Patents Assigned to CorTechs
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Patent number: 10762633Abstract: The disclosed technology relates generally to medical imaging, and more particularly, some embodiments relate to systems and methods for creating and using a covariate modulated or “dynamic” atlas. Some embodiments of the disclosure provide a method for predicting an alas using General Additive Model (GAM) parameters, wherein the GAM parameters are derived by registering (and optionally segmenting) a plurality of image data sets from a plurality of different subjects to an initial atlas estimate (e.g., a seed atlas), and analyzing the resulting registration, segmentation, and intensity parameters as correlated with input covariates.Type: GrantFiled: May 17, 2019Date of Patent: September 1, 2020Assignee: CORTECHS LABS, INC.Inventors: Sebastian Magda, Christopher N. Airriess, Nathan S. White
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Patent number: 10297025Abstract: The disclosed technology relates generally to medical imaging, and more particularly, some embodiments relate to systems and methods for creating and using a covariate modulated or “dynamic” atlas. Some embodiments of the disclosure provide a method for predicting an alas using General Additive Model (GAM) parameters, wherein the GAM parameters are derived by registering (and optionally segmenting) a plurality of image data sets from a plurality of different subjects to an initial atlas estimate (e.g., a seed atlas), and analyzing the resulting registration, segmentation, and intensity parameters as correlated with input covariates.Type: GrantFiled: November 10, 2017Date of Patent: May 21, 2019Assignee: CORTECHS LABS, INC.Inventors: Sebastian Magda, Christopher N. Airriess, Nathan S. White
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Patent number: 9818191Abstract: The disclosed technology relates generally to medical imaging, and more particularly, some embodiments relate to systems and methods for creating and using a covariate modulated or “dynamic” atlas. Some embodiments of the disclosure provide a method for predicting an alas using General Additive Model (GAM) parameters, wherein the GAM parameters are derived by registering (and optionally segmenting) a plurality of image data sets from a plurality of different subjects to an initial atlas estimate (e.g., a seed atlas), and analyzing the resulting registration, segmentation, and intensity parameters as correlated with input covariates.Type: GrantFiled: March 31, 2016Date of Patent: November 14, 2017Assignee: CorTechs Labs, Inc.Inventors: Sebastian Magda, Christopher N. Airriess, Nathan S. White
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Publication number: 20120288174Abstract: The present invention provides an atlas comprising values representative of magnetic resonance properties of a magnetic resonance (MR) scan and optionally, prior probability data relating to tissue type. Further embodiments of the invention involve a system including an MR scanner and the atlas for use in alignment of an MR scan, such as a localizer scan, to obtain a specific geometry of the data acquired during a subsequent scan. Also, a system includes an MR scanner and the atlas for automatic segmentation of an MR scan. Methods of making and using the atlas and system are also provided.Type: ApplicationFiled: March 2, 2012Publication date: November 15, 2012Applicant: CORTECHS LABS, INC.Inventors: Anders Dale, Sebastian Gicquel
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Patent number: 8140144Abstract: The present invention provides an atlas comprising values representative of magnetic resonance properties of a magnetic resonance (MR) scan and optionally, prior probability data relating to tissue type. Further embodiments of the invention involve a system including an MR scanner and the atlas for use in alignment of an MR scan, such as a localizer scan, to obtain a specific geometry of the data acquired during a subsequent scan. Also, a system includes an MR scanner and the atlas for automatic segmentation of an MR scan. Methods of making and using the atlas and system are also provided.Type: GrantFiled: December 7, 2007Date of Patent: March 20, 2012Assignee: CorTechs Labs, Inc.Inventors: Anders Dale, Sebastien Gicquel
