Abstract: The practical stethoscope cover of this invention in its most essential elements, comprises any form of material which acts as an effective, inexpensive and acoustically transmissive barrier means for easy application and removal from the head, or heads, of a stethoscope. The barrier means should be non-transmissive for dirt, organisms, oils, fluids and the like, all of which may carry pathogenic components. Significantly, embodiments of the stethoscope cover of this invention are easily applied by a physician, nurse or other medical practitioner to the head of a single-headed stethoscope or a double-headed stethoscope, typically in a quick, simple, easy single-handed operation. The barrier means comprising the stethoscope cover comprises folds, gathers or crimping at the marginal edges or medial portions thereof, providing flexibility, extensibility or elasticity to the cover, thus facilitating easy application and removal of the stethoscope cover from the head of the stethoscope.