Patents Assigned to DUKE UNIERSITY
  • Mosaic clade M human immunodeficiency virus type 1 (HIV-1) gag immunogens
    Patent number: 9044445
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine containing nucleic acids encoding HIV-1 gag mosaic proteins, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: June 2, 2015
    Assignees: LOS ALAMOS NATIONAL SECURITY, LLC, BETH ISRAEL DEACONESS MEDICAL CENTER, DUKE UNIERSITY, THE UAB RESEARCH FOUNDATION
    Inventors: Bette T. Korber, William Fischer, Norman Letvin, Hua-Xin Liao, Barton F. Haynes, Beatrice H. Hahn