Patents Assigned to Deutches Krebsforschungszentrum Stiftung des Offentlichen Rechts
  • USE OF BACTERIA FOR THE SENSING AND KILLING OF CANCER CELLS
    Publication number: 20110293567
    Abstract: The present invention relates to the field of cancer therapy. Specifically, a chemotaxis fusion-receptor that directs bacteria towards tumors is disclosed. Further encompassed by the present invention is a bacterial cell that comprises at least one chemotaxis fusion-receptor and, preferably, a killing module for the destruction of tumor cells.
    Type: Application
    Filed: October 26, 2009
    Publication date: December 1, 2011
    Applicants: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG, DKFZ DEUTCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS
    Inventors: Roland Eils, Philip Hundeshagen, Yara Reis, Daniela Richter, Jens Keienburg, Michaela Reichenzeller, Michael Flossdorf, David Kentner, Erik Sommer, Victor Sourjik, Barbara Di Ventura, Philip Bayer, Yin Cai, Maximilian Hörner, Stephen Kraemer, Pascal Krämer, Andreas Kühne, Christian Moritz, Maria Renner, Dominik Niopek, Kathrin Nussbaum, Kolja Schleich, Markus Stahlberg, Anna Stöckl, Chenchen Zhu, Marika Ziesack, Adjana Eils, Nikita Vladimirov
  • Double-transfected cell line useful for the identification of transport inhibitors
    Patent number: 7229825
    Abstract: Described is a double-transfected cell line containing (a) a DNA sequence encoding an uptake transporter for organic anions, preferably OATP8, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates, preferably the multidrug resistance protein 2 (MRP2), operatively linked with a promoter. Moreover, various uses of said cell line are described, preferably its use for the identification of transport inhibitors, e.g. drug candidates.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: June 12, 2007
    Assignee: Deutches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Yunhai Cui, Joerg Koenig, Dietrich Keppler
  • Chimeric virus-like particle or chimeric capsomers from BPV
    Patent number: 6953579
    Abstract: The present invention relates to chimeric virus-like particles (cVLPs) or chimeric capsomers (cCs) from BPV, fusion proteins and DNAs coding for said proteins and to the use of cVLPs or cCs for the immunization of ungulates, especially horses.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: October 11, 2005
    Assignee: Deutches Krebsforschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Lutz Gissman, Martin Müller, Hermann Müller
  • Saccharide conjugates
    Patent number: 6489302
    Abstract: This invention relates to a conjugate, comprising a saccharide and one or more therapeutic or diagnostic agents, as well as the use of the conjugate. The conjugate of the present invention may be used for diagnosing cancer or viral diseases. The conjugate of the present invention may also be used to prevent and/or treat neurological diseases.
    Type: Grant
    Filed: April 20, 1998
    Date of Patent: December 3, 2002
    Assignee: Deutches Krebsforschungszentrum Stiftung Des Offentlichen Rechts
    Inventors: Manfred Wiessler, Konrad Beyreuther