Patents Assigned to DiPharma S.A.
  • Stable solid pharmaceutical formulations containing 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cylcohexanedione
    Patent number: 10888527
    Abstract: The present invention relates to highly stable drug dosage forms comprising. The invention also contemplates said highly stable drug dosage forms for the treatment of diseases where inhibition of 4-hydroxyphenylpyruvate dioxygenase 5 will result at improving the health of the patient.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: January 12, 2021
    Assignee: DIPHARMA S.A.
    Inventors: Chiara Conti, Salvatore Agostino Giammillari, Giuseppe Maccari
  • Stable Solid Pharmaceutical Formulations Containing 2-(2-Nitro-4-Trifluoromethylbenzoyl)-1,3-Cylcohexanedione
    Publication number: 20190160014
    Abstract: The present invention relates to highly stable drug dosage forms comprising. The invention also contemplates said highly stable drug dosage forms for the treatment of diseases where inhibition of 4-hydroxyphenylpyruvate dioxygenase 5 will result at improving the health of the patient.
    Type: Application
    Filed: February 9, 2017
    Publication date: May 30, 2019
    Applicant: Dipharma S.A.
    Inventors: Chiara CONTI, Salvatore Agostino GIAMMILLARI, Giuseppe MACCARI
  • Crystalline inhibitor of 4-hydroxyphenylpyruvate dioxygenase
    Patent number: 10093610
    Abstract: The present invention relates to an improved synthesis and crystallization process of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, also known as nitisinone or NTBC.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: October 9, 2018
    Assignee: DIPHARMA S.A.
    Inventor: Emanuele Attolino
  • Crystalline Inhibitor of 4-Hydroxyphenylpyruvate Dioxygenase
    Publication number: 20180148402
    Abstract: The present invention relates to an improved synthesis and crystallization process of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, also known as nitisinone or NTBC.
    Type: Application
    Filed: September 14, 2017
    Publication date: May 31, 2018
    Applicant: Dipharma S.A.
    Inventor: Emanuele ATTOLINO
  • Crystalline inhibitor of 4-hydroxyphenylpyruvate dioxygenase, and a process of synthesis and crystallization thereof
    Patent number: 9783485
    Abstract: The present invention relates to an improved synthesis and crystallization process of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, also known as nitisinone or NTBC.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: October 10, 2017
    Assignee: Dipharma S.A.
    Inventor: Emanuele Attolino
  • Stable compositions of tetrahydrobiopterin
    Patent number: 9492451
    Abstract: The present invention relates to stable pharmaceutical compositions of tetrahydrobiopterin and processes for producing such compositions. Particularly the present invention relates to stable pharmaceutical compositions comprising tetrahydrobiopterin and at least one stabilizing agent.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: November 15, 2016
    Assignee: DiPharma S.A.
    Inventors: Maharukh Tehmasp Rustomjee, Anilkumar Surendrakumar Gandhi
  • PROCESS FOR THE PREPARATION OF (R)-PRAMIPEXOLE
    Publication number: 20120253047
    Abstract: The invention relates to a novel process for the preparation of (R)-2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole, or a salt thereof.
    Type: Application
    Filed: April 19, 2012
    Publication date: October 4, 2012
    Applicant: Dipharma S.p.A.
    Inventors: Pietro ALLEGRINI, Gabriele Razzetti, Vittorio Lucchini
  • Intermediates for the preparation of pramipexole
    Patent number: 8203002
    Abstract: Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: June 19, 2012
    Assignee: Dipharma S.p.A.
    Inventors: Graziano Castaldi, Alberto Bologna, Pietro Allegrini, Gabriele Razzetti, Vittorio Lucchini
  • Process for the purification of 1,4-butanediol mononitrate
    Patent number: 7947855
    Abstract: A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: May 24, 2011
    Assignee: Dipharma S.p.A.
    Inventors: Tiziano Scubla, Nevio Francescutti, Fausto Gorassini, Graziano Castaldi
  • Process for the mononitration of alkanediols
    Patent number: 7851649
    Abstract: A process for the preparation of compounds of formula HO-A-ONO2??(I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with “stabilized” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: December 14, 2010
    Assignee: Dipharma S.p.A.
