Patents Assigned to Cumberland Pharmaceuticals Inc.
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Patent number: 9072661Abstract: The present invention provides a pharmaceutical composition comprising an aqueous solution of an ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition. The invention further provides a method of treating a condition chosen from pain, inflammation, fever, and/or patent ductus arteriosis, comprising administering to a patient in need thereof an effective amount of an aqueous solution a ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition, as well as a method for manufacturing the composition.Type: GrantFiled: March 16, 2012Date of Patent: July 7, 2015Assignee: Cumberland Pharmaceuticals Inc.Inventors: Leo Pavliv, Andrew Vila
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Patent number: 8952065Abstract: This invention relates to novel acetylcysteine compositions in solution, comprising acetylcysteine and which are substantially free of metal chelating agents, such as EDTA. Further, this invention relates to methods of making and using the acetylcysteine compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time maintaining the stability of the pharmaceutical formulation. The compositions and methods of this invention are useful in the treatment of acetaminophen overdose, acute liver failure, various cancers, methacrylonitrile poisoning, reperfusion injury during cardio bypass surgery, and radiocontrast-induced nephropathy, and can also be used as a mucolytic agent.Type: GrantFiled: January 13, 2014Date of Patent: February 10, 2015Assignee: Cumberland Pharmaceuticals, Inc.Inventor: Leo Pavliv
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Patent number: 8933115Abstract: The present invention is directed to statin formulations having improved solubility and/or stability and methods for the same.Type: GrantFiled: January 22, 2013Date of Patent: January 13, 2015Assignee: Cumberland Pharmaceuticals Inc.Inventors: Leo Pavliv, Andrew Vila
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Patent number: 8871810Abstract: Methods of treating at least one condition chosen from pain, inflammation, and fever in a critically ill patient in need thereof, comprising administering to the critically ill patient an intravenous pharmaceutical composition comprising ibuprofen using a first dosage regimen, wherein the first dosage regimen produces a first pharmacokinetic profile in critically ill patients that is about equivalent to a second pharmacokinetic profile produced by administration of the intravenous pharmaceutical composition using a second dosage regimen of ibuprofen to non-critically ill patients, wherein the at least one condition of the critically ill patient is thereby treated.Type: GrantFiled: December 23, 2009Date of Patent: October 28, 2014Assignee: Cumberland Pharmaceuticals Inc.Inventors: Leo Pavliv, Amy Dix Rock
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Publication number: 20140235720Abstract: Methods of treating a patient in need thereof, comprising administering to the critically ill patient an intravenous pharmaceutical composition comprising ibuprofen in an amount effective to treat at least one condition in the patient chosen from pain, inflammation, and fever and to provide a clinically relevant effect on mean arterial pressure of the patients during the dosage interval comprising no increase or no statistically significant increase in mean arterial pressure.Type: ApplicationFiled: April 29, 2014Publication date: August 21, 2014Applicant: Cumberland Pharmaceuticals Inc.Inventors: Leo Pavliv, Amy Dix Rock
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Publication number: 20140206765Abstract: A pharmaceutical composition and method for providing a reduction in side effects for human patients in need of therapy comprising the administration of a pharmaceutical composition comprising acetylcysteine is disclosed.Type: ApplicationFiled: March 25, 2014Publication date: July 24, 2014Applicant: Cumberland Pharmaceuticals, Inc.Inventors: Leo Pavliv, Amy Rock
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Patent number: 8735452Abstract: Methods of treating a patient in need thereof, comprising administering to the critically ill patient an intravenous pharmaceutical composition comprising ibuprofen in an amount effective to treat at least one condition in the patient chosen from pain, inflammation, and fever and to provide a clinically relevant effect on mean arterial pressure of the patients during the dosage interval comprising no increase or no statistically significant increase in mean arterial pressure.Type: GrantFiled: February 3, 2010Date of Patent: May 27, 2014Assignee: Cumberland Pharmaceuticals Inc.Inventors: Leo Pavliv, Amy Dix Rock
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Patent number: 8722738Abstract: A pharmaceutical composition and method for providing a reduction in side effects for human patients in need of therapy comprising the administration of a pharmaceutical composition comprising acetylcysteine is disclosed.Type: GrantFiled: July 21, 2011Date of Patent: May 13, 2014Assignee: Cumberland Pharmaceuticals, Inc.Inventors: Leo Pavliv, Amy Rock
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Publication number: 20140128470Abstract: This invention relates to novel acetylcysteine compositions in solution, comprising acetylcysteine and which are substantially free of metal chelating agents, such as EDTA. Further, this invention relates to methods of making and using the acetylcysteine compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time maintaining the stability of the pharmaceutical formulation. The compositions and methods of this invention are useful in the treatment of acetaminophen overdose, acute liver failure, various cancers, methacrylonitrile poisoning, reperfusion injury during cardio bypass surgery, and radiocontrast-induced nephropathy, and can also be used as a mucolytic agent.Type: ApplicationFiled: January 13, 2014Publication date: May 8, 2014Applicant: Cumberland Pharmaceuticals, Inc.Inventor: Leo Pavliv
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Patent number: 8653061Abstract: This invention relates to novel acetylcysteine compositions in solution, comprising acetylcysteine and which are substantially free of metal chelating agents, such as EDTA. Further, this invention relates to methods of making and using the acetylcysteine compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time maintaining the stability of the pharmaceutical formulation. The compositions and methods of this invention are useful in the treatment of acetaminophen overdose, acute liver failure, various cancers, methacrylonitrile poisoning, reperfusion injury during cardio bypass surgery, and radiocontrast-induced nephropathy, and can also be used as a mucolytic agent.Type: GrantFiled: February 1, 2013Date of Patent: February 18, 2014Assignee: Cumberland Pharmaceuticals, Inc.Inventor: Leo Pavliv
