Abstract: Provided is a mutant UDG having improved thermal sensitivity compared to a wild-type UDG. The mutant UDG of the presently claimed subject matter having a high thermal sensitivity has no inhibitory effect on the PCR reaction and thus can be advantageously used for the development of PCR/qPCR Premix and particularly PCR diagnostic kits employing UDG which requires the use of relatively low temperature in melting and amplification steps.

Abstract: Disclosed is a cyber-physical system for detecting a pole-dynamics attack, including an attack detector configured to receive a sensor signal output from a physical system and to output an attack detection signal based on the received sensor signal, and a mode controller configured to receive the sensor signal and to output an input control signal for controlling the physical system based on the received sensor signal, wherein the mode controller controls a normal control (NC) mode and an attack detection control (ADC) mode for detecting pole-dynamics attack (PDA) from an output to be repeatedly executed at a preset switching period.

Abstract: The present invention relates to a surface acoustic wave-based material measuring device, material measuring system, and material measuring method, and more particularly, to a technique of accurately and reliably measuring various inherent physical properties of temperature and frequency-dependent materials by generating multiple resonant waves.

Abstract: Disclosed is a particle-measuring device, including: a measurement part including first and second electrodes and measuring a mass of particles with a change in signals transmitted and received between the first and second electrodes, wherein the first and second electrodes are patterned on a base made of a piezoelectric material and transmit/receive signals to/from each other; and an adsorption part provided in an adsorption region between the first and second electrodes and configured to adsorb fine particles according to a temperature change. According to such a configuration, the particle-measuring device does not interfere with the resonance rate of a piezoelectric material while having a high adsorption rate, thereby providing excellent particle measurement quality.

Abstract: Disclosed is a magnetic-piezoelectric micro robot capable of a hyperthermia treatment, an electrotherapy and a cell therapy. The magnetic-piezoelectric micro robot includes a body and a stimulus generating layer formed at a surface of the body including a magnetic particle and a piezoelectric particle and generating heat from the magnetic particle and generating an electrical stimulus from the piezoelectric particle by an external stimulus, wherein one of a hyperthermia treatment by the magnetic particle or an electrotherapy by the piezoelectric particle is performed or both are performed simultaneously.

Abstract: Provided is a magnetic actuation system controlling a magnetic microrobot, a magnetic actuation catheter, or a guide wire by using a magnetic field, and more particularly, a magnetic actuation system compatible with a C-arm that is applied to the C-arm, which is a mobile X-ray fluoroscopy device, in order to enable control of the microrobot or a catheter treatment in a human body by using the C-arm.

Abstract: Provided are a magnetic actuation device using a permanent magnet which may generate a magnetic field for a long time with lower power and lower heat by using the permanent magnet, and a system using the same. The magnetic actuation device may utilize the plurality of permanent magnets for controlling an alignment direction with two degrees of freedom to thus exclude an actuation element limiting space utilization, such as a robot arm, thus allowing an operator using a medical device to perform a safe procedure on a patient.

Abstract: Disclosed is a force sensor. More particularly, the force sensor includes a first permanent magnet layer; a magnetic tunnel junction disposed on the first permanent magnet layer and configured to have a preset resistance value; and a second permanent magnet layer disposed to be spaced apart from the magnetic tunnel junction, wherein the second permanent magnet layer moves in a direction of the first permanent magnet layer when pressure is applied from outside, the preset resistance value of the magnetic tunnel junction is changed when a magnetic field strength formed between the first permanent magnet layer and the second permanent magnet layer becomes a preset strength or more according to movement of the second permanent magnet layer, and the force sensor senses the pressure based on a change in the preset resistance value.

Abstract: An apparatus and method for data fusion between heterogeneous sensors are disclosed. The method for data fusion between the heterogeneous sensors may include identifying image data and point cloud data for a search area by each of a camera sensor and a LiDAR sensor that are calibrated using a marker board having a hole; recognizing a translation vector determined through calibrating of the camera sensor and the LiDAR sensor; and projecting the point cloud data of the LiDAR sensor onto the image data of the camera sensor using the recognized translation vector to fuse the identified image data and point cloud data.

Abstract: The present disclosure relates to the preparation of citrullinated vimentin antigen-specific immune tolerogenic dendritic cells and a composition for preventing or treating heart failure after myocardial infarction comprising the same. According to the present disclosure, it is confirmed that immune tolerogenic dendritic cells differentiated by treating immature dendritic cells with citrullinated vimentin regulate the expression of immune-related factors and have an excellent therapeutic effect on heart failure caused by myocardial infarction.

Abstract: An image processing method of the present disclosure may include receiving a scanned image, and processing the received image through an octave convolution-based neural network to output a high-quality image and an edge image for the received image. The octave convolution-based neural network may include a plurality of octave encoder blocks and a plurality of octave decoder blocks. Each octave encoder block may include an octave convolutional layer, and may be configured to output a high-frequency feature map and a low-frequency feature map for the image.

