Abstract: The present invention relates to a paclitaxel composition and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4 to 90% by weight of at least one selected from the monoglycerides, 0.01 to 90% by weight of at least one oil and 0.01 to 20% by weight of paclitaxel. Also the present invention relates to a paclitaxel composition including emulsifiers and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4 to 90% by weight of at least one selected from the monoglycerides, 0.01 to 90% by weight of at least one emulsifier and 0.01 to 20% by weight of paclitaxel. The composition of the present invention is an effective paclitaxel delivery system since the composition solubilizes paclitaxel, does not form aggregates after being dispersed in water, adsorbs well on the intestinal wall, and therefore has high bioavailability.
Type:
Grant
Filed:
July 18, 2003
Date of Patent:
December 13, 2011
Assignee:
Daehwa Pharm. Co., Ltd.
Inventors:
Hesson Chung, Seo-Young Jeong, Ick-Chan Kwon, Yeong-Taek Park, In-Hyun Lee, Soon-Hong Yuk, Young-Wook Choi, Jae-Hyung Park, Jin-Wook Chung
Abstract: Oily paclitaxel composition and formulation for chemoembolization and preparation method thereof solubilizing paclitaxel in an oily contrast medium. The composition of the present invention solubilizes paclitaxel and has an advantage of delivering anticancer drug to the target cells by chemoembolization since it is possible to visualize the blood vessel during the chemoembolization process. The present invention also relates to oily paclitaxel composition and formulation additionally comprising chemicals that prevent paclitaxel precipitation for prolonged preservation and the preparation method thereof. Since the composition of the present invention solubilize paclitaxel effectively and can be visualized during chemoembolization, it can be used for TACE to treat hepatoma and other solid tumors.
Type:
Application
Filed:
August 12, 2009
Publication date:
February 18, 2010
Applicant:
Daehwa Pharm. Co., Ltd.
Inventors:
Hesson Chung, Seo Young Jeong, Ick Chan Kwon, Yeong Taek Park, In Hyun Lee, Jae Hyung Park, Jin Wook Chung, Young Man Kim