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Publication number: 20080154118Abstract: The present invention provides an atlas comprising values representative of magnetic resonance properties of a magnetic resonance (MR) scan and optionally, prior probability data relating to tissue type. Further embodiments of the invention involve a system including an MR scanner and the atlas for use in alignment of an MR scan, such as a localizer scan, to obtain a specific geometry of the data acquired during a subsequent scan. Also, a system includes an MR scanner and the atlas for automatic segmentation of an MR scan. Methods of making and using the atlas and system are also provided.Type: ApplicationFiled: December 7, 2007Publication date: June 26, 2008Applicant: CorTechs Labs, Inc.Inventors: Anders Dale, Sebastian Gicquel
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Patent number: 7324842Abstract: The present invention provides an atlas comprising values representative of magnetic resonance properties of a magnetic resonance (MR) scan and optionally, prior probability data relating to tissue type. Further embodiments of the invention involve a system including an MR scanner and the atlas for use in alignment of an MR scan, such as a localizer scan, to obtain a specific geometry of the data acquired during a subsequent scan. Also, a system includes an MR scanner and the atlas for automatic segmentation of an MR scan. Methods of making and using the atlas and system are also provided.Type: GrantFiled: January 22, 2002Date of Patent: January 29, 2008Assignee: CorTechs Labs, Inc.Inventors: Anders Dale, Sébastien Gicquel
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Patent number: 6777403Abstract: Therefore, it is critical that the roles these enzymes play in biological processes outside of extracellular matrix degradation or remodeling be understood in order to assess their potential as targets for therapeutic intervention, and to design safe, conveniently produced, orally active inhibitors. Elastase inhibitors can differ with respect to their ability to inhibit different elastases. As a result, the spectrum of elastases inhibited by a specific drug candidate as well as the spectrum of activities these enzymes have with respect to proteins other than elastin are properties to consider in evaluating the drug candidates.Type: GrantFiled: December 23, 2002Date of Patent: August 17, 2004Assignee: Cortech, Inc.Inventor: John C. Cheronis
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Patent number: 6656911Abstract: The present invention relates to certain substituted oxadiazole, thiadiazoles and triazole peptoids which are useful as inhibitors of serine proteases. Compounds of the invention are useful for treating, for example, adult respiratory distress syndrome, septic shock, and myocardial ischemia-reperfusion injury.Type: GrantFiled: April 18, 2002Date of Patent: December 2, 2003Assignee: Cortech, Inc.Inventors: Albert Gyorkos, Lyle W Spruce
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Patent number: 6656910Abstract: The present invention relates to certain substituted oxadiazole, thiadiazoles and triazole peptoids which are useful as inhibitors of serine proteases. Compounds of the invention are useful for treating, for example, adult respiratory distress syndrome, septic shock, and myocardial ischemia-reperfusion injury.Type: GrantFiled: August 10, 2001Date of Patent: December 2, 2003Assignee: Cortech, Inc.Inventors: Albert Gyorkos, Lyle W. Spruce
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Publication number: 20030203851Abstract: The present invention relates to certain substituted oxadiazole, thiadiazoles and triazole peptoids which are useful as inhibitors of serine proteases. Compounds of the invention are useful for treating, for example, adult respiratory distress syndrome, septic shock, and myocardial ischemia-reperfusion injury.Type: ApplicationFiled: April 18, 2002Publication date: October 30, 2003Applicant: Cortech, Inc.Inventors: Albert Gyorkos, Lyle W. Spruce
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Patent number: 6608175Abstract: Certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases, are prepared in various embodiments using Grignard reagents and alkyllithium reagents and various aldehydes to make oxadiazole, thiadiazole and triazole peptoid alcohols, which are then oxidized to the desired keto products.Type: GrantFiled: November 16, 2001Date of Patent: August 19, 2003Assignee: Cortech, Inc.Inventors: Albert Gyorkos, Lyle W. Spruce
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Publication number: 20030139659Abstract: The present invention provides an atlas comprising values representative of magnetic resonance properties of a magnetic resonance (MR) scan and optionally, prior probability data relating to tissue type. Further embodiments of the invention involve a system including an MR scanner and the atlas for use in alignment of an MR scan, such as a localizer scan, to obtain a specific geometry of the data acquired during a subsequent scan. Also, a system includes an MR scanner and the atlas for automatic segmentation of an MR scan. Methods of making and using the atlas and system are also provided.Type: ApplicationFiled: January 22, 2002Publication date: July 24, 2003Applicant: CorTechsInventors: Anders Dale, Sebastien Gicquel
