Abstract: The invention includes the use of the HE/HE4a markers to assess ovarian cancer in a subject. Included also are compositions and methods of using HE/HE4a marker for diagnosis, grading and staging of ovarian cancers, determining prognosis and treatment effectiveness of a subject who has been diagnosed with ovarian cancer.
Type:
Application
Filed:
July 1, 2020
Publication date:
October 15, 2020
Applicants:
PACIFIC NORTHWEST DIABETES RESEARCH INSTITUTE, FUJIREBIO DIAGNOSTICS, INC.
Inventors:
Ingegerd HELLSTROM, Karl-Erik HELLSTROM, John RAYCRAFT, Christian FERMÉR, Eva RÖIJER
Abstract: Systems and methods that facilitate genetic research are described. The systems and methods can utilize (1) fluorescent dyes to sort tetrads from vegetative cells, dyads and dead cells; (2) natural genetic sequences to capture tetrad relationships of recombinant progeny; and (3) markers in parental organisms to identify genetic recombination events in genomic regions of interest.
Type:
Application
Filed:
July 14, 2017
Publication date:
August 29, 2019
Applicant:
PACIFIC NORTHWEST DIABETES RESEARCH INSTITUTE
Inventors:
Aimée M. Dudley, Gareth Cromie, Amy Sirr, Nikita Sakhanenko
Abstract: The invention includes the use of the HE/HE4a markers to assess ovarian cancer in a subject. Included also are compositions and methods of using HE/HE4a marker for diagnosis, grading and staging of ovarian cancers, determining prognosis and treatment effectiveness of a subject who has been diagnosed with ovarian cancer.
Type:
Application
Filed:
October 19, 2017
Publication date:
March 1, 2018
Applicants:
PACIFIC NORTHWEST DIABETES RESEARCH INSTITUTE, FUJIREBIO DIAGNOSTICS, INC.
Inventors:
Ingegerd HELLSTROM, Karl-Erik HELLSTROM, John RAYCRAFT, Christian FERMÉR, Eva RÖIJER
Abstract: The invention includes the use of the HE/HE4a markers to assess ovarian cancer in a subject. Included also are compositions and methods of using HE/HE4a marker for diagnosis, grading and staging of ovarian cancers, determining prognosis and treatment effectiveness of a subject who has been diagnosed with ovarian cancer.
Type:
Grant
Filed:
February 17, 2011
Date of Patent:
November 21, 2017
Assignees:
PACIFIC NORTHWEST DIABETES RESEARCH INSTITUTE, FUJIREBIO DIAGNOSTICS, INC.
Inventors:
Ingegerd Hellstrom, Karl-Erik Hellstrom, John Raycraft, Christian Fermér, Eva Roijer
Abstract: A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem cells, hepatic stem cells, pancreatic stem cells or their descendants, committed progenitor cells, from healthy tissue of the patient or of the biliary tree of a non-autologous donor and engrafting the cells into the wall of bile ducts near to the organ to be treated. The graft consists of stem cells or progenitors that are admixed with biomaterials and, optionally, with cytokines and/or native epithelial-mesenchymal cells appropriate for the maturational lineage stage of the cells to be engrafted.
Type:
Grant
Filed:
November 9, 2015
Date of Patent:
September 5, 2017
Assignees:
The University of North Carolina at Chapel Hill, University of Miami-Diabetes Research Institute, Sapienza Università Di Roma
Inventors:
Lola M. Reid, Yunfang Wang, David A. Gerber, Giacomo Lanzoni, Luca Inverardi, Juan Dominguez-Bendala, Domenico Alvaro, Vincenzo Cardinale, Eugenio Gaudio, Guido Carpino
Abstract: A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem cells, hepatic stem cells, pancreatic stem cells or their descendants, committed progenitor cells, from healthy tissue of the patient or of the biliary tree of a non-autologous donor and engrafting the cells into the wall of bile ducts near to the organ to be treated. The graft consists of stem cells or progenitors that are admixed with biomaterials and, optionally, with cytokines and/or native epithelial-mesenchymal cells appropriate for the maturational lineage stage of the cells to be engrafted.
Type:
Application
Filed:
March 12, 2014
Publication date:
October 9, 2014
Applicants:
University of North Carolina at Chapel Hill, Sapienza Università di Roma, Diabetes Research Institute
Inventors:
Lola M. REID, Yunfang WANG, David A. GERBER, Giacomo LANZONI, Luca INVERARDI, Juan DOMINGUEZ-BENDALA, Domenico ALVARO, Vincenzo CARDINALE, Eugenio GAUDIO, Guido CARPINO
Abstract: A method, computer implemented method and associated apparatus for the management of diabetes comprises utilizing zone model predictive control (Zone-MPC) to control delivery of an insulin or insulin analog within a zone of desired values.
Type:
Grant
Filed:
February 11, 2011
Date of Patent:
June 24, 2014
Assignees:
Regents of the University of California, Sansum Diabetes Research Institute
Inventors:
Francis J. Doyle, III, Benyamin Grosman, Eyal Dassau, Lois Javanovic, Howard Zisser
Abstract: Disclosed and claimed are: a composition including at least one glycosaminoglycan, e.g., CIS, at least one perfluorinated substance and at least one alginate, e.g., sodium alginate, wherein:
the at least one glycosaminoglycan and/or the perfluorinated substance and/or the alginate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt; or
the at least one glycosaminoglycan, the perfluorinated substance and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS; or
the at least one glycosaminoglycan and/or the perfluorinated substance and/or the alginate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt, and the at least one glycosaminoglycan and the alginate are covalently bound, e.g.
Type:
Grant
Filed:
January 4, 2000
Date of Patent:
October 7, 2003
Assignees:
Biomm, Inc., Diabetes Research Institute, University of Miami
Inventors:
Christopher Fraker, Luca Inverardi, Marcos Mares-Guia, Camillo Ricordi