Patents Assigned to CONFLUENCE LIFE SCIENCES, INC.
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Patent number: 9695200Abstract: Disclosed herein are heterocyclic compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of Formula (I): wherein R1, R2, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.Type: GrantFiled: January 25, 2016Date of Patent: July 4, 2017Assignee: Confluence Life Sciences, Inc.Inventors: Eric Jon Jacobsen, James Robert Blinn, John Robert Springer, Susan L. Hockerman
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Patent number: 9636333Abstract: The present disclosure provides methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, including rheumatoid arthritis, having the structure of Formula (I): wherein R1, R2, R3, R4, R5 and X are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.Type: GrantFiled: August 7, 2015Date of Patent: May 2, 2017Assignee: CONFLUENCE LIFE SCIENCES, INC.Inventors: Susan L. Hockerman, Joseph B. Monahan, Shaun R. Selness
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Patent number: 9505765Abstract: 4-alkoxy/aralkoxy-5-substituted-pyrrolopyrimidine compounds, pharmaceutically acceptable salts, solvates and pharmaceutical compositions of compounds embraced by Formula (I), provide a therapeutic benefit to subjects with disease conditions, especially cancer, wherein R1 and R2 are as defined in the detailed description.Type: GrantFiled: July 26, 2013Date of Patent: November 29, 2016Assignee: CONFLUENCE LIFE SCIENCES INC.Inventors: Eric Jonathan Jacobsen, John Robert Springer, James Robert Blinn, Balekudru Devadas
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Patent number: 9499551Abstract: Disclosed herein are substituted pyrrolopyridine and pyrrolopyrazine compounds and compositions useful in the treatment of TAK mediated diseases, such as cancer, having the structure of Formula (I): wherein R1, R2, R3, and R4 are as defined in the detailed description. Methods of modulation of TAK activity in a human or animal subject are also provided, providing therapeutic benefit to subjects with disease conditions, especially cancer.Type: GrantFiled: January 23, 2015Date of Patent: November 22, 2016Assignee: Confluence Life Sciences, Inc.Inventors: Eric Jon Jacobsen, James Robert Blinn, John Robert Springer, Susan L. Hockerman
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Patent number: 9365547Abstract: The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4, R5, X and Y are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.Type: GrantFiled: January 7, 2014Date of Patent: June 14, 2016Assignee: CONFLUENCE LIFE SCIENCES INC.Inventors: Shaun R. Selness, Joseph B. Monahan, John F. Schindler, Balekudru Devadas
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Patent number: 9365546Abstract: The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4, R5, X and Y are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.Type: GrantFiled: January 7, 2014Date of Patent: June 14, 2016Assignee: CONFLUENCE LIFE SCIENCES INC.Inventors: Shaun R. Selness, Joseph B. Monahan, John F. Schindler, Balekudru Devadas
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Patent number: 9359300Abstract: The present disclosure provides methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3 and X are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.Type: GrantFiled: June 7, 2013Date of Patent: June 7, 2016Assignee: CONFLUENCE LIFE SCIENCES, INC.Inventors: Shaun R. Selness, Joseph B. Monahan, John F. Schindler, Balekudru Devadas, Susan L. Hockerman
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Patent number: 9145393Abstract: Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of Formula (I): wherein Ar, R2, R4, R5, n and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.Type: GrantFiled: January 23, 2015Date of Patent: September 29, 2015Assignee: Confluence Life Sciences, Inc.Inventors: Eric Jon Jacobsen, James Robert Blinn
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Patent number: 9115089Abstract: The present disclosure provides methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, including rheumatoid arthritis, having the structure of Formula (I): wherein R1, R2, R3, R4, R5 and X are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.Type: GrantFiled: June 6, 2014Date of Patent: August 25, 2015Assignee: CONFLUENCE LIFE SCIENCES, INC.Inventors: Susan L. Hockerman, Joseph B. Monahan, Shaun R. Selness
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Patent number: 9056110Abstract: The present disclosure provides pyrimidinone-phenyl-pyrimidinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4 and R5 are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.Type: GrantFiled: December 6, 2012Date of Patent: June 16, 2015Assignee: CONFLUENCE LIFE SCIENCES, INC.Inventors: Shaun R. Selness, Balekudru Devadas, Susan L. Hockerman, Joseph B. Monahan
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Publication number: 20140171449Abstract: The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4, R5, X and Y are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.Type: ApplicationFiled: January 7, 2014Publication date: June 19, 2014Applicant: CONFLUENCE LIFE SCIENCES INC.Inventors: Shaun R. Selness, Joseph B. Monahan, John F. Schindler, Balekudru Devadas
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Publication number: 20140171450Abstract: The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4, R5, X and Y are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.Type: ApplicationFiled: January 7, 2014Publication date: June 19, 2014Applicant: CONFLUENCE LIFE SCIENCES INC.Inventors: Shaun R. Selness, Joseph B. Monahan, John F. Schindler, Balekudru Devadas
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Patent number: 8563558Abstract: The present disclosure provides pyridine urea compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4, R5, V and W are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.Type: GrantFiled: December 6, 2011Date of Patent: October 22, 2013Assignee: Confluence Life Sciences, Inc.Inventors: Shaun R. Selness, Joseph B. Monahan, John F. Schindler, Balekudru Devadas, Susan L. Hockerman
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Patent number: 8507499Abstract: The present disclosure provides indole/indazole-pyrimidinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein W, X, R1, R2, R3, R4, R5 and R6 are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.Type: GrantFiled: December 6, 2011Date of Patent: August 13, 2013Assignee: Confluence Life Sciences, Inc.Inventors: Shaun R. Selness, Joseph B. Monahan, John F. Schindler, Balekudru Devadas
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Publication number: 20130143906Abstract: The present disclosure provides pyrimidinone-phenyl-pyrimidinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4 and R5 are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.Type: ApplicationFiled: December 6, 2012Publication date: June 6, 2013Applicant: CONFLUENCE LIFE SCIENCES, INC.Inventor: CONFLUENCE LIFE SCIENCES, INC.