Patents Assigned to Devgen NV
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Publication number: 20120297501Abstract: The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. The invention provides transgenic plants that (i) express or are capable of expressing interfering RNAs of the invention and (ii) are resistant to infestation by insect pest species.Type: ApplicationFiled: May 2, 2012Publication date: November 22, 2012Applicant: Devgen NVInventors: Myriam Beghyn, Thierry Andre Olivier Eddy Bogaert, Pascale Feldmann, Romaan Raemaekers
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Publication number: 20120137387Abstract: The present invention relates to control of pest infestation by inhibiting one or more biological functions. The invention provides methods and compositions for such control, By feeding one or more recombinant double stranded RNA molecules provided by the invention to the pest, a reduction in pest infestation is obtained through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.Type: ApplicationFiled: December 20, 2010Publication date: May 31, 2012Applicants: DevGen NV, Monsanto Technology LLCInventors: James A. Baum, Claire A. Cajacob, Pascale Feldmann, Gregory R. Heck, Irene Nooren, Geert Plaetinck, Wendy Maddelein, Ty T. Vaughn
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Patent number: 8114980Abstract: There is provided a method of identifying DNA responsible for conferring a particular phenotype in a cell which method comprises a) constructing a cDNA or genomic library of the DNA of the cell in a suitable vector in an orientation relative to a promoter(s) capable of initiating transcription of the cDNA or DNA to double stranded (ds) RNA upon binding of an appropriate transcription factor to the promoter(s), b) introducing the library into one or more of the cells comprising the transcription factor, and c) identifying and isolating a particular phenotype of the cell comprising the library and identifying the DNA or cDNA fragment from the library responsible for conferring the phenotype.Type: GrantFiled: April 16, 2004Date of Patent: February 14, 2012Assignee: Devgen NVInventors: Geert Plaetinck, Christ Platteeuw, Katharine Mortier, Thierry Bogaert
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Patent number: 7932062Abstract: Improved vector constructs useful in the expression of double-stranded RNA are provided. The constructs are particularly useful for expression of double-stranded RNA in vitro and in vivo.Type: GrantFiled: March 26, 2008Date of Patent: April 26, 2011Assignee: Devgen NVInventors: Geert Karel Maria Plaetinck, Jean-Pierre Renard, Thierry Andre Oliver Eddy Bogaert
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Publication number: 20100170000Abstract: The present invention concerns concatemer and/or stabilized RNA constructs capable of forming dsRNA, optionally comprising a sequence capable of protecting the dsRNA against RNA processing in a host cell. The invention also relates to methods of producing these constructs and to methods for using these constructs. The constructs according to the present invention are particularly useful in plant pest control.Type: ApplicationFiled: October 25, 2005Publication date: July 1, 2010Applicant: DEVGEN NVInventors: Marc Van De Craen, Geert Karel Maria Plaetinck, Isabelle Vercauteren, Marc Georges Logghe, Thierry Andre Olivier Eddy Bogaert, Richard Zwaal
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Publication number: 20100168102Abstract: The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula (I) or (II) or a stereoisomer tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, wherein Ar1, Ar2, R1, R3, p and n have the meaning defined in the claims In particular, the present invention relates to more specifically AGC kinases inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.Type: ApplicationFiled: July 11, 2006Publication date: July 1, 2010Applicant: Devgen NVInventors: Olivier Raynald Defert, Gert De Wilde, Petra Blom, Dirk Casimir Maria Leysen, Thomas Brown, Nadzeya Kaval
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Publication number: 20090285784Abstract: The present invention concerns methods for controlling insect infestation via RNAi-mediated gene silencing, whereby the intact insect cell(s) are contacted with a double-stranded RNA from outside the insect cell(s) and whereby the double-stranded RNA is taken up by the intact insect cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from insect pests. Alternatively, the methods are used for treating and/or preventing insect infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable insect target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.Type: ApplicationFiled: January 12, 2007Publication date: November 19, 2009Applicant: Devgen NVInventors: Romaan Raemaekers, Laurent Kubler, Geert Karel Maria Plaetinck, Els Vanbleu
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Publication number: 20090263364Abstract: The present invention relates in generally to RNAi and its use in gene silencing. In particular, the present invention relates to methods and constructs for delivering double stranded RNA (dsRNA) to pest organisms.Type: ApplicationFiled: October 25, 2005Publication date: October 22, 2009Applicant: Devgen NVInventors: Thierry Andre Olivier Eddy Bogaert, Richard Zwaal, Geert Plaetinck, Jan Octaaf De Kerpel, Titus Jan Kaletta
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Publication number: 20090233960Abstract: The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula I, II, or III or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, I II III wherein X, R1, R2, R3, R31, n, and m have the meaning defined in the claims. In particular, the present invention relates more specifically to ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.Type: ApplicationFiled: October 13, 2006Publication date: September 17, 2009Applicant: Devgen NVInventors: Philippe Van Rompaey, Philippe Arzel, Olivier Raynald Defert, Dirk Casimir Maria Leysen
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Publication number: 20090126038Abstract: The present invention concerns concatemer and/or stabilized RNA constructs capable of forming dsRNA, optionally comprising a sequence capable of protecting the dsRNA against RNA processing in a host cell. The invention also relates to methods of producing these constructs and to methods for using these constructs. The constructs according to the present invention are particularly useful in plant pest control.Type: ApplicationFiled: October 25, 2005Publication date: May 14, 2009Applicant: DEVGEN NVInventors: Marc Van De Craen, Geert Karel Maria Plaetinck, Isabelle Vercauteren, Marc Georges Logghe, Thierry Andre Olivier Eddy Bogaert, Richard Zwaal
