Patents Assigned to Compound Therapeutics, Inc.
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Publication number: 20060270604Abstract: Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.Type: ApplicationFiled: July 7, 2006Publication date: November 30, 2006Applicant: Compound Therapeutics, Inc.Inventors: Dasa Lipovsek, Richard Wagner, Robert Kuimelis
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Publication number: 20060246059Abstract: Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.Type: ApplicationFiled: July 7, 2006Publication date: November 2, 2006Applicant: Compound Therapeutics, Inc.Inventors: Dasa Lipovsek, Richard Wagner, Robert Kuimelis
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Patent number: 7125669Abstract: Disclosed herein are methods for immobilizing a peptide or protein on a solid support. The method generally includes the following steps: (a) providing one or more templates attached to a solid support, wherein the one or more templates include (i) an RNA encoding a peptide and (ii) a peptide acceptor-linker linked to the RNA; and (b) subjecting the one or more templates to conditions that support translation and attachment of said peptide to said peptide acceptor, thereby synthesizing the one or more peptides on the solid support. Also disclosed herein are solid supports having at least one RNA-protein fusion component immobilized thereon, methods for generating protein arrays, and methods for screening molecules using these arrays.Type: GrantFiled: November 21, 2002Date of Patent: October 24, 2006Assignee: Compound Therapeutics, Inc.Inventor: Markus Kurz
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Patent number: 7115396Abstract: Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.Type: GrantFiled: December 3, 2003Date of Patent: October 3, 2006Assignee: Compound Therapeutics, Inc.Inventors: Dasa Lipovsek, Richard W. Wagner, Robert G. Kuimelis
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Patent number: 7078197Abstract: Described herein are methods and reagents for the ligation of a peptide acceptor to an RNA, as well as the RNA-peptide acceptor products.Type: GrantFiled: July 30, 2002Date of Patent: July 18, 2006Assignee: Compound Therapeutics, Inc.Inventors: Markus Kurz, Peter Lohse, Richard Wagner
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Patent number: 7022479Abstract: Disclosed herein are methods for detecting multiple compounds in a sample, involving: (a) contacting the sample with a mixture of binding reagents, the binding reagents being nucleic acid-protein fusions, each having (i) a protein portion which is known to specifically bind to one of the compounds and (ii) a nucleic acid portion which encodes the protein portion and which includes a unique identification tag; (b) allowing the protein portions of the binding reagents and the compounds to form complexes; (c) capturing the binding reagent-compound complexes; (d) amplifying the nucleic acid portions of the complexed binding reagents; and (e) detecting the unique identification tag of each of the amplified nucleic acids, thereby detecting the corresponding compounds in the sample. Also disclosed herein are kits for carrying out such methods.Type: GrantFiled: August 5, 2002Date of Patent: April 4, 2006Assignee: Compound Therapeutics, Inc.Inventor: Richard W. Wagner
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Patent number: 6951725Abstract: Disclosed herein are in vitro assays for the identification of interactions between proteins or other molecules, the identification of transcriptional activator proteins, and the detection of compounds that inhibit protein/protein or protein/compound interactions. Also disclosed herein are in vitro assays for the selection of interacting proteins and transcriptional activator proteins out of libraries.Type: GrantFiled: June 20, 2002Date of Patent: October 4, 2005Assignee: Compound Therapeutics, Inc.Inventors: Markus Kurz, Peter Lohse
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Publication number: 20050074865Abstract: Disclosed is a family of novel protein constructs, useful as drugs and for other purposes, termed “adzymes,” comprising an address moiety and a catalytic domain. In some types of disclosed adzymes, the address binds with a binding site on or in functional proximity to a targeted biomolecule, e.g., an extracellular targeted biomolecule, and is disposed adjacent the catalytic domain so that its affinity serves to confer a new specificity to the catalytic domain by increasing the effective local concentration of the target in the vicinity of the catalytic domain. The present invention also provides pharmaceutical compositions comprising these adzymes, methods of making adzymes, DNA's encoding adzymes or parts thereof, and methods of using adzymes, such as for treating human subjects suffering from a disease, such as a disease associated with a soluble or membrane bound molecule, e.g., an allergic or inflammatory disease.Type: ApplicationFiled: March 2, 2004Publication date: April 7, 2005Applicant: COMPOUND THERAPEUTICS, INC.Inventors: Noubar Afeyan, Frank Lee, Gordon Wong, Ruchira Das Gupta, Brian Baynes
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Publication number: 20040259155Abstract: The present invention provides, among other things, methods for engineering a spatially conserved motifs into a recipient polypeptide or polypeptide complex that does not naturally contain such a motif.Type: ApplicationFiled: September 30, 2003Publication date: December 23, 2004Applicant: Compound Therapeutics, Inc.Inventors: John Chan, Shengsheng Zhang, Brian Baynes
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Patent number: 6818418Abstract: Disclosed herein are proteins that include a fibronectin type III domain having at least one randomized loop. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.Type: GrantFiled: February 29, 2000Date of Patent: November 16, 2004Assignee: Compound Therapeutics, Inc.Inventors: Dasa Lipovsek, Richard W. Wagner, Robert G. Kuimelis