Patents Assigned to Corixa Corporation
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Patent number: 7563880
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: July 21, 2009
    Assignee: Corixa Corporation
    Inventors: Davin C Dillon, Yuqiu Jiang
  • WT1 fusion proteins
    Patent number: 7553494
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: June 30, 2009
    Assignee: Corixa Corporation
    Inventors: Alexander Gaiger, Patricia D McNeill, Nomalie Jaya
  • COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE
    Publication number: 20090142778
    Abstract: Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
    Type: Application
    Filed: February 25, 2008
    Publication date: June 4, 2009
    Applicant: Corixa Corporation
    Inventors: Robert M. Hershberg, Nancy Ann Hosken, Michael J. Lodes, Raodoh Mohamath, Stephan R. Targan
  • Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
    Patent number: 7541020
    Abstract: Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosaminide ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for using the compounds as adjuvants and immunoeffectors are also disclosed.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: June 2, 2009
    Assignee: Corixa Corporation
    Inventors: David A Johnson, C Gregory Sowell
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Patent number: 7517952
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: April 14, 2009
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day, Thomas S. Vedvick, Darrick Carter, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky, William T. Hepler, Robert A. Henderson
  • Immunoeffector compounds
    Patent number: 7501399
    Abstract: This invention provides compounds containing a 2-deoxy-2-amino-?-D-glucopyranose (glucosamine) glycosidically linked to an cyclic aminoalkyl (aglycon) group. The invention further provides methods for inducing an immune response using the compounds of the present invention in the presence or absence of an antigen. In addition, methods for treating disease with the compounds of the present invention with or without an antigen are also provided in this invention.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: March 10, 2009
    Assignee: Corixa Corporation
    Inventors: David A. Johnson, Jory Baldridge, C. Gregory Sowell
  • COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF LUNG CANCER
    Publication number: 20090062194
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: October 30, 2007
    Publication date: March 5, 2009
    Applicant: CORIXA CORPORATION
    Inventors: Tongtong Wang, Robert A. Henderson, Teresa M. Foy, Patricia D. McNeill, Yoshihiro Watanabe, Michael D. Kalos, Gary R. Fanger, Chaitanya S. Bangur
  • COMPOUNDS AND METHODS FOR TREATMENT AND DIAGNOSIS OF CHLAMYDIAL INFECTION
    Publication number: 20090047283
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Application
    Filed: October 30, 2007
    Publication date: February 19, 2009
    Applicant: CORIXA CORPORATION
    Inventors: Ajay Bhatia, Jeff Guderian, Yasir A. W. Skeiky, Jean-Francois L. Maisonneuve
  • COMPOUNDS AND METHODS FOR TREATMENT AND DIAGNOSIS OF CHLAMYDIAL INFECTION
    Publication number: 20090035296
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Application
    Filed: October 30, 2007
    Publication date: February 5, 2009
    Applicant: CORIXA CORPORATION
    Inventors: Ajay Bhatia, Yasir A. W. Skeiky, Peter Probst
  • COMPOUNDS AND METHODS FOR TREATMENT AND DIAGNOSIS OF CHLAMYDIAL INFECTION
    Publication number: 20090028887
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Application
    Filed: October 30, 2007
    Publication date: January 29, 2009
    Applicant: CORIXA CORPORATION
    Inventors: Ajay Bhatia, Yasir A.W. Skeiky, Peter Probst
  • COMPOUNDS AND METHODS FOR DIAGNOSIS AND IMMUNOTHERAPY OF TUBERCULOSIS
    Publication number: 20090022742
    Abstract: Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
    Type: Application
    Filed: October 30, 2007
    Publication date: January 22, 2009
    Applicant: Corixa Corporation
    Inventors: Antonio Campos-Neto, Yasir Skeiky, Pamela Ovendale, Shyian Jen, Michael Lodes
  • VACCINES AGAINST CHLAMYDIAL INFECTION
    Publication number: 20090022755
    Abstract: The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
    Type: Application
    Filed: March 24, 2006
    Publication date: January 22, 2009
    Applicants: GLAXOSMITHKLINE BIOLOGICALS SA, CORIXA CORPORATION
    Inventors: Brenda Barth, Ajay Bhatia, Mark Alderson, Jean-Francois L. Maisonneuve, Yves Lobet, Florence Bernadette Nozay, Martine Marchand, Pascal Mettens, Yasir A. Skeiky, Peter Probst
  • Compounds and methods for immunotherapy and diagnosis of tuberculosis
    Publication number: 20090017077
    Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
    Type: Application
    Filed: October 29, 2007
    Publication date: January 15, 2009
    Applicant: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. W. Skeiky, Davin C. Dillon, Antonio Campos-Neto, Raymond Houghton, Thomas S. Vedvick, Daniel T. Twardzik
  • Fusion proteins of mycobacterium tuberculosis
    Publication number: 20090018095
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: October 30, 2007
    Publication date: January 15, 2009
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Fusion proteins of mycobacterium tuberculosis
    Publication number: 20090004226
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: October 30, 2007
    Publication date: January 1, 2009
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • COMPOUNDS AND METHODS FOR TREATMENT AND DIAGNOSIS OF CHLAMYDIAL INFECTION
    Publication number: 20080317772
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Application
    Filed: October 30, 2007
    Publication date: December 25, 2008
    Applicant: CORIXA CORPORATION
    Inventors: Ajay Bhatia, Yasir A.W. Skeiky, Peter Probst
  • Fusion proteins of mycobacterium tuberculosis
    Publication number: 20080317716
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: October 30, 2007
    Publication date: December 25, 2008
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF COLON CANCER
    Publication number: 20080317755
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.
    Type: Application
    Filed: June 25, 2007
    Publication date: December 25, 2008
    Applicant: CORIXA CORPORATION
    Inventors: Gordon E. King, Madeleine Joy Braun, Jiangchun Xu, Heather Secrist
  • COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF BREAST CANCER
    Publication number: 20080311124
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: October 30, 2007
    Publication date: December 18, 2008
    Applicant: CORIXA CORPORATION
    Inventors: Gary R. Fanger, Shannon Kathleen Hirst, Davin C. Dillon, Teresa M. Foy, Raymond L. Houghton, David H. Persing, Michael D. Kalos
  • COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF BREAST CANCER
    Publication number: 20080311109
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: October 30, 2007
    Publication date: December 18, 2008
    Applicant: CORIXA CORPORATION
    Inventors: Steven G. Reed, Jiangchun Xu, Davin C. Dillon, Marc W. Retter, Susan L. Harlocker