Patents Assigned to Crescendo AS
  • Therapeutic molecules that bind to LAG3 and PD1
    Patent number: 11951172
    Abstract: The invention relates to LAG-3 binding agents, in particular variable heavy chain (VH) sdAbs and bispecific agents that target both LAG-3 and PD-1, and the use of such binding agents in the treatment, prevention and detection of disease.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: April 9, 2024
    Assignee: CRESCENDO BIOLOGICS LIMITED
    Inventors: Carolyn Edwards, Angelica Sette, Isabelle Osuch, Yumin Teng, James Legg, David Escors Murugarren
  • Chimeric antigen receptor with single domain antibody
    Patent number: 11866510
    Abstract: The invention relates to chimeric antigen receptors (CAR) that comprise one or more single human variable domain antibody and cells that express such CAR. In particular, the invention relates to CARs that include multiple single human variable domain antibodies. In a particular embodiment, the one or more single human variable domain antibody binds to prostate membrane antigen.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: January 9, 2024
    Assignee: CRESCENDO BIOLOGICS LIMITED
    Inventors: Brian McGuinness, Colette Johnston
  • Single domain antibodies to programmed cell death (PD-1)
    Patent number: 11814429
    Abstract: The invention relates to PD-1 binding agents that do not block the interaction of PD-1 with its ligands, and the use of such binding agents in the treatment, prevention and detection of disease.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: November 14, 2023
    Assignee: CRESCENDO BIOLOGICS LIMITED
    Inventors: Bryan Edwards, Carolyn Edwards, James Legg, Martyna Lewandowska, Daniela Sydoruk, Colette Johnston, Christine Rossant, Yumin Teng
  • Therapeutic molecules
    Patent number: 11746158
    Abstract: The invention relates to binding molecules that bind specifically to prostate specific membrane antigen (PSMA), in particular, single human variable heavy chain domain antibodies and related methods for treatment of cancer.
    Type: Grant
    Filed: October 22, 2021
    Date of Patent: September 5, 2023
    Assignee: Crescendo Biologics Limited
    Inventors: Brian McGuinness, Isabelle Osuch, Chris Rossant, Mike Romanos, Nikki Royle, Thomas Sandal, Lorraine Thompson, Michele Writer
  • IL-17A binding proteins
    Patent number: 11667705
    Abstract: Binding molecules to IL-17A. The binding molecules are useful in the treatment of disorders, for example psoriasis.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: June 6, 2023
    Assignee: Crescendo Biologics Limited
    Inventors: Bryan Edwards, Ulla Lashmar, Brian McGuinness, Mike Romanos, Thomas Sandal, Yumin Teng
  • TRANSGENIC MICE
    Publication number: 20230133028
    Abstract: The invention relates to nucleic acid constructs for expression in mice for the reproduction of heavy chain only antibodies and VH domains, transgenic mice, related methods and uses.
    Type: Application
    Filed: October 19, 2022
    Publication date: May 4, 2023
    Applicant: Crescendo Biologics Limited
    Inventors: Yumin Teng, Joyce Young, Brian McGuinness, Mike Romanos, Marianne Brueggemann
  • Single domain antibodies to programmed cell death protein 1 (PD-1)
    Patent number: 11591398
    Abstract: The invention relates to PD-1 binding agents that block the interaction of PD-1 with its ligands, and the use of such binding agents in the treatment, prevention and detection of disease.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: February 28, 2023
    Assignee: CRESCENDO BIOLOGICS LIMITED
    Inventors: Phil Hayes, James Legg, Martyna Lewandowska, Colette Johnston, Brian McGuinness, Mike Romanos, Christine Rossant, Yumin Teng
  • Transgenic mice
    Patent number: 11547099
    Abstract: The invention relates to nucleic acid constructs for expression in mice for the production of heavy chain only antibodies and VH domains, transgenic mice, related methods and uses.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: January 10, 2023
    Assignee: Crescendo Biologies Limited
    Inventors: Yumin Teng, Joyce Young, Brian McGuinness, Mike Romanos, Marianne Brueggemann
  • Therapeutic molecules binding PSMA
    Patent number: 11401342
    Abstract: The invention relates to improved binding molecules that bind specifically to prostate specific membrane antigen (PSMA), in particular, single human variable heavy chain domain antibodies and related methods for treatment of cancer.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: August 2, 2022
    Assignee: CRESCENDO BIOLOGICS LIMITED
    Inventors: Nikki Royle, Steve Vance, Viviane Zelenay
  • Single-domain antibodies to programmed cell death 1 protein (PD-1), encoding nucleic acids and methods of using same
    Patent number: 11312771
    Abstract: The invention relates to multifunctional PD-1 binding agents and the use of such binding agents in the treatment, prevention and detection of disease.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: April 26, 2022
    Assignee: CRESCENDO BIOLOGICS LIMITED
    Inventors: Carolyn Edwards, James Legg, Martyna Lewandowska, Colette Johnston, Christine Rossant, Yumin Teng
  • Therapeutic molecules
    Patent number: 11236174
    Abstract: The invention relates to binding molecules that bind specifically to prostate specific membrane antigen (PSMA), in particular, single human variable heavy chain domain antibodies and related methods for treatment of cancer.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: February 1, 2022
    Assignee: CRESCENDO BIOLOGICS LIMITED
    Inventors: Brian McGuinness, Isabelle Osuch, Chris Rossant, Mike Romanos, Nikki Royle, Thomas Sandal, Lorraine Thompson, Michele Writer
  • BIOMARKERS AND METHODS FOR ASSESSING RESPONSE TO INFLAMMATORY DISEASE THERAPY WITHDRAWAL
    Publication number: 20210208139
    Abstract: Provided herein are methods for assessing response to inflammatory disease therapy. The methods include placing a subject on a therapeutic regimen and subsequently performing an immunoassay to generate a score based on quantitative data for expression of biomarkers relating to inflammatory biomarkers. The methods further include recommending that the subject either remains on the therapeutic regimen, or is removed from the therapeutic regimen, based on the score.
