Patents Assigned to CollaGenex Pharmaceuticals, Incorporated
  • 4-dedimethylaminotetracycline derivatives
    Patent number: 6894036
    Abstract: The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compounds include the 4-dedimethylaminotetracycline derivatives with an oxime group, NH-Alkyl, or N—NH-Alkyl group substituted at the C4 position as well as C2 Mannich derivatives. The present invention also provides a method of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the new chemically modified tetracycline compounds.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: May 17, 2005
    Assignee: CollaGenex Pharmaceuticals, Incorporated
    Inventors: Robert Ashley, Joseph J. Hlavka
  • 4-dedimethylaminotetracycline derivatives
    Patent number: 6638922
    Abstract: The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compounds include the 4-dedimethylaminotetracycline derivatives with an oxime group, NH-Alkyl, or N—NH-Alkyl group substituted at the C4 position as well as C2 Mannich derivatives. The present invention also provides a method of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the new chemically modified tetracycline compounds.
    Type: Grant
    Filed: July 24, 2001
    Date of Patent: October 28, 2003
    Assignee: CollaGenex Pharmaceuticals Incorporated
    Inventors: Robert Ashley, Joseph J. Hlavka