Abstract: The invention refers to small peptides with low hemolytic activity, presenting similar antiparasitic, antifungal and antibacterial activities. More specifically, it refers to a peptide called gomesin, with 18 amino acid residues, configured as a hairpin structure consisting of two anti-parallel beta-folded sheets joined by a beta turn, containing four invariable residues of cysteine forming two disulphide bridges, configurable as a cyclic chain with open or closed ends.
Type:
Grant
Filed:
May 10, 2006
Date of Patent:
May 25, 2010
Assignee:
De Sao Paulo Universida de
Inventors:
Sirlei Daffre, Pedro Ismael Da Silva, Jr., Philippe Bulet