Patents Assigned to Corum Inc.
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Patent number: 11459288Abstract: A process for preparing azelaic acid is disclosed. In particular, the process for preparing azelaic acid is an ozone free process. The process for preparing azelaic acid comprises a step of decarboxylation of tetra-carboxylic acid in the presence of a organic sulfonic acid.Type: GrantFiled: July 20, 2020Date of Patent: October 4, 2022Assignee: CORUM INC.Inventor: Nai-Hsuan Hsu
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Patent number: 8927767Abstract: This invention discloses novel crystalline polymorphs of acetyl-glycine-beta-alanine and process of making the same. The mentioned crystalline polymorphs can exhibit excellent purity and storage stability according to this invention. Therefore, the mentioned crystalline polymorphs can be applied in topical cosmetic compositions, pharmaceutical compositions as skin care preparations, or other functional preparations.Type: GrantFiled: May 6, 2014Date of Patent: January 6, 2015Assignee: Corum Inc.Inventor: Nai-Hsuan Hsu
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Patent number: 8927499Abstract: The invention provides a method for inhibiting melanin formation composition by applying a glycine derivative, having a structure shown in the following general equation (I): wherein R1 represents a C1˜C4 alkyl group; R2 represents a hydrogen atom or a methyl group; and n represents an integer of 1˜6.Type: GrantFiled: January 21, 2014Date of Patent: January 6, 2015Assignee: Corum Inc.Inventors: Nai-Hsuan Hsu, Chiao-Yi Hsu, Ssu-Ching Wang, Ting-Wan Chen, Chu-Yi Pang
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Publication number: 20140336413Abstract: This invention discloses novel crystalline polymorphs of acetyl-glycine-beta-alanine and process of making the same. The mentioned crystalline polymorphs can exhibit excellent purity and storage stability according to this invention. Therefore, the mentioned crystalline polymorphs can be applied in topical cosmetic compositions, pharmaceutical compositions as skin care preparations, or other functional preparations.Type: ApplicationFiled: May 6, 2014Publication date: November 13, 2014Applicant: CORUM INC.Inventor: Nai-Hsuan Hsu
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Publication number: 20140314697Abstract: This invention discloses method for inhibiting inflammation and reducing melanophilin expression with glycine derivatives and the composition thereof. The mentioned glycine derivatives can not only efficiently inhibit skin inflammation, but also can present significant melanophilin expression reduction. This mentioned composition of this invention comprises the glycine derivatives, and shows melanophilin expression reduction and anti-inflammatory effect. The mentioned composition can be applied in topical cosmetic or pharmaceutical compositions as skin care preparations, or functional preparations.Type: ApplicationFiled: April 17, 2014Publication date: October 23, 2014Applicant: CORUM INC.Inventors: Ssu-Ching Wang, Pei-Hsuan Wu, Jun-Yi Yao, Nai-Hsuan Hsu
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Publication number: 20140155633Abstract: This invention discloses a composition for stabilizing ascorbic acid derivative and the application thereof. The mentioned composition comprises ascorbic acid derivative, buffer, phosphonic acid derivative and at least one alcohol. The yellowish and degradation of ascorbic acid derivative can be efficiently decreased by the mentioned composition. Moreover, the mentioned composition can be used in topical composition, such as toner, serum, lotion, cream.Type: ApplicationFiled: November 30, 2012Publication date: June 5, 2014Applicant: CORUM INC.Inventors: Lin-Chao Chen, Yu-Ling Shiu, Chia-Pei Lee, Chao-Yang Lee
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Publication number: 20140134121Abstract: The invention provides a method for inhibiting melanin formation composition by applying a glycine derivative, having a structure shown in the following general equation (I): wherein R1 represents a C1-C4 alkyl group; R2 represents a hydrogen atom or a methyl group; and n represents an integer of 1-6.Type: ApplicationFiled: January 21, 2014Publication date: May 15, 2014Applicant: CORUM INC.Inventors: Nai-Hsuan Hsu, Chiao-Yi Hsu, Ssu-Ching Wang, Ting-Wan Chen, Chu-Yi Pang
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Publication number: 20140113337Abstract: This invention discloses a process and composition for stimulating the production of hyaluronic acid. The mentioned process comprises reacting fibroblast cell with ascorbic acid derivatives. This invention provides a not only easy and un-expensive but also more efficient method for preparing safe hyaluronic acid by stimulatory in vitro.Type: ApplicationFiled: October 18, 2013Publication date: April 24, 2014Applicant: CORUM INC.Inventors: Wei-Yu Lin, Ssu-Ching Wang, Pei-Hsuan Wu, Siao-Huei Yi, Jun-Yi Yao
