresponding to a dot designated through a mouse cursor over the displaying chart image is acquired from the identifying layout information and a dot string indicated by the identifying information is specified as the line drawing. Consequently, it is possible to increase a display speed more greatly as compared with the case in which the line drawings are subjected to vector rendering and are thus displayed respectively, and to identify the line drawings in the chart image formed into a bitmap based on the identifying layout information, respectively.
    Type: Application
    Filed: November 11, 2010
    Publication date: November 10, 2011
    Applicants: Four-Clue Inc., 1st Holdings, Inc.
    Inventors: Ko Shimazawa, Jun Tanaka
  • Patent number: 7935678
    Abstract: Disclosed is the therapeutic use of CpG oligodeoxynucleotides for skin diseases. The CpG oligodeoxynucleotides (CpG ODNs) of the present invention show excellent immunoactive effects against skin diseases in both cases of CpG ODNs with a phosphorothioate backbone and CpG ODNs with a phosphodiester backbone.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: May 3, 2011
    Assignees: Bio Clue & Solutions Co, Ltd.
    Inventors: Tae-Yoon Kim, Doo-Sik Kim, Hyung-Joo Kwon, Yang-Soon Kim
  • Publication number: 20100266568
    Abstract: The present invention relates to an EC SOD and the use thereof. More particularly, the present invention relates to an EC SOD and the use thereof for preventing or treating skin diseases, particularly dermatitis or psoriasis.
    Type: Application
    Filed: April 22, 2010
    Publication date: October 21, 2010
    Applicants: BIO CLUE & SOLUTION CO., LTD.
    Inventors: Tae-Yoon Kim, Bo-Yeun Choung
  • Patent number: 7780932
    Abstract: A process for desulfurizing an SO2-comprising gaseous stream comprising the steps of: a. providing an aqueous feed comprising an anion selected from a group consisting of carbonate, bicarbonate, hydroxide, sulfite, and hydrogen sulfite; b. providing an SO2-comprising gaseous feed; and c. contacting the aqueous feed and the gaseous feed to generate a desulfurized gaseous product comprising less than 40% of the feed SO2 content, and an aqueous product; wherein the contacting is carried out in a cyclone unit comprising a housing defined by a cylindrical peripheral wall and provided with at least one inlet opening for receiving fluids thereinto and with at least one swirling means, and wherein the cyclone unit is characterized in that the velocity of the gaseous stream inside the cyclone unit is between 20 m/sec and 120 m/sec.
    Type: Grant
    Filed: September 4, 2007
    Date of Patent: August 24, 2010
    Assignees: Clue AS, Eyal Research Consultants Ltd.
    Inventors: Riki Canari, Aharon Eyal
  • Patent number: 7740839
    Abstract: The present invention relates to an EC SOD, a cell-transducing EC SOLD, and the use thereof. More particularly, the present invention relates to an EC SOD, an EC SOD fusion protein enhanced Cell-transduction ability, and the use thereof for preventing or treating skin diseases.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: June 22, 2010
    Assignees: Bio Clue & Solution Co., Ltd.
    Inventors: Tae-Yoon Kim, Bo-Yeun Choung
  • Publication number: 20100132422
    Abstract: The invention provides a method for the combined production of (i) a fertilizer selected from the group consisting of ammonium nitrate, ammonium phosphates or a combination thereof, (ii) a concentrated stream of CO2 through an indirect neutralization of ammonia with an acid selected from the group consisting of nitric acid, phosphoric acid, a salt thereof and a combination thereof; said method comprising: (I) reacting a carbonate product with a reagent selected from the group consisting of nitric acid, phosphoric acid, a salt thereof, and a mixture thereof to form CO2, and a fertilizer containing an ammonia component; and (II) separating at least a portion of said carbon dioxide from said fertilizer in a condensed and relatively concentrated stream.
    Type: Application
    Filed: July 31, 2006
    Publication date: June 3, 2010
    Applicant: CLUE AS
    Inventor: Riki Canari
  • Publication number: 20090260519
    Abstract: The present invention provides a process for the absorption of sulfur dioxide from flue gases comprising the steps of: a) providing input seawater or brackish water; b) treating at least a portion of the seawater or brackish water to form a more concentrated solution of ions; and c) contacting the flue gas with an aqueous stream containing the concentrated solution to form flue gas with a reduced content of sulfur dioxide and a wash solution. wherein the treatment in stage (b) is a process selected from the group consisting of vacuum distillation, distillation, reverse osmosis, or any combination thereof.
