Patents Assigned to Dispersol Technologies. LLC
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Publication number: 20220401579Abstract: Pharmaceutical formulations including an inclusion complex of an API with a cyclic oligomer, and methods of forming such pharmaceutical formulations are described.Type: ApplicationFiled: September 24, 2020Publication date: December 22, 2022Applicants: DISPERSOL TECHNOLOGIES, LLC, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Robert O. WILLIAMS, III, Urvi GALA, Dave MILLER, Angela SPANGENBERG, Daniel J. ELLENBERGER
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Publication number: 20220362264Abstract: The present disclosure relates to pharmaceutical formulations including abiraterone and a cyclic oligomer, as well as tablets including such pharmaceutical formulations, methods of forming such pharmaceutical formulations, and methods of administering such pharmaceutical formulations or tablets.Type: ApplicationFiled: March 17, 2020Publication date: November 17, 2022Applicants: DISPERSOL TECHNOLOGIES, LLC., BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Dave MILLER, Urvi GALA, Robert O. WILLIAMS, III, Angela SPANGENBERG
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Patent number: 11439650Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.Type: GrantFiled: May 5, 2020Date of Patent: September 13, 2022Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, DISPERSOL TECHNOLOGIES, LLCInventors: Chris Brough, James W. McGinity, Dave A. Miller, James C. DiNunzio, Robert O. Williams, III
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Publication number: 20210128536Abstract: The present disclosure relates to pharmaceutical formulations including a weakly basic drug and an ionic polymer in an amorphous solid dispersion, as well as methods of forming such pharmaceutical formulations, and methods of administering such pharmaceutical formulations.Type: ApplicationFiled: October 8, 2020Publication date: May 6, 2021Applicants: DISPERSOL TECHNOLOGIES, LLC, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Robert O. WILLIAMS, III, Scott V. JERMAIN, Daniel Alan DAVIS, Dave A. MILLER
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Publication number: 20200261473Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can he further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.Type: ApplicationFiled: May 5, 2020Publication date: August 20, 2020Applicants: BOARD OF REGENTS, THE UNIVERISTY OF TEXAS SYSTEM, DISPERSOL TECHNOLOGIES, LLCInventors: Chris BROUGH, James W. MCGINITY, Dave A. MILLER, James C. DINUNZIO, Robert O. WILLIAMS, III
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Patent number: 10668085Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.Type: GrantFiled: June 19, 2018Date of Patent: June 2, 2020Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, DISPERSOL TECHNOLOGIES, LLCInventors: Chris Brough, James W. McGinity, Dave A. Miller, James C. DiNunzio, Robert O. Williams, III
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Publication number: 20200009060Abstract: The disclosure provides for improved pharmaceutical compositions containing an active pharmaceutical ingredient and a non-polymeric lubricant and methods of manufacturing the same. In particular, the compositions are prepared using thermal processing or solvent sprying and provide improved properties as well as more efficient methods of manufacture.Type: ApplicationFiled: May 8, 2017Publication date: January 9, 2020Applicant: DISPERSOL TECHNOLOGIES, LLCInventors: Dave A. MILLER, Daniel J. ELLENBERGER, Sandra U. SCHILLING
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Publication number: 20190167643Abstract: The disclosure provides for improved pharmaceutical compositions containing deferasirox (DFX) and methods of manufacturing the same. In particular, the compositions are prepared using thermokinetic compounding and provide improved properties as well as more efficient methods of manufacture.Type: ApplicationFiled: February 6, 2019Publication date: June 6, 2019Applicant: DISPERSOL TECHNOLOGIES, LLCInventors: Dave A. MILLER, Justin M. KEEN, Sandra U. KUCERA
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Publication number: 20190142756Abstract: The disclosure provides for improved pharmaceutical compositions containing an active pharmaceutical ingredient and a non-polymeric lubricant and methods of manufacturing the same. In particular, the compositions are prepared using thermal processing or solvent spraying and provide improved properties as well as more efficient methods of manufacture.Type: ApplicationFiled: November 9, 2018Publication date: May 16, 2019Applicant: DISPERSOL TECHNOLOGIES, LLCInventors: Dave A. MILLER, Daniel J. ELLENBERGER, Sandra U. SCHILLING
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Patent number: 10265301Abstract: The disclosure provides for improved pharmaceutical compositions containing deferasirox (DFX) and methods of manufacturing the same. In particular, the compositions are prepared using thermokinetic compounding and provide improved properties as well as more efficient methods of manufacture.Type: GrantFiled: June 17, 2016Date of Patent: April 23, 2019Assignee: DISPERSOL TECHNOLOGIES, LLCInventors: Dave A. Miller, Justin M. Keen, Sandra U. Kucera
