Abstract: Described herein are methods, systems, and compositions for non-invasively diagnosing or detecting a skin disease or disorder. Diagnosing or detecting a non-melanoma skin cancer as provided herein comprises detecting gene expression levels of a set of identified genes and in some instances further detecting mutations in a gene of interest.
Type:
Grant
Filed:
February 14, 2019
Date of Patent:
May 7, 2024
Assignee:
DERMTECH, INC.
Inventors:
John Daniel Dobak, III, Burkhard Jansen, Zuxu Yao
Abstract: The present invention provides methods for diagnosing melanoma and/or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and/or dysplastic nevi and/or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.
Abstract: Disclosed herein are methods of detecting an altered gene expression levels in a subject suspected of having atopic dermatitis. Further described herein are methods of treating atopic dermatitis in a subject having an exhibiting an altered gene expression level.
Type:
Grant
Filed:
March 26, 2021
Date of Patent:
May 9, 2023
Assignee:
DERMTECH, INC.
Inventors:
John Daniel Dobak, III, Burkhard Jansen, Zuxu Yao
Abstract: Disclosed herein, in certain embodiments, are methods of detecting the presence of a skin cancer based on molecular risk factors. In some instances, the skin cancer is cutaneous T cell lymphoma (CTCL). In some cases, the skin cancer is mycosis fungoides (MF) or Sézary syndrome (SS).
Type:
Grant
Filed:
March 24, 2020
Date of Patent:
February 14, 2023
Assignee:
DermTech, Inc.
Inventors:
John Daniel Dobak, III, Burkhard Jansen, Zuxu Yao
Abstract: The present invention provides methods for diagnosing melanoma and/or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and/or dysplastic nevi and/or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.
Abstract: The subject matter described herein provides non-invasive tape stripping methods for the collection of a skin sample. The tape stripping method includes applying and removing at least one adhesive tape, provided that a skin sample is adhered to the adhesive tape after removal. The at least one adhesive tape is supplied in an adhesive skin sample collection kit. The adhesive skin sample collection kit further comprises a sample collector and instructions for use sheet.
Type:
Grant
Filed:
April 29, 2016
Date of Patent:
July 14, 2020
Assignee:
DERMTECH, INC.
Inventors:
Tara J. Palmer, John P. Alsobrook, II, John Dobak
Abstract: The present invention provides methods for diagnosing melanoma and/or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and/or dysplastic nevi and/or normal pigmented skin. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample.