Patents Assigned to Disphar International B.V.
-
Publication number: 20170000727Abstract: The invention relates to a pharmaceutical dry enema product. Said product comprises mesalazine dry granules suitable for reconstitution into enema. The pharmaceutical product preferably is supplied in a package together with an enema bottle with one-way valve. The product can be easily dispersed and after reconstitution it has required viscosity to ensure uniform suspension of the drug and better retention in inflamed mucosa and it can be applied without loss or spillage of the pharmaceutical active ingredient.Type: ApplicationFiled: December 18, 2014Publication date: January 5, 2017Applicant: DISPHAR INTERNATIONAL B.V.Inventors: José Luis VELADA, Hiteshkumar Anilkant DOSHI, Shruti Ashok HAZARE
-
Publication number: 20130183434Abstract: The invention provides a method for preparing a mesalazine enteric coated tablet comprising: (i) granulating a composition comprising mesalazine, a pharmaceutically acceptable salt, or ester thereof, into mesalazine granulates; (ii) tabletting a core composition comprising the mesalazine granulates obtained in (i) to obtain a tablet core; (iii) coating the tablet core obtained in (ii) with at least an intermediate layer and an enteric coating; where the tablet core hardness is controlled to be comprised between 80 N and 105 N and the intermediate layer represents less than 2% by weight of the tablet.Type: ApplicationFiled: September 1, 2011Publication date: July 18, 2013Applicant: DISPHAR INTERNATIONAL B.V.Inventor: Hendrik Cornelis De Fluiter
-
Patent number: 8206688Abstract: The present invention relates to a novel foam-forming composition suitable for rectal administration of locally-acting pharmaceutically active ingredients, and the product adapted to administer said foam-forming composition. Also, the present invention relates to a method for its preparation. According to the present invention a foam-forming composition is provided which exhibits a high expansion ratio and at the same time conferring optimal appearance of the formed foam to allow sufficient contact time of the active to the target site in the intestine in order to obtain optimal local effect. The composition according to the present inventions provides superior properties for the treatment of rectal diseases.Type: GrantFiled: January 12, 2007Date of Patent: June 26, 2012Assignee: Disphar International B.V.Inventors: Francois Jean-Louis Jerome Boutignon, Jean-Marc Aiache, Thomas Jean Henri Barres, Florian Tapissier
-
Publication number: 20100166672Abstract: The present invention relates to a novel foam-forming composition suitable for rectal administration of locally-acting pharmaceutically active ingredients, and the product adapted to administer said foam-forming composition. Also, the present invention relates to a method for its preparation. According to the present invention a foam-forming composition is provided which exhibits a high expansion ratio and at the same time conferring optimal appearance of the formed foam to allow sufficient contact time of the active to the target site in the intestine in order to obtain optimal local effect. The composition according to the present inventions provides superior properties for the treatment of rectal diseases.Type: ApplicationFiled: January 12, 2007Publication date: July 1, 2010Applicant: Disphar International B.V.Inventors: Francois Jean-Louis Jerome Boutignon, Jean-Marc Aiache, Thomas Jean Henri Barres, Florian Tapissier
-
Patent number: 6962717Abstract: A pharmaceutical composition for slow release of active ingredient in the gastrointestinal tract, comprising a plurality of active ingredient-containing particles coated with a material insoluble in gastric and intestinal juices, where the particles have as core a homogeneous mixture comprising an active pharmaceutical ingredient and a polymer insoluble in gastric and intestinal juices, with an average internal pore diameter not exceeding 35 ?m, makes efficient and pH-independent delaying of release possible even with comparatively small amounts of polymer. It is additionally distinguished by a long shelf life and is particularly suitable also for nonspherical particles.Type: GrantFiled: January 29, 1999Date of Patent: November 8, 2005Assignee: Disphar International B.V.Inventors: Gerald Huber, Peter Gruber