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Publication number: 20130245120Abstract: The present invention provides a pharmaceutical composition comprising an aqueous solution of an ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition. The invention further provides a method of treating a condition chosen from pain, inflammation, fever, and/or patent ductus arteriosis, comprising administering to a patient in need thereof an effective amount of an aqueous solution a ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition, as well as a method for manufacturing the composition.Type: ApplicationFiled: March 16, 2012Publication date: September 19, 2013Applicant: Cumberland Pharmaceuticals Inc.Inventors: Leo Pavliv, Andrew Vila
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Publication number: 20130245591Abstract: The present invention provides a pharmaceutical composition comprising an aqueous solution of an ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition. The invention further provides a method of treating a condition chosen from pain, inflammation, fever, and/or patent ductus arteriosis, comprising administering to a patient in need thereof an effective amount of an aqueous solution a ibuprofen solubilizing agent and ibuprofen, the ibuprofen solubilizing agent being in an effective amount such that the ibuprofen in the solution remains soluble at concentrations from 100 mg/mL to 5 mg/mL without undergoing a phase transition, as well as a method for manufacturing the composition.Type: ApplicationFiled: March 16, 2012Publication date: September 19, 2013Applicant: Cumberland Pharmaceuticals Inc.Inventors: Leo Pavliv, Andrew Vila
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Publication number: 20130237603Abstract: A pharmaceutical composition and method for providing a reduction in side effects for human patients in need of therapy comprising the administration of a pharmaceutical composition comprising acetylcysteine is disclosed.Type: ApplicationFiled: March 12, 2013Publication date: September 12, 2013Applicant: CUMBERLAND PHARMACEUTICALS, INC.Inventors: Leo Pavliv, Amy Rock
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Publication number: 20130190403Abstract: A method for treating human patients who require hospitalization for a trauma injury wherein the patients are intravenously administered a first dose of a therapeutically effective dose of ibuprofen intravenously as soon as possible after hospitalization is disclosed. The patients are further treated with intravenous ibuprofen at suitable dosing intervals to the human patient until (a) the patient no longer requires intravenous dosing of ibuprofen.Type: ApplicationFiled: January 23, 2012Publication date: July 25, 2013Applicant: Cumberland Pharmaceuticals Inc.Inventors: Leo Pavliv, Amy Dix Rock
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Publication number: 20130165516Abstract: This invention relates to novel acetylcysteine compositions in solution, comprising acetylcysteine and which are substantially free of metal chelating agents, such as EDTA. Further, this invention relates to methods of making and using the acetylcysteine compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time maintaining the stability of the pharmaceutical formulation. The compositions and methods of this invention are useful in the treatment of acetaminophen overdose, acute liver failure, various cancers, methacrylonitrile poisoning, reperfusion injury during cardio bypass surgery, and radiocontrast-induced nephropathy, and can also be used as a mucolytic agent.Type: ApplicationFiled: February 1, 2013Publication date: June 27, 2013Applicant: CUMBERLAND PHARMACEUTICALS, INC.Inventor: Cumberland Pharmaceuticals, Inc.
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Publication number: 20130137745Abstract: The present invention is directed to statin formulations having improved solubility and/or stability and methods for the same.Type: ApplicationFiled: January 22, 2013Publication date: May 30, 2013Applicant: Cumberland Pharmaceuticals Inc.Inventor: Cumberland Pharmaceuticals Inc.
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Patent number: 8399445Abstract: This invention relates to novel acetylcysteine compositions in solution, comprising acetylcysteine and which are substantially free of metal chelating agents, such as EDTA. Further, this invention relates to methods of making and using the acetylcysteine compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time maintaining the stability of the pharmaceutical formulation. The compositions and methods of this invention are useful in the treatment of acetaminophen overdose, acute liver failure, various cancers, methacrylonitrile poisoning, reperfusion injury during cardio bypass surgery, and radiocontrast-induced nephropathy, and can also be used as a mucolytic agent.Type: GrantFiled: February 27, 2012Date of Patent: March 19, 2013Assignee: Cumberland Pharmaceuticals, Inc.Inventor: Leo Pavliv
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Patent number: 8148356Abstract: This invention relates to novel acetylcysteine compositions in solution, comprising acetylcysteine and which are substantially free of metal chelating agents, such as EDTA. Further, this invention relates to methods of making and using the acetylcysteine compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time maintaining the stability of the pharmaceutical formulation. The compositions and methods of this invention are useful in the treatment of acetaminophen overdose, acute liver failure, various cancers, methacrylonitrile poisoning, reperfusion injury during cardio bypass surgery, and radiocontrast-induced nephropathy, and can also be used as a mucolytic agent.Type: GrantFiled: August 24, 2005Date of Patent: April 3, 2012Assignee: Cumberland Pharmaceuticals, Inc.Inventor: Leo Pavliv
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Publication number: 20120022161Abstract: A pharmaceutical composition and method for providing a reduction in side effects for human patients in need of therapy comprising the administration of a pharmaceutical composition comprising acetylcysteine is disclosed.Type: ApplicationFiled: July 21, 2011Publication date: January 26, 2012Applicant: Cumberland Pharmaceuticals, Inc.Inventor: Leo PAVLIV
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Publication number: 20110257240Abstract: The present invention is directed to statin formulations having improved solubility and/or stability and methods for the same.Type: ApplicationFiled: April 16, 2010Publication date: October 20, 2011Applicant: Cumberland Pharmaceuticals Inc.Inventors: Leo Pavliv, Andrew Vila