Abstract: A formulation for non-invasive delivery of pharmaceutical agents, particularly proteins and peptides, by absorption through a membrane at a targeted site is provided, along with a process of making the formulation. The formulation comprises a suspension of solid-phase dehydrated particles in a delivery medium. The particles comprise the dehydration product of the pharmaceutical agent and at least one of a surfactant and permeation enhancer, and the delivery medium preferably comprises a propellant for pressurized aerosol delivery of the formulation. The formulation can be conveniently delivered to the patient's targeted site where the pharmaceutical agent is absorbed through the mucosa to achieve a desired bioavailability.
Type:
Grant
Filed:
June 2, 2000
Date of Patent:
November 26, 2002
Assignee:
DelRx Pharmaceutical Corp.
Inventors:
Randall McCoy, Miles Augustus Libbey, III, Jle Liu, Robert O. Williams, III