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Patent number: 10258608Abstract: The disclosure provides for improved pharmaceutical compositions containing deferasirox (DFX) and methods of manufacturing the same. In particular, the compositions are prepared using thermokinetic compounding and provide improved properties as well as more efficient methods of manufacture.Type: GrantFiled: June 28, 2017Date of Patent: April 16, 2019Assignee: DISPERSOL TECHNOLOGIES, LLCInventors: Dave A. Miller, Justin M. Keen, Sandra U. Kucera
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Publication number: 20190091339Abstract: The present disclosure relates to pharmaceutical formulations including abiraterone and a cyclic oligomer, as well as tablets including such pharmaceutical formulations, methods of forming such pharmaceutical formulations, and methods of administering such pharmaceutical formulations or tablets.Type: ApplicationFiled: September 20, 2018Publication date: March 28, 2019Applicant: DISPERSOL TECHNOLOGIES, LLCInventors: Dave Miller, Urvi Gala
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Publication number: 20180360850Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.Type: ApplicationFiled: June 19, 2018Publication date: December 20, 2018Applicants: BOARD OF REGENTS, THE UNIVERISTY OF TEXAS SYSTEM, DISPERSOL TECHNOLOGIES, LLCInventors: Chris BROUGH, James W. MCGINITY, Dave A. MILLER, James C. DINUNZIO, Robert O. WILLIAMS, III
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Patent number: 10022385Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.Type: GrantFiled: May 13, 2016Date of Patent: July 17, 2018Assignees: Board of Regents, The University of Texas System, DisperSol Technologies, LLCInventors: Chris Brough, James W. McGinity, Dave A. Miller, James C. Dinunzio, Robert O. Williams, III
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Publication number: 20170333404Abstract: The disclosure provides for improved pharmaceutical compositions containing vemurafenib and methods of manufacturing the same. In particular, the compositions are prepared using thermokinetic compounding and provide improved properties as well as more efficient methods of manufacture.Type: ApplicationFiled: November 3, 2015Publication date: November 23, 2017Applicant: DISPERSOL TECHNOLOGIES, LLCInventors: Dave Alan MILLER, Justin Martin KEEN, Chris BROUGH, Sandra U. KUCERA, Daniel J. ELLENBERGER
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Patent number: 9821283Abstract: The present disclosure provides for a first embodiment, where, a first, lower shaft speed mixing of the component combination takes place in a thermokinetic mixer, where monitoring of the batch by temperature rate increase determination results in a determination that a substantial portion of desired thermokinetic mixing has occurred, whereafter a different shaft speed is used to complete the desired thermokinetic mixing of the component combination.Type: GrantFiled: September 24, 2014Date of Patent: November 21, 2017Assignee: DISPERSOL TECHNOLOGIES, LLCInventor: Chris Brough
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Publication number: 20170296514Abstract: The disclosure provides for improved pharmaceutical compositions containing deferasirox (DFX) and methods of manufacturing the same. In particular, the compositions are prepared using thermokinetic compounding and provide improved properties as well as more efficient methods of manufacture.Type: ApplicationFiled: June 28, 2017Publication date: October 19, 2017Applicant: DISPERSOL TECHNOLOGIES, LLCInventors: Dave A. MILLER, Justin M. KEEN, Sandra U. KUCERA
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Publication number: 20170027911Abstract: The disclosure provides for improved pharmaceutical compositions containing deferasirox (DFX) and methods of manufacturing the same. In particular, the compositions are prepared using thermokinetic compounding and provide improved properties as well as more efficient methods of manufacture.Type: ApplicationFiled: June 17, 2016Publication date: February 2, 2017Applicant: Dispersol Technologies, LLCInventors: Dave A. MILLER, Justin M. KEEN, Sandra U. KUCERA
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Patent number: 9545361Abstract: The present disclosure is directed to compositions and methods for making a pharmaceutical composition by thermokinetic compounding, wherein the compositions include one or more thermolabile components, for example one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients. The methods comprise thermokinetic processing of the thermolabile components into a composite by blending certain thermolabile components in a thermokinetic mixer using multiple speeds during a single, rotationally continuous operation. The composite can be further processed into pharmaceutical compositions by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.Type: GrantFiled: July 25, 2011Date of Patent: January 17, 2017Assignee: DISPERSOL TECHNOLOGIES, LLCInventor: Chris Brough
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Publication number: 20160250230Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.Type: ApplicationFiled: May 13, 2016Publication date: September 1, 2016Applicants: BOARD OF REGENTS, THE UNIVERISTY OF TEXAS SYSTEM, DISPERSOL TECHNOLOGIES, LLCInventors: Chris BROUGH, James W. MCGINITY, Dave A. MILLER, James C. DINUNZIO, Robert O. WILLIAMS, III