Abstract: The disclosure provides an optical probe comprising an optical waveguide attached to a molecular switch that produces an altered optical signal upon binding a target molecule. The disclosure also provides an optical sensor system comprising an optical probe, a light source configured to emit the excitation light to be coupled into the optical waveguide of the optical probe; and a detector.
Type:
Grant
Filed:
October 23, 2019
Date of Patent:
April 9, 2024
Assignees:
CZ Biohub SF, LLC, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Amani Hariri, Constantin Dory, Alyssa Cartwright, Jelena Vuckovic, Hyongsok Tom Soh
Abstract: Methods and compositions are provided for the treatment of Alzheimer's Disease (AD) by administering to a patient a therapeutically effective amount of an agent that inhibits signaling mediated by a bone morphogenetic protein type 1A receptor (BMPR-1A) or bone morphogenetic protein type 2 receptor (BMPR-2). Also provided are methods and compositions to increase the rate of neural stem cell self-renewal.
Type:
Application
Filed:
November 17, 2023
Publication date:
March 28, 2024
Applicants:
CZ Biohub SF, LLC, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Elizabeth Yang Chen, Felicia Reinitz, Jane Antony, Michael F. Clarke, Robert C. Jones
Abstract: The present disclosure provides materials and methods for sequencing a tissue sample and that allows spatial information about the tissue to be recovered by sequencing approaches at a single cell level.
Abstract: Provided are fusion proteins including an amino acid sequence of an ectodomain of Spike protein of a coronavirus, such as SARS-CoV-2, joined to an amino acid sequence of a ferritin subunit polypeptide. Nanoparticles including such fusion proteins, with surface-exposed trimers of the ectodomain of the Spike protein of the coronavirus, are also provided. Also provided are nucleic acids and vectors encoding the fusion proteins, cells containing such nucleic acid and vectors, immunogenic compositions including the fusion proteins, the nanoparticles, or the vectors, as well as corresponding methods and kits.
Type:
Application
Filed:
August 27, 2021
Publication date:
December 14, 2023
Applicants:
The Board of Trustees of the Leland Stanford Junior University, CZ Biohub SF, LLC
Inventors:
Abigail E. Powell, Payton Anders-Benner Weidenbacher, Natalia Friedland, Mrinmoy Sanyal, Peter S. Kim
Abstract: The present disclosure provides methods related to determining the level of afucosylated Fc glycans in IgG antibodies in a biological sample from a subject. This level can be used in methods aimed at monitoring and/or treating subject suffering from an acute flavivirus infection and/or who are at risk for progression to clinically significant infection or disease. This level can also be used in a vaccination method to ensure that those who receive a flavivirus vaccine have a reduced risk of reacting to the vaccine be developing clinically significant infection or disease. The disclosure also provides treatment methods based on inhibiting Fc?RIIA or Fc?RIIIA receptor signaling. Also provided are novel cell lines that are useful in measuring afucosylated Fc glycans.
Type:
Grant
Filed:
October 22, 2018
Date of Patent:
November 28, 2023
Assignees:
CZ Biohub SF, LLC, The Board of Trustees of the Leland Stanford Junior University
Abstract: In one aspect, methods of generating human monoclonal antibodies that specifically binds to an allergen are provided. In some embodiments, the monoclonal antibodies are generated from sequences identified from isolated single B cells from a human subject who is allergic to the allergen.
Type:
Grant
Filed:
June 17, 2021
Date of Patent:
March 28, 2023
Assignees:
CZ Biohub SF, LLC., The Board of Trustees of the Leland Stanford Junior University
Inventors:
Derek Croote, Stephen R. Quake, Kari Nadeau, Spyros Darmanis, David N. Cornfield