Abstract: A technique is disclosed for generating a new contour and/or a 3D surface from contour data using a surface displacement field. The technique is preferably applied to un-contoured target images within a 4D image sequence for which contour data is desired. The technique can be initialized with contour data related to a reference image that has already been contoured, e.g. by a doctor who manually enters contour information into a computer. Image registration (calculation of correspondence between the reference image and target image) can be performed simultaneously with segmentation (identifying regions of interest in the target image). This allows one to make use of segmentation information in a reference image to improve the accuracy of contouring within the target image.

Abstract: A technique is disclosed for generating a new contour and/or a 3D surface such as a variational implicit surface from contour data. In one embodiment, B-spline interpolation is used to efficiently generate a new contour (preferably a transverse contour), from a plurality of input contours (preferably, sagittal and/or coronal contours). In another embodiment, a point reduction operation is performed on data sets corresponding to any combination of transverse, sagittal, or coronal contour data prior to processing those data sets to generate a 3D surface such as a variational implicit surface. A new contour can also be generated by the intersection of this surface with an appropriately placed and oriented plane. In this manner, the computation of the variational implicit surface becomes sufficiently efficient to make its use for new contour generation practical.

Abstract: An improved system and method for optimizing the planning, registration, targeting, and delivery of conformal, external beam radiation therapy of prostate cancer and other soft-tissue diseases. Real-time ultrasound imaging during planning and treatment is used forlocalization of soft tissue treatment targets and fused with radiographic or CT data for conformal treatment optimization. The fusion technique provides accurate localization of the prostate volume in real time. For treatment of prostate cancer, visualization of the prostate gland is achieved using transrectal ultrasonography and the fusion of that image in the precise location of the prostate within the pelvic region, accurately determining the location of the prostate target by transformation of the ultrasound image data on both the ultrasound and X-ray/CT images.

Abstract: A method and system for monitoring loading of radiation into an insertion device for use in a radiation therapy treatment to determine whether the treatment will be in agreement with a radiation therapy plan. In a preferred embodiment, optical sensors and radiation sensors are used to monitor loading of radioactive seeds and spacers into a needle as part of a prostate brachytherapy treatment.

Abstract: A method of approximating the boundary of an object in an image, the image being represented by a data set, the data set comprising a plurality of data elements, each data element having a data value corresponding to a feature of the image, the method comprising determining which one of a plurality of contours most closely matches the object boundary at least partially according to a divergence value for each contour, the divergence value being selected from the group consisting of Jensen-Shannon divergence and Jensen-Renyi divergence. Each contour Ci defines a zone ZIi and a zone ZOi, ZIi representing the data elements inside the contour and ZOi representing the data elements outside the contour, each zone having a corresponding probability distribution of data values for the data elements therein, and wherein the divergence value for each contour Ci represents a measure of the difference between the probability distributions for the zones ZIi and ZOi.

Abstract: A method and apparatus for three-dimensional imaging and treatment of a patient's body. The method and apparatus utilize a system for developing a therapy plan for treatment of an organ of the patient, a device for generating ultrasound image data from a treatment region and a device for providing a translucent volume image of a portion of a patient's body and a separate translucent image of the patient organ and a three dimensional viewing device to superimpose a translucent article image to enable viewing of the article image simultaneously with the patient organ and a portion of the patient's body.

Abstract: An improved system and method for optimizing the planning, registration, targeting, and delivery of conformal, external beam radiation therapy of prostate cancer and other soft-tissue diseases. Real-time ultrasound imaging during planning and treatment is used for localization of soft tissue treatment targets and fused with radiographic or CT data for conformal treatment optimization. The fusion technique provides accurate localization of the prostate volume in real time. For treatment of prostate cancer, visualization of the prostate gland is achieved using transrectal ultrasonography and the fusion of that image in the precise location of the prostate within the pelvic region, accurately determining the location of the prostate target by transformation of the ultrasound image data on both the ultrasound and X-ray/CT images.

Abstract: A method and apparatus for three-dimensional imaging and treatment of a patient's body. The method and apparatus utilize a system for developing a therapy plan for treatment of an organ of the patient, a device for generating ultrasound image data from a treatment region and a device for providing a translucent volume image of a portion of a patient's body and a separate translucent image of the patient organ and a three dimensional viewing device to superimpose a translucent article image to enable viewing of the article image simultaneously with the patient organ and a portion of the patient's body.

Abstract: A system and method for autofusion of three-dimensional (“3-D”) image data volumes is described. According to the system and method, registration is effected by simultaneously displaying on a GUI at least, but preferably, two 3-D, image data volumes, and one of the 3-D image data volumes is held fixed while the other may be scaled, rotated, and translated to align homologous anatomic features. The system and method will simultaneously display the axial, sagittal, and coronal plane views of a region of interest These plane views will be of data volumes that are designed and configured for a system user to “drag” or “position” one volume to a new position in one plane view which will also simultaneously update the data volume in the other two plane views with no apparent lag time. The system and method also includes automated alignment computation based on mutual information (“MI”) maximization.

Abstract: A system and method is disclosed for automatically computing contours representing the boundaries of objects in three-dimensional tomographic images that may be formed by computed tomography (“CT”), magnetic resonance imaging (“MRI”), positron emission tomography (“PET”), single proton emission computed tomography (“SPECT”), or other appropriate methods. The system and method begin with a sample region of the object's interior and the single region is expanded in a step-wise fashion. At each step, a contour maximally matching the region's current edge, local gray-level gradient maxima, and prior contour shapes is determined. Upon completion of region expansion, the object contour is set to that step-contour having the maximum value of an objective function summing contributions from region edges, gradient edges, and prior shapes.