Patents Assigned to Diffusion Pharmaceuticals LLC
  • Oral formulations of bipolar trans carotenoids
    Patent number: 11491129
    Abstract: The subject invention relates to a variety of formulations of bipolar trans carotenoids including pharmaceutical compositions for oral delivery of a bipolar trans carotenoid comprising i) a bipolar trans carotenoid, ii) a cyclodextrin, and iii) a coating. The invention also relates to preparation of such formulations and their uses.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: November 8, 2022
    Assignee: DIFFUSION PHARMACEUTICALS LLC
    Inventors: John L. Gainer, Robert Murray
  • Trans carotenoids, their synthesis, formulation and uses
    Patent number: 11278621
    Abstract: The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: March 22, 2022
    Assignee: DIFFUSION PHARMACEUTICALS LLC
    Inventors: John L. Gainer, Marc Lanz
  • Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
    Patent number: 11185523
    Abstract: The subject disclosure relates to compounds and compositions including chemotherapy agents and/or radiation therapy with bipolar trans carotenoids, and the use of such compounds for the treatment of various cancers including pancreatic and brain cancers.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: November 30, 2021
    Assignee: DIFFUSION PHARMACEUTICALS LLC
    Inventor: John L. Gainer
  • Diffusion enhancing compounds and their use alone or with thrombolytics
    Patent number: 11147859
    Abstract: The subject invention relates to diffusion enhancing compounds and their use alone or with thrombolytic agents for the treatment of disorders resulting from the formation of a thrombus such as a myocardial infarction or stroke.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: October 19, 2021
    Assignee: DIFFUSION PHARMACEUTICALS LLC
    Inventor: John L. Gainer
  • DIFFUSION ENHANCING COMPOUNDS AND THEIR USE WITH THROMBECTOMY AND EMBOLECTOMY AND OTHER VASCULAR DISEASE PROCEDURES
    Publication number: 20210244698
    Abstract: The subject invention relates to novel methods for the rapid treatment of disorders resulting from thrombosis or embolism such as a myocardial infraction or stroke. Specifically, the invention relates to diffusion enhancing compounds and their use with embolectomy and thrombectomy, or other procedures for the treatment of ischemia.
    Type: Application
    Filed: July 30, 2019
    Publication date: August 12, 2021
    Applicant: DIFFUSION PHARMACEUTICALS LLC
    Inventors: David G. KALERGIS, Thomas BYRNE
  • DIFFUSION ENHANCING COMPOUNDS AND THEIR USE ALONE OR WITH THROMBOLYTICS
    Publication number: 20190083584
    Abstract: The subject invention relates to diffusion enhancing compounds and their use alone or with thrombolytic agents for the treatment of disorders resulting from the formation of a thrombus such as a myocardial infarction or stroke.
    Type: Application
    Filed: November 16, 2018
    Publication date: March 21, 2019
    Applicant: DIFFUSION PHARMACEUTICALS LLC
    Inventor: John L. GAINER
  • ORAL FORMULATIONS OF BIPOLAR TRANS CAROTENOIDS
    Publication number: 20190038586
    Abstract: The subject invention relates to a variety of formulations of bipolar trans carotenoids including pharmaceutical compositions for oral delivery of a bipolar trans carotenoid comprising i) a bipolar trans carotenoid, ii) a cyclodextrin, and iii) a coating. The invention also relates to preparation of such formulations and their uses.
    Type: Application
    Filed: July 9, 2018
    Publication date: February 7, 2019
    Applicant: Diffusion Pharmaceuticals LLC
    Inventors: John L. GAINER, Robert MURRAY
  • Diffusion enhancing compounds and their use alone or with thrombolytics
    Patent number: 10130689
    Abstract: The subject invention relates to diffusion enhancing compounds and their use alone or with thrombolytic agents for the treatment of disorders resulting from the formation of a thrombus such as a myocardial infarction or stroke.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: November 20, 2018
    Assignee: DIFFUSION PHARMACEUTICALS LLC
    Inventor: John L. Gainer
  • TRANS CAROTENOIDS, THEIR SYNTHESIS, FORMULATION AND USES
    Publication number: 20180271979
    Abstract: The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.