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Patent number: 6548638Abstract: The present invention relates to certain substituted oxadiazole peptoids and nonpeptoids useful as inhibitors of serine proteases, especially human neutophil elastase (HNE). Compounds of the present invention are useful for the treatment or amelioration of symptoms of adult respiratory distress syndrome, septic shock, and multiple organ failure. Processes mediated by HNE are also implicated in conditions such as arthritis, periodontal disease, glomerulonephritis, and cystic fibrosis.Type: GrantFiled: April 26, 2001Date of Patent: April 15, 2003Assignee: Cortech, Inc.Inventors: Albert Gyorkos, Lyle Spruce, Kazuyuki Ohmoto, Kazuhito Kawabata
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Patent number: 6255453Abstract: The present invention relates to certain substituted oxadiazole peptoids and nonpeptoids useful as inhibitors of serine proteases, especially human neutophil elastase (HNE). Compounds of the present invention are useful for the treatment or amelioration of symptoms of adult respiratory distress syndrome, septic shock, and multiple organ failure. Processes mediated by HNE are also implicated in conditions such as arthritis, periodontal disease, glomerulonephritis, and cystic fibrosis.Type: GrantFiled: June 3, 1999Date of Patent: July 3, 2001Assignee: Cortech, Inc.Inventors: Albert Gyorkos, Lyle Spruce, Kazuyuki Ohmoto, Kazuhito Kawabata
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Patent number: 6159938Abstract: Provided are methods of inhibiting the activity of a serine protease using protease inhibitors that include an alpha-keto heterocycle in their structure. The methods are useful in the treatment of ischemic heart or treatment of symptoms associated with blood coagulation disorders. Also provided are methods for detecting or quantifying the activity of a serine protease in a pure sample.Type: GrantFiled: May 20, 1997Date of Patent: December 12, 2000Assignee: Cortech, Inc.Inventors: Albert C. Gyorkos, Lyle W. Spruce, Axel H. Leimer, John C. Cheronis
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Patent number: 6150334Abstract: The present invention relates to certain compounds comprising substituted oxadiazole, thiadiazole and triazole structures which are useful as inhibitors of serine proteases, including human neutrophil elastase (HNE). Compounds described herein are characterized by their relatively low molecular weight, high potency and selectivity with respect to HNE, and can be used to effectively prevent, alleviate or otherwise treat disease states characterized by the degradation of connective tissue by proteases in humans.Type: GrantFiled: December 4, 1997Date of Patent: November 21, 2000Assignee: Cortech, Inc.Inventors: Albert C. Gyorkos, Lyle W. Spruce
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Patent number: 6100238Abstract: The present invention relates to certain substituted oxadiazole nonpeptides, which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septic shock and multiple organ failure. A series of studies also have indicated the involvement HNE in myocardial ischemia-reperfusion injury, emphysema. HNE-mediated processes are implicated in other conditions such as arthritis, periodontal disease, glomerulonephritis, dermatitis, psoriasis, cystic fibrosis, chronic bronchitis, atherosclerosis, Alzheimer's disease, organ transplantation, corneal ulcers, and invasion behavior of malignant tumors.Type: GrantFiled: June 3, 1998Date of Patent: August 8, 2000Assignee: Cortech Inc.Inventors: Albert C. Gyorkos, Lyle W. Spruce
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Patent number: 6075120Abstract: A bradykinin antagonist of the formula:(BKAn)(X)(Y)where BKAn is a bradykinin antagonist peptide; Y is a pharmacore; and X is a bridging link chemically joining the BKAn and Y components.Type: GrantFiled: May 12, 1995Date of Patent: June 13, 2000Assignee: Cortech, Inc.Inventors: John C. Cheronis, James K. Blodgett, Val Smith Goodfellow, Manoj Vinayak Marathe, Lyle W. Spruce, Eric T. Whalley
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Patent number: 6037325Abstract: The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases including human neutrophil elastase, equivalently known as human leukocyte elastase.Type: GrantFiled: April 30, 1998Date of Patent: March 14, 2000Assignee: Cortech, Inc.Inventors: Albert Gyorkos, Lyle W. Spruce