Abstract: A computerized publication management system and method of use are provided for managing the marketing communications development process for healthcare and other highly regulated entities. The method involves receiving a number of inputs that define a desired marketing communication via a graphical user interface of the publication management system. Based on an analysis of the inputs, the publication management system may determine a number of tasks to be completed over the course of a marketing communications project and assign each of the tasks to appropriate personnel and/or service groups within the entity. The tasks may include, for example, obtaining appropriate approvals, copywriting, editing and proofing, print vender selection and management, and so on. Using the tasks and their assignments, the system may determine a workflow path and timeline for the project and track and manage the completion of the project as it progresses through the workflow path.