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Publication number: 20090118283Abstract: The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula (I) or (II) or a stereoisomer tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, wherein Ar1, Ar2, R1, R3, p and n have the meaning defined in the claims In particular, the present invention relates to more specifically AGC kinases inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.Type: ApplicationFiled: July 11, 2006Publication date: May 7, 2009Applicant: Devgen NVInventors: Olivier Raynald Defert, Gert De Wilde, Petra Blom, Dirk Casimir Maria Leysen, Thomas Brown, Nadzeya Kaval
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Publication number: 20080146445Abstract: The present invention concerns nematicidal compounds, their formulation as nematicidal composition and their use for controlling nematodes, preferably plant parasitic nematodes.Type: ApplicationFiled: December 16, 2005Publication date: June 19, 2008Applicant: Devgen NVInventors: Jan Octaaf De Kerpel, Dirk Leysen
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Publication number: 20080125432Abstract: The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula having the structural Formula I, II, III or IV, stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, wherein X, Y1, Y2, R1, n, R3, R8, R9, R10, L1, L2, Ar1 and Ar2 are defined in claim 1. The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.Type: ApplicationFiled: December 1, 2005Publication date: May 29, 2008Applicant: Devgen NVInventors: Petra Blom, Jan Octaaf De Kerpel, Eric Pierre Paul Rene Fourmaintraux, Titus Jan Kaletta, Dirk Leysen
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Publication number: 20080039442Abstract: The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula (I), (II), (III) or (IV), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, Formula (I), (II), (III), (IV), wherein X1, X2, Y, Z, W, R1, R8, R9, R10, L, A, z, and n have the meaning defined in claim 1. The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.Type: ApplicationFiled: December 20, 2005Publication date: February 14, 2008Applicant: Devgen NVInventors: Petra Blom, Jan de Kerpel, Eric Fourmaintraux, Titus Kaletta, Dirk Leysen
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Publication number: 20070092910Abstract: The present invention relates to nucleotide sequences, particularly those of SEQ ID NO's 2, 7 and 9 that encode and may be used to express amino acid sequences that are useful in the identification and development of compounds for the prevention and treatment of metabolic diseases such as diabetes and obesity. The invention also relates to the amino acid sequences—such as proteins and/or polypeptides—that are encoded by, and that may be obtained by suitable expression of, the nucleotide sequences of the invention, particularly those set out in SEQ ID NO's 1, 6 and 8. The invention further relates to genetic constructs, host cells and organisms that have been transformed with the nucleotide sequences of the invention and that can express the amino acid sequences of the invention and methods and compositions which utilize the nucleotide and amino acid sequences of the invention.Type: ApplicationFiled: June 17, 2004Publication date: April 26, 2007Applicant: Devgen NVInventors: Gert De Wilde, Michael Saunders, Marc Logghe
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Publication number: 20060275767Abstract: The present invention relates to nucleotide sequences that encode and may be used to express amino acid sequences that are useful in the identification and development of compounds with activity as pharmaceuticals, in particular of compounds for the prevention and treatment of metabolic diseases such as diabetes and obesity. The invention also relates to the amino acid sequences—such as proteins and polypeptides—that are encoded by, and that may be obtained by suitable expression of, the nucleotide sequences of the invention, particularly the amino acid sequences of JIK, PSK, TAO1 and Q9P2I6. The invention also relates to various uses and modulators of, and methods incorporating, the nucleotide and amino acid sequences of the invention.Type: ApplicationFiled: December 19, 2003Publication date: December 7, 2006Applicant: Devgen NVInventor: Gert Jules De Wilde
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Patent number: 7083947Abstract: Improved techniques for performing assays using nematode worms, such as nematode worms from the genus Caenorhabditis. The assays generally comprise exposing nematodes to at least one compound which paralyzes or kills the nematodes.Type: GrantFiled: May 21, 2001Date of Patent: August 1, 2006Assignee: Devgen NVInventors: Philippe Verwaerde, Gwladys Cuvillier
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Patent number: 7030290Abstract: The invention provides methods of screening compounds for potential pharmacological activity using nematode worms, principally but not exclusively the nematode C. elegans. Specifically, the invention relates to the use of nematodes modified to have certain characteristics which provide advantages for compound screening, such as constitutive pharyngeal pumping, increased gut permeability or altered gut molecular transport. Methods for selecting suitably modified nematodes from a population of nematodes are also provided.Type: GrantFiled: August 11, 2003Date of Patent: April 18, 2006Assignee: Devgen NVInventors: Philippe Verwaerde, Richard Feichtinger, Myriam Behgyn, Thierry Bogaert
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Patent number: 7005423Abstract: There is provided a method of identifying DNA responsible for conferring a particular phenotype in a cell which method comprises a) constructing a cDNA or genomic library of the DNA of the cell in a suitable vector in an orientation relative to a promoter(s) capable of initiating transcription of the cDNA or DNA to double stranded (ds) RNA upon binding of an appropriate transcription factor to the promoter(s), b) introducing said library into one or more of the cells comprising the transcription factor, and c) identifying and isolating a particular phenotype of the cell comprising the library and identifying the DNA or cDNA fragment from the library responsible for conferring the phenotype.Type: GrantFiled: July 2, 1999Date of Patent: February 28, 2006Assignee: Devgen NVInventors: Geert Plaetinck, Christ Platteeuw, Katherine Mortier, Thierry Bogart
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Publication number: 20050229260Abstract: The invention is concerned with use of the model organism C. elegans as a research tool to screen for compounds active in insulin signalling. In particular, the invention relates to improved screening methods based on release of C. elegans from the dauer larval state.Type: ApplicationFiled: June 8, 2001Publication date: October 13, 2005Applicant: DevGen NVInventors: Richard Feichtinger, Thierry Bogaert