Patents Assigned to DENOVOMATRIX GMBH
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Patent number: 11648320Abstract: The present invention provides a biomatrix layer comprising, consisting essentially of or consisting of a sulfated oligosaccharide at a concentration in the range of 0.1 ?M to 1,000 ?M and a peptide-polyethylene glycol-conjugate according to formula (I): PEG-R1-(BX)n (I) wherein B is lysine or arginine, X is selected from alanine, glycine, serine, threonine, tyrosine, glutamic acid or aspartic acid and n is an integer selected from 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20; R1 may be absent or is a peptide comprising 5 to 30 amino acids; PEG is comprised at a concentration in the range of 0.1 ?M to 1,000 ?M; R1, if present, is comprised at a concentration in the range of 0.1 ?M to 4,000 ?M; (BX)n is comprised at a concentration in the range of 0.25 ?M to 1,000 ?M. The invention further relates to processes for assembling the biomatrix layer.Type: GrantFiled: June 18, 2018Date of Patent: May 16, 2023Assignee: DENOVOMATRIX GMBHInventors: Yixin Zhang, Alvin Thomas, Richard Wetzel, Dejan Husman, Robert Wieduwild
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Patent number: 11523990Abstract: The invention relates to a hydrogel matrix comprising a mixture of a covalent peptide-polymer conjugate and an oligosaccharide; wherein the oligosaccharide is a highly negatively charged sulfated oligosaccharide selected from the group consisting of heparin, dextran sulfate, ?-cyclodextrin sulfate, ?-cyclodextrin sulfate and ?-cyclodextrin sulfate; wherein said polymer comprised in said peptide-polymer conjugate is a linear or multi-arm polyethylene glycol; wherein said peptide comprised in said peptide-polymer conjugate is a peptide, which consists of an amino acid sequence selected from the group consisting of SEQ ID NO.4, SEQ ID NO.5, SEQ ID NO. 18 and SEQ ID NO. 19; and wherein said hydrogel matrix is configured in the form of an oligosaccharide/peptide/polymer system, in which said peptide is chemically conjugated to the polymer such that the hydrogel is obtained by mixing the peptide-polymer conjugate and the oligosaccharide.Type: GrantFiled: September 4, 2019Date of Patent: December 13, 2022Assignee: DENOVOMATRIX GMBHInventors: Robert Wieduwild, Yixin Zhang, Carsten Werner, Mikhail Tsurkan, Uwe Freudenberg
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Patent number: 11166907Abstract: The present invention provides a conductive hydrogel comprising a polystyrene sulfonate compound selected from poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), reduced graphene oxide polystyrene sulfonate (rGO:PSS) and rGO:PEDOT:PSS; and a conjugate of polyethylene glycol (PEG) and a linker-(BX)n oligopeptide of formula (I) PEG-linker-(BX)n??(I) wherein B is lysine or arginine, X is selected from alanine, glycine, serine, threonine, tyrosine, glutamic acid or aspartic acid and n is an integer selected from 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20. The invention further relates to processes for assembling the conductive hydrogel. The conductive hydrogel can be used in various biomedical applications, such as neuroprostheses, biosensors, nerve grafts, cell culture and encapsulation of cells and microorganisms as well as for drug delivery.Type: GrantFiled: April 27, 2018Date of Patent: November 9, 2021Assignee: DENOVOMATRIX GMBHInventors: Yixin Zhang, Yong Xu, Alvin Thomas
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Publication number: 20210145980Abstract: The present invention provides a biomatrix layer comprising, consisting essentially of or consisting of a sulfated oligosaccharide at a concentration in the range of 0.1 ?M to 1,000 ?M and a peptide-polyethylene glycol-conjugate according to formula (I): PEG-R1-(BX)n (I) wherein B is lysine or arginine, X is selected from alanine, glycine, serine, threonine, tyrosine, glutamic acid or aspartic acid and n is an integer selected from 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20; R1 may be absent or is a peptide comprising 5 to 30 amino acids; PEG is comprised at a concentration in the range of 0.1 ?M to 1,000 ?M; R1, if present, is comprised at a concentration in the range of 0.1 ?M to 4,000 ?M; (BX)n is comprised at a concentration in the range of 0.25 ?M to 1,000 ?M. The invention further relates to processes for assembling the biomatrix layer.Type: ApplicationFiled: June 18, 2018Publication date: May 20, 2021Applicant: DENOVOMATRIX GMBHInventors: Yixin ZHANG, Alvin THOMAS, Richard WETZEL, Dejan HUSMAN, Robert WIEDUWILD
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Publication number: 20200188294Abstract: The present invention provides a conductive hydrogel comprising a polystyrene sulfonate compound selected from poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), reduced graphene oxide polystyrene sulfonate (rGO:PSS) and rGO:PEDOT:PSS; and a conjugate of polyethylene glycol (PEG) and a linker-(BX)n oligopeptide of formula (I) PEG-linker-(BX)n ??(I) wherein B is lysine or arginine, X is selected from alanine, glycine, serine, threonine, tyrosine, glutamic acid or aspartic acid and n is an integer selected from 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20. The invention further relates to processes for assembling the conductive hydrogel. The conductive hydrogel can be used in various biomedical applications, such as neuroprostheses, biosensors, nerve grafts, cell culture and encapsulation of cells and microorganisms as well as for drug delivery.Type: ApplicationFiled: April 27, 2018Publication date: June 18, 2020Applicant: DENOVOMATRIX GMBHInventors: Yixin ZHANG, Yong XU, Alvin THOMAS
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Publication number: 20200179280Abstract: The invention relates to a hydrogel matrix comprising a mixture of a covalent peptide-polymer conjugate and an oligosaccharide; wherein the oligosaccharide is a highly negatively charged sulfated oligosaccharide selected from the group consisting of heparin, dextran sulfate, ?-cyclodextrin sulfate, ?-cyclodextrin sulfate and ?-cyclodextrin sulfate; wherein said polymer comprised in said peptide-polymer conjugate is a linear or multi-arm polyethylene glycol; wherein said peptide comprised in said peptide-polymer conjugate is a peptide, which consists of an amino acid sequence selected from the group consisting of SEQ ID NO.4, SEQ ID NO.5, SEQ ID NO. 18 and SEQ ID NO. 19; and wherein said hydrogel matrix is configured in the form of an oligosaccharide/peptide/polymer system, in which said peptide is chemically conjugated to the polymer such that the hydrogel is obtained by mixing the peptide-polymer conjugate and the oligosaccharide.Type: ApplicationFiled: September 4, 2019Publication date: June 11, 2020Applicant: DENOVOMATRIX GMBHInventors: Robert WIEDUWILD, Yixin ZHANG, Carsten WERNER, Mikhail TSURKAN, Uwe FREUDENBERG