Abstract: A centrifuge apparatus for processing blood comprising a bottom spring-loaded support plate; a top support plate; an axial inlet/outlet for blood to be processed and processed components of the blood, the axial inlet/outlet being attached to the top support plate by a rotating seal assembly; a variable volume separation chamber mounted between the bottom support plate and the top support plate, the variable volume separation chamber being fluidly connected to the axial inlet/outlet; a pump fluidly connected to the axial inlet/outlet; and a rotary drive unit attached to the bottom support plate. The top support plate is fixed vertically and the bottom spring-loaded support plate is mounted on springs that maintain pressure on the variable volume separation chamber and allow the bottom support plate to move vertically.

Abstract: Accurate measurement of hematocrit during blood recovery or plasma sequestration processes by means of algorithms to account for the presence of air or other non-blood substances in salvaged or separated blood is described. A method of automatic start-up of the hematocrit measurement circuit and a method of determining the minimum volume of blood required to obtain an accurate measurement of the hematocrit also is described.

Abstract: An integrated package suited to the packaging of medical devices and surgical equipment including devices and equipment used in heart by-pass surgery has a container and a snap-fit lid. The container and the lid have topographies suitable to conform to the medical components in the container and hold them securely. The lid has first and second grooves which engage a projection on the container and permit the lid to be used in a shipping orientation and a disposal orientation.

Abstract: Accurate measurement of hematocrit during blood recovery or plasma sequestration processes by means of algorithms to account for the presence of air or other non-blood substances in salvaged or separated blood is described. A method of automatic start-up of the hematocrit measurement circuit and a method of determining the minimum volume of blood required to obtain an accurate measurement of the hematocrit also is described.

Abstract: An integrated package suited to the packaging of medical devices and surgical equipment including devices and equipment used in heart by-pass surgery has a container and a snap-fit lid. The container and the lid have topographies suitable to conform to the medical components in the container and hold them securely. The lid has first and second grooves which engage a projection on the container and permit the lid to be used in a shipping orientation and a disposal orientation.

Abstract: Accurate measurement of hematocrit during blood recovery or plasma sequestration processes by means of algorithms to account for the presence of air or other non-blood substances in salvaged or separated blood is described. A method of automatic start-up of the hematocrit measurement circuit and a method of determining the minimum volume of blood required to obtain an accurate measurement of the hematocrit also is described.

Abstract: An exchanger and method for manufacturing the same are disclosed. In one embodiment, the exchanger crimps a hollow fiber bundle along a length of a cylindrical case in at least two radial positions. At least one crimp is between an inlet port and an outlet port of a blood conduit. Preferably, the cylindrical case has two portions with different radii so that when the two portions are mated to enclose the hollow fiber bundle, crimping is achieved. In this way, shunting of blood is avoided by being forced to pass a crimped position between the inlet and outlet ports to more evenly distribute the blood among the fibers of the bundle. In another embodiment, a method for making an exchanger includes filling a chamber, integral to the exchanger, with uncured potting material. The exchanger is spun to distribute the uncured potting material about open ends of an encasement. After curing, a portion of the potting material and the hollow fiber bundle are trimmed away.

Abstract: A medical instrument and method is provided for defoaming or preventing formation of foam in blood during extracorporeal blood circulation. The method comprises durably coating hydrophobic blood-contact surfaces with a nontoxic, biocompatible surface-active defoaming agent.

Abstract: An integrated package suited to the packaging of medical devices and surgical equipment including devices and equipment used in heart by-pass surgery has a container and a snap-fit lid. The container and the lid have topographies suitable to conform to the medical components in the container and hold them securely. The lid has first and second grooves which engage a projection on the container and permit the lid to be used in a shipping orientation and a disposal orientation.

Abstract: An integrated package suited to the packaging of medical devices and surgical equipment including devices and equipment used in heart by-pass surgery has a container and a snap-fit lid. The container and the lid have topographies suitable to conform to the medical components in the container and hold them securely. The lid has first and second grooves which engage a projection on the container and permit the lid to be used in a shipping orientation and a disposal orientation.

Abstract: An improved perfusion control assembly comprising a console and an oxygenator flanked by at least two flanking units, wherein a first flanking unit is a pump assembly and additional flanking units are at least one of additional pump assemblies, a display monitor, a parameter monitoring assembly, or a controller, is described. The improved assembly can have the advantages of a reduced extracorporeal blood volumes in cardiopulmonary and cardioplegia circuits, and improved ergonomics for the perfusionist. In a preferred embodiment, the elongated console of the assembly is divided into a central and at least two peripheral segments connected by hinged joints. The perfusionist may rotate segments to create a cockpit shaped assembly.

Abstract: The instant invention is directed to a left ventricle valve for use in a left ventricle drain line. The left ventricle valve includes a unidirectional check valve having duckbill valve portion and a flange portion to movably cover vacuum vent openings. The vacuum vent openings are parallel to the flow passage of the left ventricle valve. The valve also has a pressure relief opening. The invention further contemplates the valve in an extracorporeal circuit for draining the left ventricle of a heart.

Abstract: A plunger assembly for obstructing the flow of fluid through a flexible tube is provided. The assembly comprises a plunger sleeve member having a first open end and a compression mechanism for selectively contacting and compressing the flexible tube. The compression mechanism has a contacting portion for contacting the flexible tube and an extending portion with the extending portion being slidably receivable within the plunger sleeve member through the first open end of the plunger sleeve member. A spring mechanism is mounted about the extending portion of the compression mechanism and between the contacting portion of the compression mechanism and the first open end of the plunger sleeve member for providing selective movement to the compression mechanism relative to the plunger sleeve member.

Abstract: An improved autologous blood salvage system is provided in which blood is removed from a patient and may be processed in a manner wherein an anticoagulant solution is for cycled for reuse. Further, the system may be employed for contemporaneous blood filtering and red blood separation. In one embodiment, anticoagulated blood is contemporaneously filtered and defoamed within a rotating processing bowl, while red blood cells are separated, washed and collected within the bowl and an anticoagulant solution is cycled from the bowl for re-use. During a red blood cell removal mode, the flow of anticoagulated blood into the bowl may be suspended/terminated and the bowl pressurized to remove the red blood cells. The improved system provides for the recovery of a high quality red blood cell product, with reduced processing time requirements/user training, and reduced disposable componentry and related costs.

Abstract: The surface free energy of a polymer blend where a base polymer contains an additive having a different surface free energy than that of the base polymer can be controlled over a wide range of additive surface concentrations by appropriate choice of the mold surface free energy during fabrication. A high surface concentration of additive relative to a low bulk concentration can be achieved, leading to improved biocompatibility without loss of optical clarity.

Abstract: A method and apparatus for preparing a cardioplegia mixture is provided which allows an increased level of control over the flow rate, dilution ration and concentration of cardioplegia inducing components in cardioplegia mixture during cardiovascular surgery. The method for preparing the cardioplegia mixture includes the steps of combining first and second crystalloid solutions of different concentrations to establish a total volume flow rate of combined solutions. The flow rate of the first crystalloid solution is self adjusted to equal the established total volume flow rate minus the established volume flow rate of the second crystalloid solution. The apparatus for preparing a cardioplegia mixture includes first and second crystalloid solutions containing a cardioplegia inducing component at different concentrations, and means for flowing and combining the solutions and establishing a total volume flow rate of the combined solution.

Abstract: A novel biocompatible anion exchange membrane is prepared by reacting the hydroxyl groups of a chromatographic support material with a polyester-cellulose solution containing glycidyl trimethyl ammonium chloride and bis glycidyl polyethylene oxide.