Patents Assigned to Cygnus, Inc.
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Patent number: 6615078Abstract: This invention relates to methods for reducing the presence of a compound in an ionically conductive material, e.g., for use in iontophoretic devices, wherein the presence of the compound interferes with detecting a selected analyte. Removal of the compound can typically take place either during or after the manufacture of the ionically conductive material or an assembly comprising this material. Also disclosed are methods for generating selectively permeable barriers on the reactive faces of electrodes. Further, this invention relates to hydrogels comprising one or more biocides, as well as assemblies containing such hydrogels.Type: GrantFiled: April 21, 2000Date of Patent: September 2, 2003Assignee: Cygnus, Inc.Inventors: Kim K. Burson, Michelle Van Wyhe, Jeffrey Pudlo, Michael Reidy, Pravin Soni, Christopher Uhegbu, Prema Vijayakumar
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Publication number: 20030155557Abstract: The invention is directed to conductive polymer compositions, catalytic ink compositions (e.g., for use in screen-printing), electrodes produced by deposition of an ink composition, methods of making, and methods of using thereof. An exemplary ink material comprises platinum black and/or platinum-on-carbon as the catalyst, graphite as a conducting material, a polymer binding material, and an organic solvent. The polymer binding material is typically a copolymer of hydrophilic and hydrophobic monomers. The conductive polymer compositions of the present invention can be used, for example, to make electrochemical sensors. Such sensors can be used in a variety of analyte monitoring devices to monitor analyte amount or concentrations in subjects, for example, glucose monitoring devices to monitor glucose levels in subjects with diabetes.Type: ApplicationFiled: December 19, 2002Publication date: August 21, 2003Applicant: Cygnus, Inc.Inventor: Michael J. Tierney
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Publication number: 20030153820Abstract: A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.Type: ApplicationFiled: February 12, 2003Publication date: August 14, 2003Applicant: Cygnus, Inc.Inventors: Bret Berner, Timothy C. Dunn, Kathleen C. Farinas, Michael D. Garrison, Ronald T. Kurnik, Matthew J. Lesho, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
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Publication number: 20030153821Abstract: A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.Type: ApplicationFiled: March 7, 2003Publication date: August 14, 2003Applicant: Cygnus, Inc.Inventors: Bret Berner, Timothy C. Dunn, Kathleen C. Farinas, Michael D. Garrison, Ronald T. Kurnik, Matthew J. Lesho, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
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Publication number: 20030144581Abstract: Devices and methods are provided for frequently measuring the concentration of an analyte present in a biological system. A monitoring system having at least two components is employed in order to allow separation of data collection from data processing and display. Such separation allows greater flexibility and convenience for the user.Type: ApplicationFiled: January 29, 2003Publication date: July 31, 2003Applicant: Cygnus, Inc.Inventors: Thomas E. Conn, Russell Ford, Russell O. Potts, Pravin L. Soni, Janet A. Tamada, Michael J. Tierney
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Patent number: 6595919Abstract: A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.Type: GrantFiled: February 27, 2001Date of Patent: July 22, 2003Assignee: Cygnus, Inc.Inventors: Bret Berner, Timothy C. Dunn, Kathleen C. Farinas, Michael D. Garrison, Ronald T. Kurnik, Matthew J. Lesho, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
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Publication number: 20030135100Abstract: An automated system for continual transdermal extraction of analytes present in a biological system is provided. The system can be used for detecting and/or measuring the concentration of the analyte using an electrochemical biosensor detection means. The system optionally uses reverse iontophoresis to carry out the continual transdermal extraction of the analytes.Type: ApplicationFiled: January 29, 2003Publication date: July 17, 2003Applicant: Cygnus, Inc.Inventors: Lynn Kim, Norman A. Parris, Russell O. Potts, Janet Tamada, Michael J. Tierney, Bret Berner
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Patent number: 6594514Abstract: Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.Type: GrantFiled: December 20, 2001Date of Patent: July 15, 2003Assignee: Cygnus, Inc.Inventors: Bret Berner, Chia-Ming Chiang, Michael D. Garrison, Janan Jona, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
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Publication number: 20030120138Abstract: A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g.Type: ApplicationFiled: December 20, 2002Publication date: June 26, 2003Applicant: Cygnus, Inc.Inventors: Ronald T. Kurnik, Janet Tamada, Michael Tierney
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Patent number: 6561978Abstract: Devices and methods are provided for frequently measuring the concentration of an analyte present in a biological system. A monitoring system having at least two components is employed in order to allow separation of data collection from data processing and display. Such separation allows greater flexibility and convenience for the user.Type: GrantFiled: February 11, 2000Date of Patent: May 13, 2003Assignee: Cygnus, Inc.Inventors: Thomas E. Conn, Russell Ford, Russell O. Potts, Pravin L. Soni, Janet A. Tamada, Michael J. Tierney
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Patent number: 6553244Abstract: The present invention relates to a device for augmenting an alarm signal generated by an analyte monitoring device, e.g., the GlucoWatch® (Cygnus, Inc., Redwood City, Calif.) biographer glucose monitoring device, for improving the alarm signal's effectiveness in alerting the user, and/or for communicating the signal to a person or person(s) other than the user, or to a trained assistance animal.Type: GrantFiled: August 10, 2001Date of Patent: April 22, 2003Assignee: Cygnus, Inc.Inventors: Matthew J. Lesho, Samuel A. Morley, Jr.
