Patents Assigned to DIFUSION TECHNOLOGIES, INC.
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Patent number: 9492584Abstract: Methods of post-loading ceramic particles with antimicrobial metal cations are disclosed. In certain embodiments, the post-loaded particles are zeolites, wherein the zeolites have been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer such as polyaryletheretherketone (PEEK). In certain embodiments, the source of antimicrobial activity includes ion-exchangeable cations contained in a zeolite. In certain embodiments, disclosed are methods of imparting antimicrobial activity to devices by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in the device.Type: GrantFiled: November 24, 2010Date of Patent: November 15, 2016Assignee: DiFusion Technologies, Inc.Inventors: Joseph J. Crudden, Derrick Johns
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Patent number: 9375321Abstract: Devices such as orthopedic implants are composed of a thermoplastic resin such as polyaryletheretherketone (PEEK), and include a ceramic species, such as a zeolite, to enhance its hydrophilic properties. The ceramic species can be a surface coating, can be incorporated or embedded into the thermoplastic resin, or can be both a surface coating and incorporated or embedded into the resin. In certain embodiments, the ceramic species is zeolite that is incorporated into the device, especially at the exposed surface of the device, and is devoid of antimicrobial metal ions. The device is introduced into the body surgically.Type: GrantFiled: August 11, 2015Date of Patent: June 28, 2016Assignee: DiFusion Technologies, Inc.Inventors: Peter Whang, Joseph Crudden, Derrick W. Johns
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Patent number: 9132576Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.Type: GrantFiled: August 28, 2014Date of Patent: September 15, 2015Assignee: DiFusion Technologies, Inc.Inventors: Joseph J. Crudden, Derrick Johns
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Patent number: 9107765Abstract: Devices such as orthopedic implants are composed of a thermoplastic resin such as polyaryletheretherketone (PEEK), and include a ceramic species, such as a zeolite, to enhance its hydrophilic properties. The ceramic species can be a surface coating, can be incorporated or embedded into the thermoplastic resin, or can be both a surface coating and incorporated or embedded into the resin. In certain embodiments, the ceramic species is zeolite that is incorporated into the device, especially at the exposed surface of the device, and is devoid of antimicrobial metal ions. The device is introduced into the body surgically.Type: GrantFiled: May 6, 2011Date of Patent: August 18, 2015Assignee: DiFusion Technologies, Inc.Inventors: Gary Ghiselli, Peter Whang, Jami Hafiz, Joseph Crudden, Derrick W. Johns
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Patent number: 8840914Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.Type: GrantFiled: October 17, 2012Date of Patent: September 23, 2014Assignee: DiFusion Technologies, Inc.Inventors: Joseph J. Crudden, Jami Hafiz, James E. Deaton, John R. Pepper, Derrick Johns
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Patent number: 8821912Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.Type: GrantFiled: December 10, 2010Date of Patent: September 2, 2014Assignee: DiFusion Technologies, Inc.Inventors: Joseph J. Crudden, Jami Hafiz, James E. Deaton, John R. Pepper, Derrick Johns
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Publication number: 20130073042Abstract: Devices such as orthopedic implants are composed of a thermoplastic resin such as polyaryletheretherketone (PEEK), and include a ceramic species, such as a zeolite, to enhance its hydrophilic properties. The ceramic species can be a surface coating, can be incorporated or embedded into the thermoplastic resin, or can be both a surface coating and incorporated or embedded into the resin. In certain embodiments, the ceramic species is zeolite that is incorporated into the device, especially at the exposed surface of the device, and is devoid of antimicrobial metal ions. The device is introduced into the body surgically.Type: ApplicationFiled: May 6, 2011Publication date: March 21, 2013Applicant: DIFUSION TECHNOLOGIES, INC.Inventors: Gary Ghiselli, Peter Whang, Jami Hafiz, Joseph Crudden, Derrick W. Johns
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Publication number: 20130037991Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.Type: ApplicationFiled: October 17, 2012Publication date: February 14, 2013Applicant: DIFUSION TECHNOLOGIES, INC.Inventor: DiFusion Technologies, Inc.
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Publication number: 20130004585Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.Type: ApplicationFiled: December 10, 2010Publication date: January 3, 2013Applicant: DIFUSION TECHNOLOGIES, INC.Inventors: Joseph J. Crudden, Jami Hafiz, James E. Deaton, John R. Pepper, Derrick Johns
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Publication number: 20120315340Abstract: Methods of post-loading ceramic particles with antimicrobial metal cations are disclosed. In certain embodiments, the post-loaded particles are zeolites, wherein the zeolites have been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer such as polyaryletheretherketone (PEEK). In certain embodiments, the source of antimicrobial activity includes ion-exchangeable cations contained in a zeolite. In certain embodiments, disclosed are methods of imparting antimicrobial activity to devices by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in the device.Type: ApplicationFiled: November 24, 2010Publication date: December 13, 2012Applicant: DIFUSION TECHNOLOGIES, INC.Inventors: Joseph J. Crudden, Derrick Johns
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Publication number: 20120141599Abstract: Medical implants such as bone graft substitutes that include one or more cations are delivered in a local environment to promote osteogenesis. Zeolite loaded with a metal cation in combination with an implant such as a bone graft substitute can be used as an implant in the body to regulate protein transcription and translation. Also disclosed are methods of promoting osteogenesis in a patient in need thereof, methods for modulating bone formation and mineralization by implanting in a patient a medical implant comprising ion-exchangeable cations, and methods of regulating BMP gene expression in bone cells in a patient by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in a bone substitute implanted in a patient so that BMP gene expression can be upregulated or downregulated appropriately.Type: ApplicationFiled: March 30, 2010Publication date: June 7, 2012Applicant: DIFUSION TECHNOLOGIES, INC.Inventors: Derrick Johns, Matthew Geck, Peter Whang, Jami Hafiz