Patents Assigned to CollPlant Ltd.
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Publication number: 20240042099Abstract: The disclosure herein relates to photoinitiated dermal fillers, hyaluronic acid-rhCollagen double crosslinked dermal fillers and hyaluronic acid-rhCollagen semi interpenetrated network, each comprising plant-derived human collagen, as well as methods of using the same.Type: ApplicationFiled: October 12, 2023Publication date: February 8, 2024Applicant: CollPlant Ltd.Inventors: Oded SHOSEYOV, Nadav ORR, Jasmine SEROR MAKNOUZ, Revital ZARKA
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Patent number: 11801329Abstract: The disclosure herein relates to photoinitiated dermal fillers, hyaluronic acid-rhCollagen double crosslinked dermal fillers and hyaluronic acid-rhCollagen semi interpenetrated network, each comprising plant-derived human collagen, as well as methods of using the same.Type: GrantFiled: May 2, 2019Date of Patent: October 31, 2023Assignee: CollPlant Ltd.Inventors: Oded Shoseyov, Nadav Orr, Jasmine Seror Maknouz, Revital Zarka
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Publication number: 20230310704Abstract: A three-dimensional (3D) biocompatible, degradable soft tissue implant, comprising a bioprinted composite scaffold, the composite scaffold comprising a recombinant human collagen (rhCollagen) and a biocompatible synthetic polymer and features: a porous wall; an inner cavity at least partially enclosed within the porous wall; and at least one injection port that connects the inner cavity with an outer most surface of the scaffold, wherein the injection port has an opening sized to permit insertion of an injection device through the port, processes of preparing same and uses thereof in soft tissue reconstruction are provided. Injectable matrices for use in soft tissue reconstruction, either alone or in combination with the implant are also provided.Type: ApplicationFiled: March 22, 2021Publication date: October 5, 2023Applicant: CollPlant Ltd.Inventors: Nadav ORR, Miriam STERN, Revital ZARKA
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Publication number: 20210310082Abstract: Collagen producing plant events, DNA molecules for detecting same and uses thereof in plant breeding methods are provided.Type: ApplicationFiled: July 31, 2019Publication date: October 7, 2021Applicant: CollPlant Ltd.Inventors: Oded SHOSEYOV, Daphna MICHAELI, Itamar LUPO
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Patent number: 10799616Abstract: Disclosed herein is a compositions-of-matter comprising a cross-linked polymer, the cross-linked polymer comprising a plurality of resilin polypeptide moieties, and at least one polymeric moiety covalently cross-linked to a plurality of the resilin polypeptide moieties via at least one cross-linking moiety, the cross-linking moiety being devoid of a biphenyl moiety. Further disclosed herein is a process for preparing the composition-of-matter, a composite material comprising the composition-of-matter and at least one additional polymeric substance bound to the cross-linked polymer, an article-of-manufacturing comprising the composition-of-matter and/or composite material, and a method of treating tissue damage or loss by implanting said article-of-manufacturing in a subject.Type: GrantFiled: November 5, 2014Date of Patent: October 13, 2020Assignees: CollPlant Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventors: Oded Shoseyov, Sigal Meirovitch, Shaul Lapidot, Amit Rivkin
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Patent number: 10716876Abstract: A method of generating a collagen fiber is disclosed. Fibers generated thereby are also disclosed as well as scaffolds comprising such fibers.Type: GrantFiled: January 11, 2018Date of Patent: July 21, 2020Assignee: CollPlant Ltd.Inventors: Oded Shoseyov, Amit Yaari
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Publication number: 20200179562Abstract: Compositions containing curable recombinant human collagen, and kits comprising same, which are usable in preparing modeling material formulations for additive manufacturing (e.g., 3D bioprinting) of 3D objects are provided. Methods utilizing such modeling material formulations in additive manufacturing of 3D objects having a collagen-based material in at least a portion thereof, are also provided. The formulations feature a desired viscosity at a temperature higher than 10° C. (e.g., room temperature or 37° C.) and allow performing the additive manufacturing without cooling the system or a part thereof.Type: ApplicationFiled: June 8, 2018Publication date: June 11, 2020Applicant: CollPlant Ltd..Inventors: Oded SHOSEYOV, Nadav ORR, Jasmine SEROR MAKNOUZ, Revital ZARKA
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Patent number: 10626408Abstract: A method of producing collagen in a plant and plants producing collagen are provided. The method is effected by expressing in the plant at least one type of a collagen alpha chain in a manner enabling accumulation of the collagen alpha chain in a subcellular compartment devoid of endogenous P4H activity, thereby producing the collagen in the plant.Type: GrantFiled: October 3, 2017Date of Patent: April 21, 2020Assignee: CollPlant Ltd.Inventors: Oded Shoseyov, Hanan Stein
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Patent number: 10493134Abstract: A composition of matter is disclosed which comprises crosslinked collagen, platelet rich plasma (PRP) and an inorganic salt. Methods of generating same and uses thereof are also disclosed.Type: GrantFiled: March 19, 2014Date of Patent: December 3, 2019Assignee: CollPlant Ltd.Inventors: Racheli Gueta, Oded Shoseyov, Frida Grynspan Gotlieb, Ofer Levy