    Type: Application
    Filed: March 20, 2018
    Publication date: September 27, 2018
    Applicant: Diffusion Pharmaceuticals LLC
    Inventors: John L. GAINER, Marc LANZ
  • Oral formulations of bipolar trans carotenoids
    Patent number: 10016384
    Abstract: The subject invention relates to a variety of formulations of bipolar trans carotenoids including pharmaceutical compositions for oral delivery of a bipolar trans carotenoid comprising i) a bipolar trans carotenoid, ii) a cyclodextrin, and iii) a coating. The invention also relates to preparation of such formulations and their uses.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: July 10, 2018
    Assignee: DIFFUSION PHARMACEUTICALS LLC
    Inventors: John L. Gainer, Robert Murray
  • Trans carotenoids, their synthesis, formulation and uses
    Patent number: 9950067
    Abstract: The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: April 24, 2018
    Assignee: Diffusion Pharmaceuticals, LLC
    Inventors: John L. Gainer, Marc Lanz
  • BIPOLAR TRANS CARTENOID SALTS AND THEIR USES
    Publication number: 20170202798
    Abstract: The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.
    Type: Application
    Filed: January 30, 2017
    Publication date: July 20, 2017
    Applicant: DIFFUSION PHARMACEUTICALS LLC
    Inventors: John L. GAINER, Raymond C. GRABIAK
  • Bipolar trans carotenoid salts and their uses
    Patent number: 9604899
    Abstract: The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: March 28, 2017
    Assignee: Diffusion Pharmaceuticals LLC
    Inventors: John L. Gainer, Raymond C. Grabiak
  • Oral formulations of bipolar trans carotenoids
    Patent number: 8974822
    Abstract: The subject invention relates to a variety of formulations of bipolar trans carotenoids including pharmaceutical compositions for oral delivery of a bipolar trans carotenoid comprising i) a bipolar trans carotenoid, ii) a cyclodextrin, and iii) a coating. The invention also relates to preparation of such formulations and their uses.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: March 10, 2015
    Assignee: Diffusion Pharmaceuticals LLC
    Inventors: John L. Gainer, Robert Murray
  • Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
    Patent number: 8901174
    Abstract: The subject application relates to methods of treatment of peripheral vascular disease (PVD) as well as ischemic osteonecrosis, peritoneal ischemia, chronic ocular disease, macular degeneration, or diabetic retinopathy, comprising administering a therapeutically effective amount of a trans carotenoid. The invention also relates to the use of such carotenoids as pretreatments for mammals at risk of an ischemic event.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: December 2, 2014
    Assignee: Diffusion Pharmaceuticals LLC
    Inventor: John L. Gainer
  • New class of therapeutics that enhance small molecule diffusion
    Publication number: 20130018014
    Abstract: The subject application relates to novel compositions containing a diffusion enhancing compound and their use in treating a variety of disorders.
    Type: Application
    Filed: June 22, 2012
    Publication date: January 17, 2013
    Applicant: Diffusion Pharmaceuticals LLC
    Inventor: John L. Gainer
  • Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
    Patent number: 8293804
    Abstract: The subject application relates to methods of treatment of peripheral vascular disease (PVD) as well as ischemic osteonecrosis, peritoneal ischemia, chronic ocular disease, macular degeneration, or diabetic retinopathy, comprising administering a therapeutically effective amount of a trans carotenoid. The invention also relates to the use of such carotenoids as pretreatments for mammals at risk of an ischemic event.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: October 23, 2012
    Assignee: Diffusion Pharmaceuticals LLC
    Inventor: John L. Gainer
  • Bipolar trans carotenoid salts and their uses
    Patent number: 8269027
    Abstract: The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: September 18, 2012
    Assignee: Diffusion Pharmaceuticals LLC
    Inventors: John L. Gainer, Raymond C. Grabiak
  • Class of therapeutics that enhance small molecule diffusion
    Patent number: 8206751
    Abstract: The subject invention relates to novel compositions containing a diffusion enhancing compound and their use in treating a variety of disorders.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: June 26, 2012
    Assignee: Diffusion Pharmaceuticals LLC
    Inventor: John L. Gainer
  • Trans carotenoids, their synthesis, formulation and uses
    Publication number: 20120095099
    Abstract: The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.
    Type: Application
    Filed: August 5, 2011
    Publication date: April 19, 2012
    Applicant: Diffusion Pharmaceuticals LLC
    Inventors: John L. Gainer, Marc Lanz