Abstract: A tamper-evident container comprising a vessel and a barrier that together enclose an interior space. The barrier has a marking chamber at least partially filled with a marking substance, such that when a product is inserted into the tamper-evident container through the barrier and passes through the marking chamber, the marking substance is applied to the product's surface. The presence of the marking substance on the product can indicate that it is the original product inserted into the tamper-evident container, while the absence of the marking substance on a product removed from the tamper-evident container can indicate that the original product has been replaced in the tamper-evident container with a substitute.