Abstract: Kits, devices, systems and related methods for obtaining a nasopharyngeal sample utilize a rinsing fluid supply component and a collecting component, which may be used as separate modules or integrated with a housing to form a handheld unit that may be operated with a single hand. The dispensing component may include a flexible reservoir pump containing a supply of rinsing fluid, and a first nostril interface adapted to engage a first nostril of a patient and guide a stream of rinsing fluid into the patient's nasal cavity. The collecting component may include a collection container and a second nostril interface adapted to engage a second nostril of a patient and collect effluent. An absorbent shield may be arranged on the integrated unit to absorb stray fluid.