    Type: Application
    Filed: September 4, 2007
    Publication date: October 22, 2009
    Applicant: CLUE AS
    Inventor: Riki Canari
  • Publication number: 20090257932
    Abstract: A process for desulfurizing an SO2-comprising gaseous stream comprising the steps of: a. providing an aqueous feed comprising an anion selected from a group consisting of carbonate, bicarbonate, hydroxide, sulfite, and hydrogen sulfite; b. providing an SO2-comprising gaseous feed; and c. contacting the aqueous feed and the gaseous feed to generate a desulfurized gaseous product comprising less than 40% of the feed SO2 content, and an aqueous product; wherein the contacting is carried out in a cyclone unit comprising a housing defined by a cylindrical peripheral wall and provided with at least one inlet opening for receiving fluids thereinto and with at least one swirling means, and wherein the cyclone unit is characterized in that the velocity of the gaseous stream inside the cyclone unit is between 20 m/sec and 120 m/sec.
    Type: Application
    Filed: September 4, 2007
    Publication date: October 15, 2009
    Applicants: CLUE AS, EYAL RESEARCH CONSULTANTS LTD.
    Inventors: Riki Canari, Aharon Eyal
  • Publication number: 20080069808
    Abstract: The present invention relates to an EC SOD, a cell-transducing EC SOLD, and the use thereof. More particularly, the present invention relates to an EC SOD, an EC SOD fusion protein enhanced Cell-transduction ability, and the use thereof for preventing or treating skin diseases.
    Type: Application
    Filed: October 29, 2004
    Publication date: March 20, 2008
    Applicants: BIO CLUE & SOLUTION CO., LTD
    Inventors: Tae-Yoon Kim, Bo-Yeun Choung
  • Patent number: 6562304
    Abstract: The invention relates to a novel and most efficient scrubber for the treatment of flue gases from power generation plants or from chemical plants, in order to absorb objectionable impurities, such as SO2, SO3, HCl, nitrous oxides, into a water-based solution, in which solids are not substantially precipitated. The novel scrubber comprises: a horizontal chamber, with a basis rectangular vertical cross section, divided along the horizontal axis into a number of compartments by vertically-draining demisters covering the whole vertical cross section; a shallow liquid-collecting sump in each compartment, which can be sloped in any convenient direction; a pump which distributes the liquid from each such sump, at a controlled flow-rate to a series of spray nozzles in the same compartment, generating 3-5 vertical “falling curtains” perpendicularly to the gas flow and covering the whole vertical cross section, while the liquid drops fall back into the sump.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: May 13, 2003
    Assignee: Clue AS
    Inventor: Joseph Mizrahi
  • Patent number: 6344066
    Abstract: A method for the combined production of (I) a fertilizer selected from a group consisting of ammonium nitrate, ammonium phosphates or a combination thereof through an indirect neutralization of ammonia with an acid selected form a group consisting of nitric acid, phosphoric acid and a combination thereof and of (II) a sulfur compound selected from a group consisting of elemental sulfur, SO2, sulfuric acid and sulfate salts, said method comprising (a) contacting a sulfur oxide containing gas with ammonia and an aqueous liquor, whereby a sulfur oxide containing product is formed and the resulting gas has a reduced SO2 content; (b) reacting a sulfur oxide containing product resulting from step (a) with a reagent selected from a group consisting of nitric acid, phosphoric acid, a mixture thereof and salts formed by the reaction of said acids to form said fertilizer and a sulfur compund, and (c) separating at least a portion said sulfur compound from said fertilizer.
    Type: Grant
    Filed: May 24, 2000
    Date of Patent: February 5, 2002
    Assignee: Clue
    Inventor: Aharon Meir Eyal
  • Patent number: D848555
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: May 14, 2019
    Assignee: Hermes Clues Industries Co. Ltd.
    Inventor: Hui-Chin Chang