Abstract: The invention relates to a method for improving bioavailability of pharmaceutical substances and for allowing the pharmaceutical substances to permeate the blood-brain barrier, the pharmaceutical substances having at least one or more amidine, guanidine, N-hydroxyamidine (amidoxime) or N-hydroxyguanidine functions. The invention also relates to medicaments containing the correspondingly modified pharmaceutical substances.
Type:
Grant
Filed:
July 30, 2010
Date of Patent:
February 25, 2014
Assignee:
Dritte Patentportfolio Beteiligungsgesellschaft mgH & Co. KG
Inventors:
Bernd Clement, Christiane Wolter-Reeh, Helen Schenk