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Patent number: 6546269Abstract: A method and device are provided for measuring the concentration of target chemical analytes present in a biological system, and then predicting a future or past concentration of an analyte using a series of such measurements. One important application of the invention involves predicting future or past blood glucose concentrations using a series of measured blood glucose values.Type: GrantFiled: January 5, 2001Date of Patent: April 8, 2003Assignee: Cygnus, Inc.Inventor: Ronald T. Kurnik
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Patent number: 6529755Abstract: A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g.Type: GrantFiled: December 6, 2001Date of Patent: March 4, 2003Assignee: Cygnus, Inc.Inventors: Ronald T. Kurnik, Janet Tamada, Michael Tierney
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Patent number: 6438414Abstract: The invention relates generally to consumable components of a device used for continually or continuously measuring the concentration of target chemical analytes present in a biological system. More particularly, the invention relates to collection assemblies, laminate structures, and autosensor assemblies, which are used in connection with a transdermal sampling device. In one aspect, the invention includes autosensor assemblies which include laminate structures, electrode assemblies, and support trays. One important application of the invention involves an autosensor assembly for use in a blood glucose monitoring device.Type: GrantFiled: November 30, 2001Date of Patent: August 20, 2002Assignee: Cygnus, Inc.Inventors: Thomas E. Conn, Russell Ford, Pravin L. Soni, Michael J. Tierney, Prema Vijayakumar
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Publication number: 20020091312Abstract: Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.Type: ApplicationFiled: December 20, 2001Publication date: July 11, 2002Applicant: Cygnus, Inc.Inventors: Bret Berner, Chia-Ming Chiang, Michael D. Garrison, Janan Jona, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
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Patent number: 6398562Abstract: Devices and methods are described for improving the contact of a conductive material, for example, a hydrogel, with a sensor, for example an electrode, by means of using mechanical force to apply the conductive material to the sensor before use of the conductive material and sensor in a sampling device. The device and methods of the present invention improve the sensor response characteristics in transdermal sampling devices placed in operative contact with a skin or mucosal surface of a biological system to obtain a chemical signal associated with an analyte of interest.Type: GrantFiled: September 17, 1999Date of Patent: June 4, 2002Assignee: Cygnus, Inc.Inventors: Michael J. Butler, Thomas E. Conn, David M. Liu, Norman A. Parris, Michael Reidy, Pravin L. Soni
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Publication number: 20020062073Abstract: A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g.Type: ApplicationFiled: December 6, 2001Publication date: May 23, 2002Applicant: Cygnus, Inc.Inventors: Ronald T. Kurnik, Janet Tamada, Michael Tierney
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Patent number: 6393318Abstract: The invention relates generally to consumable components of a device used for continually or continuously measuring the concentration of target chemical analytes present in a biological system. More particularly, the invention relates to collection assemblies, laminate structures, and autosensor assemblies, which are used in connection with a transdermal sampling device. In one aspect, the invention includes autosensor assemblies which include laminate structures, electrode assemblies, and support trays. One important application of the invention involves an autosensor assembly for use in a blood glucose monitoring device.Type: GrantFiled: May 11, 1999Date of Patent: May 21, 2002Assignee: Cygnus, Inc.Inventors: Thomas E. Conn, Russell Ford, Pravin L. Soni, Michael J. Tierney, Prema Vijayakumar
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Patent number: 6391643Abstract: An automated system for continual transdermal extraction of analytes present in a biological system is described. The system optionally uses reverse iontophoresis to carry out the continual transdermal extraction of the analytes. The present invention describes quality control test kits, and methods of use thereof, for testing the ability of the system to provide reliable, effective, and accurate determination of analyte concentration.Type: GrantFiled: October 27, 1999Date of Patent: May 21, 2002Assignee: Cygnus, Inc.Inventors: Qiang Chen, David M. Liu, Brian S. Kersten, Christine M. Wu
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Publication number: 20020053637Abstract: The invention relates generally to consumable components of a device used for continually or continuously measuring the concentration of target chemical analytes present in a biological system. More particularly, the invention relates to collection assemblies, laminate structures, and autosensor assemblies, which are used in connection with a transdermal sampling device. In one aspect, the invention includes autosensor assemblies which include laminate structures, electrode assemblies, and support trays. One important application of the invention involves an autosensor assembly for use in a blood glucose monitoring device.Type: ApplicationFiled: November 30, 2001Publication date: May 9, 2002Applicant: Cygnus, Inc.Inventors: Thomas E. Conn, Russell Ford, Pravin L. Soni, Michael J. Tierney, Prema Vijayakumar