    Inventors: Nevio Francescutti, Tiziano Scubla, Fausto Gorassini, Graziano Castaldi
  • INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE
    Publication number: 20100222595
    Abstract: Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.
    Type: Application
    Filed: May 10, 2010
    Publication date: September 2, 2010
    Applicant: DIPHARMA S.p.A.
    Inventors: Graziano CASTALDI, Alberto Bologna, Pietro Allegrini, Gabriele Razzetti, Vittorio Lucchini
  • FEXOFENADINE BASE POLYMORPHIC FORMS
    Publication number: 20100216838
    Abstract: The invention relates to novel crystalline forms of fexofenadine base, a process for the preparation thereof and the use thereof in therapy.
    Type: Application
    Filed: March 23, 2010
    Publication date: August 26, 2010
    Applicant: DIPHARMA S.P.A.
    Inventors: GIANPIERO VENTIMIGLIA, Pietro Allegrini, Graziano Castaldi
  • Intermediates for the preparation of pramipexole
    Patent number: 7741490
    Abstract: Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: June 22, 2010
    Assignee: Dipharma S.p.A.
    Inventors: Graziano Castaldi, Alberto Bologna, Pietro Allegrini, Gabriele Razzetti, Vittorio Lucchini
  • Process for the preparation of telmisartan
    Patent number: 7692027
    Abstract: A process for the preparation of telmisartan (I) and novel intermediates useful for its synthesis.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: April 6, 2010
    Assignee: Dipharma S.p.A.
    Inventors: Pietro Allegrini, Marcello Rasparini, Gabriele Razzetti, Alberto Bologna, Giuseppe Barreca
  • FEXOFENADINE POLYMORPHS AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20090111853
    Abstract: The invention provides novel crystalline forms of fexofenadine hydrochloride, a process for the preparation of the novel forms and of the known form A, and their use in therapy.
    Type: Application
    Filed: October 28, 2008
    Publication date: April 30, 2009
    Applicant: DIPHARMA S.P.A.
    Inventors: Graziano CASTALDI, Giuseppe BARRECA, Pietro ALLEGRINI, Gianpiero VENTIMIGLIA
  • PROCESS FOR THE PURIFICATION OF 1,4-BUTANEDIOL MONONITRATE
    Publication number: 20080293961
    Abstract: A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.
    Type: Application
    Filed: July 2, 2008
    Publication date: November 27, 2008
    Applicant: DIPHARMA S.P.A.
    Inventors: Tiziano Scubla, Nevio Francescutti, Fausto Gorassini, Graziano Castaldi
  • Process for the preparation of valsartan and intermediates thereof
    Patent number: 7439261
    Abstract: A novel process for the preparation of valsartan and novel intermediates useful in the preparation thereof.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: October 21, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Giancarlo Verardo, Paola Geatti, Graziano Castaldi, Nicoletta Toniutti, Pietro Allegrini
  • Process for the preparation of tolterodine
    Patent number: 7420091
    Abstract: A novel process for the preparation of tolterodine, i.e. (R)—N, N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine, in the racemic form, as well as intermediates useful for its preparation.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: September 2, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Gabriele Razzetti, Simone Mantegazza, Roberto Rossi, Pietro Allegrini
  • PROCESS FOR THE PREPARATION OF IMIQUIMOD AND INTERMEDIATES THEREOF
    Publication number: 20080161573
    Abstract: Novel intermediates useful for the preparation of Imiquimod and a process for the preparation of Imiquimod with the intermediates.
    Type: Application
    Filed: October 16, 2007
    Publication date: July 3, 2008
    Applicant: DIPHARMA S.P.A.
    Inventors: Lino COLOMBO, Enrico Mariotti, Pietro Allegrini, Graziano Castaldi
  • PROCESS FOR THE MONONITRATION OF ALKANEDIOLS
    Publication number: 20080146830
    Abstract: A process for the preparation of compounds of formula HO-A-ONO2 ??(I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with “stabilised” nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.
    Type: Application
    Filed: February 25, 2008
    Publication date: June 19, 2008
    Applicant: DIPHARMA S.P.A.
    Inventors: Nevio FRANCESCUTTI, Tiziano SCUBLA, Fausto GORASSINI, Graziano CASTALDI