    Type: Application
    Filed: March 15, 2021
    Publication date: July 8, 2021
    Applicant: CRESCENDO BIOSCIENCE
    Inventor: Eric Sasso
  • BIOMARKERS AND METHODS FOR ASSESSING MYOCARDIAL INFARCTION AND SERIOUS INFECTION RISK IN RHEUMATOID ARTHRITIS PATIENTS
    Publication number: 20210199671
    Abstract: Provided herein are methods for assessing risk of infection or cardiovascular disease (CVD) in a subject with an inflammatory disease, e.g., rheumatoid arthritis. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers with or without additional clinical variables to assess infection and CVD risk. Also provided are uses of inflammatory biomarkers for guiding treatment decisions.
    Type: Application
    Filed: March 15, 2021
    Publication date: July 1, 2021
    Applicants: CRESCENDO BIOSCIENCE, INC., UAB RESEARCH FOUNDATION
    Inventors: Kerri FORD, Jeffrey R. CURTIS
  • Methods for assessing response to inflammatory disease therapy withdrawal
    Patent number: 10983120
    Abstract: Provided herein are methods for assessing response to inflammatory disease therapy. The methods include placing a subject on a therapeutic regimen and subsequently performing an immunoassay to generate a score based on quantitative data for expression of biomarkers relating to inflammatory biomarkers. The methods further include recommending that the subject either remains on the therapeutic regimen, or is removed from the therapeutic regimen, based on the score.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: April 20, 2021
    Assignee: Crescendo Bioscience
    Inventor: Eric Sasso
  • Molecules that bind prostate specific membrane antigen (PSMA)
    Patent number: 10975161
    Abstract: The disclosure relates to binding molecules that bind specifically to prostate specific membrane antigen (PSMA), in particular, single human variable heavy chain domain antibodies and related methods for treatment of cancer.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: April 13, 2021
    Assignee: CRESCENDO BIOLOGICS LIMITED
    Inventors: Eleanora Balloi, Normann Goodwin, Brian McGuinness, Chris Rossant, Thomas Sandal, Lorraine Thompson
  • Biomarkers and methods for assessing myocardial infarction and serious infection risk in rheumatoid arthritis patients
    Patent number: 10962552
    Abstract: Provided herein are methods for assessing risk of infection or cardiovascular disease (CVD) in a subject with an inflammatory disease, e.g., rheumatoid arthritis. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers with or without additional clinical variables to assess infection and CVD risk. Also provided are uses of inflammatory biomarkers for guiding treatment decisions.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: March 30, 2021
    Assignees: CRESCENDO BIOSCIENCE, INC., UAB RESEARCH FOUNDATION
    Inventors: Kerri Ford, Jeffrey R. Curtis
  • Composition for treatment of disorders
    Patent number: 10947308
    Abstract: The invention relates to stable and non-aggregating compositions comprising an IL-17A binding molecule, in particular a single domain antibody. Such compositions are useful for topical administration in the treatment of disease, for example skin disease or asthma.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: March 16, 2021
    Assignee: Crescendo Biologics Limited
    Inventors: Karen Bannister, Ulla Lashmar, Daniel Pettit, Thomas Sandal
  • BIOMARKERS AND METHODS FOR MEASURING AND MONITORING JUVENILE IDIOPATHIC ARTHRITIS ACTIVITY
    Publication number: 20200300853
    Abstract: Biomarkers useful for assessing inflammatory disease or flare activity, in particular in juvenile idiopathic arthritis, are provided, along with kits for measuring expression of the biomarkers. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.
    Type: Application
    Filed: June 9, 2020
    Publication date: September 24, 2020
    Applicant: CRESCENDO BIOSCIENCE, INC.
    Inventors: Scott Eastman, Eric Sasso
  • BIOMARKERS AND METHODS FOR ASSESSING MYOCARDIAL INFARCTION AND SERIOUS INFECTION RISK IN RHEUMATOID ARTHRITIS PATIENTS
    Publication number: 20200292559
    Abstract: Provided herein are methods for assessing risk of infection or cardiovascular disease (CVD) in a subject with an inflammatory disease, e.g., rheumatoid arthritis. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers with or without additional clinical variables to assess infection and CVD risk. Also provided are uses of inflammatory biomarkers for guiding treatment decisions.
    Type: Application
    Filed: March 10, 2020
    Publication date: September 17, 2020
    Applicants: CRESCENDO BIOSCIENCE, INC., UAB RESEARCH FOUNDATION
    Inventors: Kerri FORD, Jeffrey R. CURTIS
  • Biomarkers and methods for measuring and monitoring juvenile idiopathic arthritis activity
    Patent number: 10718765
    Abstract: Biomarkers useful for assessing inflammatory disease or flare activity, in particular in juvenile idiopathic arthritis, are provided, along with kits for measuring expression of the biomarkers. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: July 21, 2020
    Assignee: CRESCENDO BIOSCIENCE, INC.
    Inventors: Scott Eastman, Eric Sasso