Patents Assigned to Digene Diagnostics, Incorporated
  • Bifunctional DNA-protein conjugating agent
    Patent number: 4873187
    Abstract: A cationic detergent having a positively charged group and a hydrophobic group is used to conjugate an enzymatically active enzyme molecule with a single-stranded nucleic acid molecule. The conjugate may be used to detect the presence of nucleic acid molecules having a nucleotide sequence which is complementary to that of the single-stranded molecule of the conjugate.
    Type: Grant
    Filed: March 13, 1986
    Date of Patent: October 10, 1989
    Assignee: Digene Diagnostics, Incorporated
    Inventor: Floyd Taub
  • Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
    Patent number: 4820630
    Abstract: Lesions in genetic sequences, for example, the sickle cell anemia mutation in the beta globin gene, are detected by means of interactive labels in a nucleic acid hybridization assay. A signal is generated only if the labels are in physical proximity which is made dependent on whether a predetermined normal or abnormal sequence is present by exposure to appropriate conditions such as restriction enzyme digestion or stringent hybridization.
    Type: Grant
    Filed: November 23, 1984
    Date of Patent: April 11, 1989
    Assignee: Digene Diagnostics, Incorporated
    Inventor: Floyd Taub