Abstract: The present invention provides a computer device and a computer-implemented method to quantify the extent of functional coronary artery disease. In addition, the invention provides a computer device for determining the functional pattern of coronary disease in a mammal. It is shown that a mismatch in the extent of CAD between anatomical and physiological evaluations is predictable for an improvement in epicardial conductance with percutaneous revascularization. More particularly the invention provides methods to select a mammal suffering from coronary disease to benefit from a percutaneous coronary intervention.