Abstract: A method for automatically determining whether a reagent container is new and unused or whether the reagent container has been previously used whenever reagent containers are initially placed onto an analyzer. Unused containers have a flag or lock-out member that can be dislodged or relocated by a moveable sensor probe when containers are placed onto the analyzer.

Abstract: In response to the need for highly-sensitive antibiotic susceptibility assays and identification assays that do not require extensive incubation times, the present invention provides automated assay methods and systems that permit the determination of antibiotic susceptibilities and/or microorganism identification in a timeframe that is substantially shorter than has previously been attainable using a hybrid system that combines turbimetric and fluorescence determinations using a single, clear-plastic assay platform. Related devices, kits, and components thereof are also disclosed.

Abstract: A microbiological analyzer for performing ID tests on samples using colorimetric techniques to generate a pixel-wise colored map of a test region of interest and also performing MIC tests on samples using nephelometric techniques to determine which antimicrobial agents are most effective against a particular microorganism.

Abstract: A cup-like broth container comprising four mutually opposed pairs of connected sidewalls with a protruding rib formed on each of four perpendicularly opposed single sidewalls and four Y-shaped clamping ridges attached to and extending outwardly from a single one of the four sidewalls located between the four sidewalls having a protruding rib.

Abstract: A method for generating a vortex-like mixing action within a liquid held in a container by causing the container to move back and forth in a constant sinusoidal pattern at high speeds. Momentum forces acting upon the liquid solution cause it to generate an internal mixing motion of the liquid solution without the aid of extraneous mixing members.

Abstract: A closed elongate canister having a generally rectangular cross-section formed by a front wall, a five-section back wall and two side walls, the walls of dimensions to house a plurality of ID test rotors stacked one atop another within the canister.

Abstract: An aliquot vessel array having notched side flanges and rails of a next adjacent so that a plurality of arrays may be attached one atop another in a secure stack. Stacked aliquot vessel arrays may be simultaneously loaded into a storage unit on an automatic analyzer and automatically dispensed into a sampling track as required. The aliquot vessel array has certain handling features to ensure safe and reliable movement between the storage unit and sampling tracks.

Abstract: A multi-analyzer system where at least two automatic clinical analyzers are linked together by a bi-directional sample rack shuttle, both analyzers initially capable of performing a slightly different menu of assays. The bi-directional incoming and outgoing sample rack transport system of a first one of the two analyzers is automatically converted into a one-way incoming sample rack transport system adapted and the incoming sample tube transport system of a second of the two analyzers is automatically converted into a one-way outgoing transport system adapted to dispose of all sample racks having sample tubes with samples finally tested by either analyzer. In the event that one of the two analyzers experiences an operating failure, the analyzer system may automatically revert to a single analyzer system employing only the operational analyzer.

Abstract: The present application relates to a method of making liposomes having membrane proteins incorporated therein, the method comprising: providing the membrane protein in solution; providing a solution of preformed liposomes; and incubating the mixture. Prior to the step of providing a solution of preformed liposomes, the liposomes are formed by combining a mixture of phospholipids with a solution of at least one type of unsaturated fatty acid. The methods of the present invention further relate to the method of making a reagent comprising tissue factor reconstituted into preformed liposomes. The method of the present invention for making a tissue factor reagent comprises: providing tissue factor in solution; providing a solution of preformed liposomes comprising a mixture of phospholipids and at least one type of unsaturated fatty acid; and incubating the mixture.

Abstract: The present invention provides bioactive porous partition members for use in connection with studies or tests of the blood coagulation process, wherein the porous partition members have an aperture and have incorporated therein at least one agent capable of initiating blood coagulation or platelet aggregation.

Abstract: A microbiological test array with a generally flat base having a plurality of upwardly projecting microwells connected by a microchannel to an open reservoir formed in a top surface generally parallel to the base of the test array. The reservoir has an opening to permit an inoculum-broth liquid solution to flow from the reservoir through the microchannel, to a sacrificial evaporation well having an air vent port adapted to control a vacuum filling process, and subsequently to be distributed into each of the plurality of microwells.

Abstract: The present invention relates generally to the field of prothrombin time reagents for determining dysfunction in the coagulation system and more specifically to reagents made from native thromboplastin or purified or recombinant tissue factor and phospholipids from a natural or synthetic source. The present invention relates to methods to make a diagnostic reagent that includes a membrane-bound protein incorporated into a liposome and having additional empty liposomes (liposomes without membrane-bound protein incorporated therein) added to the solution.

Abstract: The present invention relates to a method for detecting the amount of a target polynucleotide in a sample. A combination is provided in a medium. The combination comprises (i) a sample suspected of containing the target polynucleotide, the target polynucleotide being in single stranded form, (ii) a reference polynucleotide comprising a sequence that is common with a sequence of the target polynucleotide, and (iii) a predetermined amount of an oligonucleotide probe that has a sequence that hybridizes with the sequence that is common. The combination is subjected to conditions for amplifying the target polynucleotide and the reference polynucleotide. The conditions permit formation of substantially non-dissociative complexes of the target polynucleotide and the reference polynucleotide, respectively, with the oligonucleotide probe. Furthermore, the predetermined amount of the oligonucleotide probe is less than the expected amount of the amplified target polynucleotide.

Abstract: A magnetic sample rack adapted to support liquid containers is urged along a surface by means of a magnetic conveyor system located beneath the surface. The magnetic conveyor system comprises a plurality of magnetic housings driven by a belt, the magnetic housings including a magnet slideably contained in a closed upper cavity. Magnetic forces emanating from the magnet overcome frictional resistive forces between the sample racks and the operating surface and move the sample racks along input and output lanes defined in the operating surface. Abrupt movements of the sample racks are eliminated because the housing magnet slides smoothly towards the sample rack, secures the sample rack, and pulls the rack along the operating surface as the housings are moved at a steady rate by the belt.

Abstract: This invention relates to binding protein assays. In particular, this invention relates to binding protein assays for B12 and folate in serum or plasma. More specifically, this invention provides a sequential assay that uses a combination of specific binding proteins, and anti-binding protein antibodies to measure B12 and folate in serum or plasma.

Abstract: According to the present invention highly specific-low affinity antibodies are generated which allow for the assay of F1.2 in bodily fluids that also contain prothrombin or other plasma proteins. Antibodies having the necessary properties for this assay are made using synthetic polypeptides which mimic the carboxy terminus of F1.2.

Abstract: A closed elongate canister having a generally rectangular cross-section formed by a front wall, a five-section back wall and two side walls, the walls of dimensions to house a plurality of ID test rotors stacked one atop another within the canister.