Abstract: The present invention relates to certain labelled or un-labelled pyrrolyl-oxadizolyl-diazabicyclononane derivatives and their medical use. Furthermore, the present invention relates to the use of said derivatives in their labelled form in diagnostic methods, in particular for in vivo receptor imaging (neuroimaging).
Type:
Grant
Filed:
April 3, 2012
Date of Patent:
March 24, 2015
Assignee:
DanPET AB
Inventors:
Dan Peters, Daniel B. Timmermann, Elsebet Østergaard Nielsen
Abstract: This invention relates to diazabicyclononyl oxadiazolyl derivatives, which are found to-be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances. Ar1 represents a pyrrolyl group, optionally substituted with alkyl or halo-alkyl.
Type:
Grant
Filed:
December 16, 2010
Date of Patent:
February 3, 2015
Assignee:
Danpet AB
Inventors:
Dan Peters, Daniel B. Timmermann, Elsebet Østergaard Nielsen, Tino Dyhring, Philip K. Ahring
Abstract: This invention relates to novel indolyl-oxadiazolyl-diazabicyclononane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
Type:
Grant
Filed:
January 25, 2010
Date of Patent:
July 15, 2014
Assignee:
Danpet AB
Inventors:
Dan Peters, Daniel B. Timmermann, Tino Dyhring, Jeppe Kejser Christensen, Elsebet Østergaard Nielsen
Abstract: The present invention relates to certain labelled or un-labelled pyrrolyl-oxadizolyl-diazabicyclononane derivatives and their medical use. Furthermore, the present invention relates to the use of said derivatives in their labelled form in diagnostic methods, in particular for in vivo receptor imaging (neuroimaging).
Type:
Application
Filed:
April 3, 2012
Publication date:
January 30, 2014
Applicant:
DANPET AB
Inventors:
Dan Peters, Daniel B. Timmermann, Elsebet Østergaard Nielsen