Abstract: This present invention is a novel method and wearable device for stimulating positive DNA gene expression and mitigating negative DNA gene expression in order to improve health and wellness. The invention's unique characteristics include the application of multiple modalities, their unique configuration for safe, low-power application, the wearable device's unique arrangement in a flat, flexible configuration for elastic contouring with comfort required for an extended period of wearing, and the ability to optimize and personalize the parameters and mixing among such modalities. The invention further combines biometric feedback data with Artificial Intelligence analytic capabilities, to facilitate the identification and characterization of DNA resonant frequencies, and associated “stimulus-response” modeling associated with such biological interactions.