Abstract: A Rifaximin polymorphic mixture of ?/? form in a relative ratio of 85/15±3 and a process for its preparation. The polymorphic mixture of Rifaximin is for use as a medicament, in particular in the treatment of traveler's diarrhea and hepatic encephalopathy. A pharmaceutical composition comprises the polymorphic mixture of Rifaximin as active ingredient, in particular, a solid formulation, more in particular, a film coated tablet. A polymorphic form of crude wet rifaximin and of purified wet rifaximin their use are used as intermediates in a process for the preparation of Rifaximin polymorphic mixture of ?/? form in a relative ratio of 85/15±3.
Type:
Grant
Filed:
January 26, 2021
Date of Patent:
August 29, 2023
Assignee:
CURIA IP HOLDINGS, LLC
Inventors:
Paride Grisenti, Maria Argese, Daniele Pengo, Maria Donata Grilli, Emanuela Fumagalli, Giuseppe Motta
Abstract: The invention provides novel anti-BTLA antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.
Type:
Grant
Filed:
March 31, 2020
Date of Patent:
July 12, 2022
Assignees:
Curia IP Holdings, LLC, TRIANNI, Inc.
Inventors:
Brian A. Zabel, John A. Lippincott, Yayue Zheng, Megha Vaman Rao, Miao Tan, David P. Meininger