Patents Assigned to Dr. Madaus & Co.
  • Salt of the silymarin group with aminopolyhydroxy alcohols
    Patent number: 3994925
    Abstract: Salts of polyhydroxyphenylchromanones, e.g., silymarin or one or more members of the silymarin group, are reacted with a monoaminopolyhydroxy alcohol of the formula ##EQU1## wherein X IS AN INTEGER FROM 3 TO 5; ANDR.sub.1 and R.sub.2 are hydrogen, lower alkyl or hydroxyalkylTo give chemotherapeutic salt compounds which are water soluble while retaining a high degree of medical effectiveness. The salt compounds can be administered to mammals to antagonize or mitigate liver damage and inflammation.
    Type: Grant
    Filed: January 21, 1974
    Date of Patent: November 30, 1976
    Assignee: Dr. Madaus & Co.
    Inventors: Rolf Hermann Heinrich Madaus, Gunter Halbach, Wilfried Trost