Abstract: A fluorescence microscope instrument includes a light source; an objective focusing light from the light source into a sample and collecting fluorescence light emitted out of the sample; a detector detecting the fluorescence light; and a beam path separator arranged in a first beam path between the light source and the objective and in a second beam path between the objective and the detector. Wavelengths of the light to be directed to the sample and of the fluorescence light to be detected by the detector fall into an extended range of wavelengths. The beam path separator separates the two beam paths in that it is transferable between being transparent for any wavelength of the range of wavelengths and coming along the first beam path, and a second state in which it is transparent for any wavelength of the range of wavelengths and coming along the second beam path.

Abstract: The present invention relates to the field of cancer therapy. Specifically, a chemotaxis fusion-receptor that directs bacteria towards tumors is disclosed. Further encompassed by the present invention is a bacterial cell that comprises at least one chemotaxis fusion-receptor and, preferably, a killing module for the destruction of tumor cells.

Abstract: Described is a double-transfected cell line containing (a) a DNA sequence encoding an uptake transporter for organic anions, preferably OATP8, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates, preferably the multidrug resistance protein 2 (MRP2), operatively linked with a promoter. Moreover, various uses of said cell line are described, preferably its use for the identification of transport inhibitors, e.g. drug candidates.

Abstract: The present invention relates to chimeric virus-like particles (cVLPs) or chimeric capsomers (cCs) from BPV, fusion proteins and DNAs coding for said proteins and to the use of cVLPs or cCs for the immunization of ungulates, especially horses.

Abstract: The invention relates to a compound which contains boron and which comprises the following general formula (1) in which Cb represents carborane, R2 and R3, independent of one another, represent a hydrogen atom or an organic radical, and R and R1, independent of one another, represent a hydrogen atom or an organic group, or R and R1 form a carbonyl group with the carbon atom to which they are bound. The invention also relates to a method of producing a compound containing boron and to the application of the same.

Abstract: The present invention is directed to a method or system for reproducing a 3D object, in particular for modeling a pathologic preparation, with the following steps: providing picture data of the 3D object, such as of a pathological preparation, smoothing and/or equalizing the picture data so as to obtain modified picture data from the object with a minimum of deviations from the 3D object and transferring the resulting picture data to corresponding grid system data.

Abstract: This invention relates to a conjugate, comprising a saccharide and one or more therapeutic or diagnostic agents, as well as the use of the conjugate. The conjugate of the present invention may be used for diagnosing cancer or viral diseases. The conjugate of the present invention may also be used to prevent and/or treat neurological diseases.

Abstract: The present invention is directed to a method of inhibiting the growth of cancer cells in a lower animal host through the use of phorbol.