Abstract: Improved healing of wounds, particularly wounds of the eye, such as keratorefractive surgical incisions, is obtained by coating the wound surfaces with a solution containing a protein crosslinking compound such as dimethyl pimelimidate dihydrochloride, followed by treatment with a composition containing an extracellular matrix material such as fibronectin, a biologically active fragment or an analog thereof.
Type:
Grant
Filed:
June 25, 1990
Date of Patent:
October 1, 1991
Assignees:
Chiron Ophthalmics, Inc., Dean A. McGee Eye Inst.
Inventors:
David Gibson, Michael Lerner, Robert Nordquist, Cary Reich