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Publication number: 20130195782Abstract: The invention provides a glycine derivative, having a structure shown in the following general equation (I): wherein R1 represents a C1˜C4 alkyl group; R2 represents a hydrogen atom or a methyl group; and n represents an integer of 1˜6.Type: ApplicationFiled: October 22, 2010Publication date: August 1, 2013Applicant: CORUM INC.Inventors: Nai-Hsuan Hsu, Chiao-Yi Hsu, Ssu-Ching Wang, Ting-Wan Chen, Chu-Yi Pang
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Publication number: 20110281943Abstract: The present invention discloses topical composition comprising ascorbic acid derivatives. The inventive topical composition that the ascorbic acid derivatives is homogeneously incorporated therein can make the ascorbic acid derivatives more widely used as active ingredient in skin topical formulation.Type: ApplicationFiled: April 29, 2011Publication date: November 17, 2011Applicant: CORUM INC.Inventors: Pei Min Lee, Leon Hides, Jen Han Lee, Man Li Peng, Lin Chiao Chen
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Patent number: 8053474Abstract: The present invention discloses compounds with a carboxyl acid group and an amide group which also containing the tertiary amino groups. The carboxyl acid group having a partial negative charge can attract the tertiary amino group with each other to form a quaternary ammonium salt structure, so that the compounds are easy to dissolve in water. Moreover, these compounds having a mushroom tyrosinase-inhibition effect and have the potential to use in the cosmetics for skin whitening.Type: GrantFiled: December 29, 2009Date of Patent: November 8, 2011Assignee: Corum Inc.Inventors: Wei-Chuan Tsai, Chen-Yin Chen, Ming-Yi Chiu, Yi-Fan Ling, Nai-Hsuan Hsu
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Patent number: 7935837Abstract: A process for synthesis of androstane 17-? carbothioic acid is provided. The process includes mixing an androstane 17-? carboxylic acid and a coupling reagent, and adding an alkanethioic acid to form an androstane 17-? carbothioic acid, wherein the androstane 17-? carbothioic acid has the formula (I): wherein R1 represents hydrogen or haloalkyl groups, R2 represents C1-8 linear alkyl groups, C1-8 branched alkyl groups, C1-6 unsaturated acyclic groups or aromatic groups, R3 represents hydrogen or hydroxyl, R4 represents hydrogen, bromine, chlorine or fluorine and R5 represents hydrogen, bromine, chlorine or fluorine. The process is a one-pot reaction.Type: GrantFiled: April 30, 2008Date of Patent: May 3, 2011Assignee: Corum Inc.Inventors: Nai-Hsuan Hsu, Chu-Yi Pang, Chien-Jen Wu, Chi-Jen Huang, Chia-Jung Hsu, Peimin Lee
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Publication number: 20110065954Abstract: The present invention discloses compounds with a carboxyl acid group and an amide group which also containing the tertiary amino groups. The carboxyl acid group having a partial negative charge can attract the tertiary amino group with each other to form a quaternary ammonium salt structure, so that the compounds are easy to dissolve in water. Moreover, these compounds having a mushroom tyrosinase-inhibition effect and have the potential to use in the cosmetics for skin whitening.Type: ApplicationFiled: December 29, 2009Publication date: March 17, 2011Applicant: CORUM INC.Inventors: Wei-Chuan Tsai, Chen-Yin Chen, Ming-Yi Chiu, Yi-Fan Ling, Nai-Hsuan Hsu
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Patent number: 7741496Abstract: The present invention discloses the ascorbic acid derivatives. The inventive molecules that combine with one or two hydrophilic headgroups connected by a hydrophobic spacer can increase skin penetration.Type: GrantFiled: September 3, 2009Date of Patent: June 22, 2010Assignee: Corum Inc.Inventors: Wei-Chuan Tsai, Chen-Yin Chen, Ming-Yi Chiu, Yi-Fan Ling, Nai-Hsuan Hsu
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Publication number: 20100056809Abstract: The present invention discloses the ascorbic acid derivatives. The inventive molecules that combine with one or two hydrophilic headgroups connected by a hydrophobic spacer can increase skin penetration.Type: ApplicationFiled: September 3, 2009Publication date: March 4, 2010Applicant: CORUM INC.Inventors: Wei-Chuan Tsai, Chen-Yin Chen, Ming-Yi Chiu, Yi-Fan Ling, Nai-Hsuan Hsu
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Publication number: 20090275767Abstract: A process for synthesis of androstane 17-? carbothioic acid is provided. The process includes mixing an androstane 17-? carboxylic acid and a coupling reagent, and adding an alkanethioic acid to form an androstane 17-? carbothioic acid, wherein the androstane 17-? carbothioic acid has the formula (I): wherein R1 represents hydrogen or haloalkyl groups, R2 represents C1-8 linear alkyl groups, C1-8 branched alkyl groups, C1-6 unsaturated acyclic groups or aromatic groups, R3 represents hydrogen or hydroxyl, R4 represents hydrogen, bromine, chlorine or fluorine and R5 represents hydrogen, bromine, chlorine or fluorine. The process is a one-pot reaction.Type: ApplicationFiled: April 30, 2008Publication date: November 5, 2009Applicant: CORUM INC.Inventors: Nai-Hsuan Hsu, Chu-Yi Pang, Chien-Jen Wu, Chi-Jen Huang, Chia-Jung Hsu, Peimin Lee