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Publication number: 20180044692Abstract: A method of producing collagen in a plant and plants producing collagen are provided. The method is effected by expressing in the plant at least one type of a collagen alpha chain in a manner enabling accumulation of the collagen alpha chain in a subcellular compartment devoid of endogenous P4H activity, thereby producing the collagen in the plant.Type: ApplicationFiled: October 3, 2017Publication date: February 15, 2018Applicant: CollPlant Ltd.Inventors: Oded SHOSEYOV, Hanan STEIN
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Patent number: 9783816Abstract: A method of producing collagen in a plant and plants producing collagen are provided. The method is effected by expressing in the plant at least one type of a collagen alpha chain in a manner enabling accumulation of the collagen alpha chain in a subcellular compartment devoid of endogenous P4H activity, thereby producing the collagen in the plant.Type: GrantFiled: July 8, 2013Date of Patent: October 10, 2017Assignee: CollPlant Ltd.Inventors: Oded Shoseyov, Hanan Stein
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Patent number: 9687583Abstract: Provided herein are polymers having the general formula I as defined herein, A-L-B??Formula I as well as crosslinked polymers having the general formula III: B?-L?-A?-A?-L?-B???Formula III and methods of preparing the polymers, wherein A is a dihydroxyphenyl moiety; A?-A? is a pair of crosslinked dihydroxyphenyl moieties; B, B? and B? are each a biopolymer; and L, L? and L? are each a linking moiety. Further provided are crosslinked adhesives prepared from the polymers, methods of generating same by oxidizing a polymer, and uses thereof. Further provided are kits comprising an adhesive and an oxidizing agent.Type: GrantFiled: August 30, 2012Date of Patent: June 27, 2017Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., CollPlant Ltd.Inventors: Oded Shoseyov, Shaul Lapidot, Amit Rivkin
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Publication number: 20160145311Abstract: Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.Type: ApplicationFiled: February 1, 2016Publication date: May 26, 2016Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., CollPlant Ltd.Inventors: Oded SHOSEYOV, Shaul LAPIDOT, Sigal MEIROVITCH, Daniel L. SIEGEL
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Patent number: 9273152Abstract: Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.Type: GrantFiled: December 8, 2014Date of Patent: March 1, 2016Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., CollPlant Ltd.Inventors: Oded Shoseyov, Shaul Lapidot, Sigal Meirovitch, Daniel L Siegel
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Publication number: 20150328288Abstract: A method of promoting wound healing, treating fibrosis and/or promoting angiogenesis is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a procollagen, thereby promoting wound healing, treating fibrosis and/or promoting angiogenesis in the subject.Type: ApplicationFiled: August 3, 2015Publication date: November 19, 2015Applicant: CollPlant Ltd.Inventors: Oded SHOSEYOV, Or Dgany, Daniel L Siegel
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Patent number: 9145463Abstract: Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.Type: GrantFiled: March 13, 2014Date of Patent: September 29, 2015Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., CollPlant Ltd.Inventors: Oded Shoseyov, Shaul Lapidot, Sigal Meirovitch, Daniel L. Siegel
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Patent number: 9095569Abstract: A method of promoting wound healing, treating fibrosis and/or promoting angiogenesis is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a procollagen, thereby promoting wound healing, treating fibrosis and/or promoting angiogenesis in the subject.Type: GrantFiled: April 16, 2009Date of Patent: August 4, 2015Assignee: CollPlant Ltd.Inventors: Oded Shoseyov, Or Dgany, Daniel L. Siegel
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Patent number: 8906651Abstract: Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.Type: GrantFiled: April 25, 2013Date of Patent: December 9, 2014Assignee: CollPlant Ltd.Inventors: Oded Shoseyov, Shaul Lapidot, Sigal Meirovitch, Daniel L. Siegel
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Publication number: 20140256641Abstract: Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.Type: ApplicationFiled: March 13, 2014Publication date: September 11, 2014Applicants: CollPlant Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventors: Oded SHOSEYOV, Shaul Lapidot, Sigal Meirovitch, Daniel L. Siegel
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Patent number: 8759487Abstract: A method of generating atelocollagen is disclosed. The method comprises contacting a human telopeptide-comprising collagen with a protease selected from the group consisting of neutrase, subtilisin, ficin recombinant human trypsin and recombinant human pepsin, wherein said human telopeptide-comprising collagen is expressed in a non-animal cell, thereby generating the atelocollagen. Compositions comprising the atelocollagen generated thereby are also disclosed.Type: GrantFiled: October 26, 2008Date of Patent: June 24, 2014Assignee: CollPlant Ltd.Inventors: Oded Shoseyov, Hanan Stein, Michal Rosenthal, Or Dgany, Tamar Haya Tal, Amit Yaari