Abstract: The present invention relates to a method for manufacturing a prefilled single-dose syringe.It comprises a station (12) for supplying the ampoules (2), a station (13) for pregassing the ampoules (2), a station (14) for filling-gassing the ampoules (2), a station (15) for supplying the injector bodies (3), equipped with their needle-holder covering cap (4), a station (16) for assembling the ampoules (2) and the injector bodies (3), a station (19) for final control of the syringe (1), a station (22) for release of the syringes accepted by the final control station, a station (20) for quantitative control of gassing of the syringes, a station (21) for qualitative control of gassing of the syringes.