Abstract: Provided are a novel nickel foam having a hierarchical pore structure, a method of producing the same, and an application thereof. Unlike a conventional nickel foam, the nickel foam has a well-developed hierarchical pore structure including pores having a size of 4 ?m or less in addition to inherent macropores having a size of 100 ?m to 900 ?m, and thus, may have a significantly large specific surface area. Accordingly, the nickel foam may be variously applied to an electrochemical reaction such as a water electrolysis system and an exhaust gas purification filter.

Abstract: The present invention provides a stator and a motor assembly including the same. The stator includes: a stator core disposed outside a rotor core and having an inner surface inclined with respect to a rotation axis of a rotor; a plurality of coil-wound teeth extending from the inner surface of the stator core towards the rotation axis, wherein a coil is wound around each of the plurality of coil-wound teeth; and openings formed by sidewalls of the plurality of coil-wound teeth and the inner surface of the stator core, wherein a cross-sectional area of the openings changes along a direction of the rotation axis.

Abstract: Disclosed are a drug evaluation method and apparatus. The drug evaluation method includes acquiring cell images in response to a drug to be evaluated, loading an image processing-based learning model trained so as to predict molar concentrations, outputting molar concentrations of cells corresponding to the cell images by applying the learning model to the acquired cell images, and calculating a drug evaluation value used to evaluate effects of the drug on the cells based on the molar concentrations of the cells corresponding to the cell images output through the learning model.

Abstract: Provided is a pharmaceutical composition for enhancing the anticancer effect of cancer. More specifically, it was confirmed that when a composition including an IU1-series compound known to inhibit ubiquitin-specific protease 14 (USP14), which is a deubiquitinase, is administered in combination with and proteolysis-targeting chimera (PROTAC), the cancer prevention or treatment effect of PROTAC was significantly enhanced. Furthermore, with the pharmaceutical composition of the present disclosure, cancer can be effectively treated even when a lower dose of PROTAC is used, thereby freeing from the problems of toxicity and side effects, and improving the application limitations and problems arising from the sole use of PROTAC. Accordingly, the combinatorial treatment of PROTAC and IU1-series compound can be widely used in the field of cancer treatment.

Abstract: The present invention relates to a composition, for prevention or treatment of cancer diseases, comprising CD8+ T cells activated by CD4+ T cell-derived extracellular vesicles as an active ingredient. It was found that the secretion of extracellular vesicles from cytokine-activated CD4+ T cells increases and the extracellular vesicles enhance proliferation and activity of CD8+ T cells to induce the death of cancer cells, thereby augmenting an anticancer effect. Thus, the present invention provides the CD8+ T cells activated by CD4+ T cell-derived extracellular vesicles as a pharmaceutical agent or an immunotherapeutic agent for cancer diseases, and a method for activating CD8+ T cells by using CD4+ T cell-derived extracellular vesicles to prepare CD8+ T cells showing excellent anticancer activity as described above.

Abstract: The present invention relates to a composition containing IL-2 or an expression promoter or activator thereof as an active ingredient for prevention or treatment of cancer disease. In the present invention, it was discovered that when treating cancer cells with IL-2, an anticancer effect was enhanced by inhibiting the secretion of cancer cell-derived exosomes and the expression of PD-L1 inducing immune escape of T cells. IL-2 was also discovered to effectuate the anticancer effect directly on cancer cells compared to conventional techniques exhibiting an immune anticancer effect by activating cytotoxic T cells. Thus, IL-2 or an expression promoter or activator thereof can be advantageously used in a composition for prevention or treatment of cancer diseases.

Abstract: Provided is an implantable biosensor including an intermediate layer; a first electrode layer provided on one surface of the intermediate layer and including a first electrode configured to react with a bio material and an auxiliary electrode electrically connected to the first electrode; and a second electrode layer provided on another surface of the intermediate layer to face the first electrode layer and including a second electrode operating as a reference electrode.

Abstract: The present invention relates to a composition for preventing or treating a neuroinflammatory disease, which can inhibit the expression of neuroinflammatory cytokines, promote the degradation of amyloid beta, and improve a cognitive function in an animal model of Alzheimer's disease. More specifically, the present invention relates to a composition for preventing or treating a neuroinflammatory disease comprising didanosine or a pharmaceutically acceptable salt thereof, and the composition may be used for the development of drugs and quasi-drug materials.

Abstract: The present invention relates to a technical idea for providing a delivery service on regular and irregular roads using autonomous vehicles. More specifically, the present invention relates to technology in which, on a regular road, a lead vehicle and at least one droid vehicle are coupled to each other and a delivery service is provided based on autonomous driving; and on an irregular road, the coupling between the lead vehicle and the droid vehicle is automatically released and the droid vehicle provides a delivery service by remotely controlling the driving of the droid vehicle by the lead vehicle in the last mile delivery section corresponding to the irregular road.