Patents Assigned to Cytogel Pharma, LLC
  • Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof
    Patent number: 11603385
    Abstract: The subject invention provides compositions and methods for alleviating pain. Specifically, the subject invention provides pharmaceutical formulations of peptides, and/or their salts, having advantageous ?-opioid receptor binding activity.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: March 14, 2023
    Assignee: CYTOGEL PHARMA, LLC
    Inventors: Theodore E. Maione, Constantine Basil Maglaris
  • Materials and methods for treatment of inflammation
    Patent number: 11324798
    Abstract: The subject invention pertains to peptides and salts thereof that are useful as anti-inflammatory agents and to compositions containing such peptides and salts as active ingredients. Specifically exemplified herein are endomorphin-1 peptide (EM-1), analogs and salts thereof, and uses for modulation of calcitonin gene-related peptide (CGRP) production and/or substance P (SP) and for treatment of inflammation, particularly neurogenic inflammation.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: May 10, 2022
    Assignee: CYTOGEL PHARMA, LLC
    Inventors: Theodore E. Maione, Constantine Basil Maglaris
  • Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof
    Patent number: 10975121
    Abstract: The subject invention provides compositions and methods for alleviating pain. Specifically, the subject invention provides pharmaceutical formulations of peptides, and/or their salts, having advantageous ?-opioid receptor binding activity.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: April 13, 2021
    Assignee: CYTOGEL PHARMA, LLC
    Inventors: Theodore E. Maione, Constantine Basil Maglaris
  • Materials and methods for treatment of inflammation
    Patent number: 10441625
    Abstract: The subject invention pertains to peptides and salts thereof that are useful as anti-inflammatory agents and to compositions containing such peptides and salts as active ingredients. Specifically exemplified herein are endomorphin-1 peptide (EM-1), analogs and salts thereof, and uses for modulation of calcitonin gene-related peptide (CGRP) production and/or substance P (SP) and for treatment of inflammation, particularly neurogenic inflammation.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: October 15, 2019
    Assignee: CYTOGEL PHARMA, LLC
    Inventors: Theodore E. Maione, Constantine Basil Maglaris
  • Advantageous salts of ?-opiate receptor peptides
    Patent number: 8940704
    Abstract: The subject invention provides advantageous new salts of mu-opiate receptor peptides. These salts have been found to have excellent properties in terms of their crystal structure, stability, solubility, lack of impurities and/or the ability to be produced, with these advantageous properties, in amounts sufficient for the production of therapeutic compositions.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: January 27, 2015
    Assignee: Cytogel Pharma, LLC
    Inventor: Theodore E Maione
  • ADVANTAGEOUS SALTS OF MU-OPIATE RECEPTOR PEPTIDES
    Publication number: 20140142050
    Abstract: The subject invention provides advantageous new salts of mu-opiate receptor peptides. These salts have been found to have excellent properties in terms of their crystal structure, stability, solubility, lack of impurities and/or the ability to be produced, with these advantageous properties, in amounts sufficient for the production of therapeutic compositions.
    Type: Application
    Filed: October 17, 2013
    Publication date: May 22, 2014
    Applicant: CYTOGEL PHARMA, LLC
    Inventor: THEODORE E MAIONE
  • Advantageous hydrogel composition
    Patent number: 8246993
    Abstract: New hydrogel, including a hydrogel containing cationic BSA is included in a vaccine to stimulate the immune system to increase the potency of the vaccine.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: August 21, 2012
    Assignee: Cytogel Pharma, LLC
    Inventors: Daqing Wu, Chih-Chang Chu, Joseph Carozza
  • Method for delivering an active agent using a hydrogel composition
    Patent number: 8246994
    Abstract: New hydrogel, including a hydrogel containing cationic BSA is included in a vaccine to stimulate the immune system to increase the potency of the vaccine.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: August 21, 2012
    Assignee: Cytogel Pharma, LLC
    Inventors: Daqing Wu, Chih-Chang Chu, Joseph Carozza
  • Injectable microspheres
    Patent number: 8092835
    Abstract: Injectable microspheres are obtained from double bond functionalized polyhydric alcohol ester by a method comprising dissolving the double bond functionalized esters in a hydrophobic organic solvent, forming an aqueous solution of stabilizer, forming an oil in water emulsion where the solution of stabilizer constitutes the continuous phase and the solution of ester constitutes the disperse phase and evaporating the organic solvent or from block copolymer of PGCLM and methoxy poly(ethylene glycol).
    Type: Grant
    Filed: October 10, 2011
    Date of Patent: January 10, 2012
    Assignee: Cytogel Pharma, LLC
    Inventors: Daqing Wu, Chih-Chang Chu, Joseph Carozza
  • Injectable microspheres
    Patent number: 8034383
    Abstract: Injectable microspheres are obtained from double bond functionalized polyhydric alcohol ester by a method comprising dissolving the double bond functionalized esters in a hydrophobic organic solvent, forming an aqueous solution of stabilizer, forming an oil in water emulsion where the solution of stabilizer constitutes the continuous phase and the solution of ester constitutes the disperse phase and evaporating the organic solvent or from block copolymer of PGCLM and methoxy poly(ethylene glycol).
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: October 11, 2011
    Assignee: Cytogel Pharma, LLC
    Inventors: Daqing Wu, Chih-Chang Chu, Joseph Carozza