Abstract: The invention relates to plasmids derived from pBluescript KS(+), which contains more than 1, preferably 2, 7, 14, 21 and 27, respective SK primer elements, and their use in analytical electron microscopy.
Type:
Grant
Filed:
March 1, 2002
Date of Patent:
June 1, 2004
Assignee:
Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen
Rechts
Inventors:
Sabine Bub, Helmut Troester, Karsten Richter, Ansgar Haking, Stefan Raddatz, Manfred Wiessler, Eberhard Spiess, Michael Trendelenburg
Abstract: The invention relates to a collimator (1) for limiting a bundle of high-energy rays (2), which is emitted by a substantially point-like radiation source (3) and directed towards a treatment object (20) and used in particular for the stereotactic conformation radiotherapy of tumors. According to the invention the collimator (1) comprises a plurality of diaphragm leaves (4, 4′) which are arranged opposite each other and which are made of a radiation-absorbing material and which, by means of drive mechanisms, can be moved into the optical path in such a way that the contours and/or exposure period of said optical path can be freely defined, the front edges (5, 5′) of the diaphragm leaves (4, 4′) being parallel to the optical path at all times.
Type:
Grant
Filed:
July 26, 2001
Date of Patent:
May 4, 2004
Assignee:
Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen
Rechts
Inventors:
Otto Pastyr, Gernot Echner, Wolfgang Schlegel, Walter Ganter
Abstract: The invention relates to a displacement-detecting element (1) comprising a measuring resistance (2), voltage source (3) and a displacement-dependent voltage pick off (4). The measuring resistance (2) is embodied in the form of a strip. The length of the resistor (6) corresponds to at least the maximal length of displacement (7) of the component to be detected. The invention also relates to a multileaf collimator (23) having such a displacement-detecting element (1). The aim of the invention is to produce a displacement-detecting element (a) for detecting the position of the leaves (22) in a multileaf collimator (23) in a precise and faultless manner.
Type:
Grant
Filed:
May 27, 2003
Date of Patent:
February 24, 2004
Assignee:
Deutsches Krebsforschungszentrum Stiftung des Oeffentlichen
Rechts
Inventors:
Otto Pastyr, Gernot Echner, Wolfgang Schlegel
Abstract: The present invention relates to a method for the photolithographic synthesis of biochips in which photolabile protective groups of the 2-(2-nitrophenyl)ethyl type are used, whereby the irradiation step that is common in the photolithographic chip synthesis is carried out in the presence of a base, preferably a secondary or uerriary base.
Type:
Grant
Filed:
November 28, 2001
Date of Patent:
January 6, 2004
Assignee:
Deutsches Krebsforschungszentrum Stiftung des
öffentlichen Rechts
Inventors:
Markus Beier, Stefan Matysiak, Jorg Hoheisel
Abstract: The present invention relates to peptides suited for inhibiting HPV-E6 proteins, DNAs encoding them and the use of both, particularly for eliminating HPV tumor cells.
Type:
Grant
Filed:
October 4, 2001
Date of Patent:
August 26, 2003
Assignee:
Deutsches Krebsforschungszentrum Stiftung des Oeffentlichen
Rechts
Abstract: A method for detecting an element in a sample using a transmission electron microscope to measure a first image of the intensities of the sample at an energy loss in the range of the element signal. The background at various points is determined in a comparator sample which does not contain the element intensity. Energy loss is determined at the front of the element signal, and an energy loss is determined in the range of the element signal. From these values an approximation function is calculated so that an image of the pure element-specific intensities can be calculated.
Type:
Grant
Filed:
January 3, 2000
Date of Patent:
July 1, 2003
Assignee:
Deutsches Krebsforschungszentrum Stiftung des
Öffentlichen Rechts
Abstract: The intention is to provide a process for the contrast enhancement of a specific particle in an image of a specimen, taken by a transmission electron microscope, in which a calculated contrast-rich image is created by way of the background intensities calculated from the intensities of a first image being drawn off pixel by pixel, whereby the background intensities are calculated as a function of the intensities of a second image. In this situation, it is intended that this process should feature a higher range of application than processes known hitherto, and, in particular, are well-suited for contrast enhancement for gold particles in immuno-gold marking.
Type:
Grant
Filed:
October 27, 2000
Date of Patent:
May 13, 2003
Assignee:
Deutsches Krebsforschungszentrum Stiftung Des
Öffentlichen Rechts
Inventors:
Ansgar Haking, Helmut Tröster, Karsten Richter, Michael Trendelenburg
Abstract: The present invention relates to a conjugate comprising an active substance and a compound having a binding site for metallic compounds. In addition, this invention relates to a process for the preparation of such a conjugate and its use.
Type:
Grant
Filed:
February 9, 1998
Date of Patent:
June 25, 2002
Assignee:
Deutsches Krebsforschungszentrum Stiftung Des
Öffentlichen Rechts
Inventors:
Hannsjörg Sinn, Wolfgang Maier-Borst, Hans-Hermann Schrenk, Gerd Stehle
Abstract: A phagemid has been constructed that expresses an antibody fused to coliphage pIII protein. The phagemid is suitable for selecting specific antibodies from large gene libraries with small quantities of antigen. The antibody-pIII gene can be strongly repressed, so that it allows antibody libraries to be amplified without the danger of deletion mutants predominating. After induction, large quantities of the fusion protein may be expressed.
Type:
Grant
Filed:
August 25, 2000
Date of Patent:
May 14, 2002
Assignee:
Deutsches Krebsforschungszentrum Stiftung des
öffentlichen Rechts
Inventors:
Frank Breitling, Melvyn Little, Stefan Dübel, Michael Braunagel, Iris Klewinghaus
Abstract: This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein. Moreover, this invention deals with a papilloma virus genome containing such a DNA. Furthermore, this invention concerns proteins coded by the papilloma virus genome and virus-like particles as well as antibodies directed thereagainst and the use thereof for diagnosis, treatment and vaccination.
Type:
Grant
Filed:
May 25, 2000
Date of Patent:
April 9, 2002
Assignee:
Deutsches Krebsforschungszentrum Stiftung des
Öffentlichen Rechts
Inventors:
Vladimir Shamanin, Ethel-Michele De Villiers-Zur Hausen, Harald Zur Hausen
Abstract: The present invention relates to a preparation comprising a substance influencing the cellular redox state for treating papilloma virus-positive malignant lesions.
Type:
Grant
Filed:
September 4, 1997
Date of Patent:
May 29, 2001
Assignee:
Deutsches Krebsforschungszentrum Stiftung Des
Öffentlichen Rechts
Abstract: A device for simultaneously or sequentially carrying out chemical reactions ncludes a stack of four rods; and a carrier plate which is displaceable. The stack of four rods is composed of a first rod which has a position which is fixed and which has a plurality of throughgoing bores defined therein; a second rod which is in contact with the first rod, which is fixedly connected to the carrier plate so that the second rod is displaceable, and which has a throughgoing bore defined therethrough; a third rod which is in contact with the second rod, which is disposed so that it is displaceable by the carrier plate, arid which has defined therein a plurality of reaction chambers which are provided with two openings located opposite one another and which are present in a number n; and a fourth rod which is in contact with the third rod, which is fixedly connected to the carrier plate, and which has a throughgoing bore defined therein.
Type:
Grant
Filed:
August 31, 1994
Date of Patent:
July 23, 1996
Assignee:
Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts