Abstract: A sustained release suppository comprising in a usual suppository basea) a water-soluble therapeutically active substance, the average particle size of which is smaller than 20 .mu.m,b) a physiologically acceptable organic substance which is swellable in contact with water, andc) hydrophobic silicium dioxide.The suppository base is usually a fat having a melting range of from 29.degree. to 38.degree. C. As ingredient b) cellulose derivatives such as hydroxypropylmethylcellulose may be used, in a quantity of from 5 to 40% by weight, preferably 9 to 15% by weight. Ingredient c) is preferably used in a quantity of from 3 to 6% by weight. Also a process for manufacturing the suppositories is described.
Type:
Grant
Filed:
December 15, 1992
Date of Patent:
July 25, 1995
Assignee:
Dagra Pharma B.V.
Inventors:
Tjoe H. Jauw, Hendrik W. Frijlink, Frits Moolenaar, Peter Meijlink
Abstract: This invention relates to an ophthalmic preparation of povidone iodine in a packaging of bottle glass type I or polyethyleneterephthalate with a dropper of polypropylene, polyethylene and/or polytetrafluoroethylene coated bromobutyl rubber.